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    Benzothiophene alkanol piperazine derivatives and their use as antidepressant
    2.
    发明授权
    Benzothiophene alkanol piperazine derivatives and their use as antidepressant 失效
    苯并噻吩烷醇哌嗪衍生物及其用作抗抑郁药

    公开(公告)号：US08680097B2

    公开(公告)日：2014-03-25

    申请号：US13001998

    申请日：2009-06-30

    Applicant: Jianqi Li ,  Kai Gao ,  Na Lv

    Inventor： Jianqi Li ,  Kai Gao ,  Na Lv

    IPC: A61K31/496 ,  A61K31/5377 ,  C07D333/58 ,  C07D409/12 ,  C07D413/12

    CPC classification number: C07D409/06 ,  C07D409/14

    Abstract: The invention discloses benzothiophene alkanol piperazine derivatives and their use as antidepressants. The invention discloses the said benzothiophene alkanol piperazine derivative having triple inhibition effect on the reuptake of 5-HT, NA and DA. Compared with clinical used antidepressants so far having single target, e.g. desipramine and fluoxetine, and clinical used antidepressants so far having double targets, e.g venlafaxine and duloxetine, the said benzothiophene alkanol piperazine derivatives of the present invention may have a broader indication range and less toxic and side effects to nervous system. The benzothiophene alkanol piperazine derivatives are the compounds with the following formula or their pharmaceutically acceptable salts, wherein Ar1, R1-R4, X, Y, m and n have the same definition as defined in claim 1.

    Abstract translation: 本发明公开了苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁药的用途。 本发明公开了对5-HT，NA和DA的再摄取具有三重抑制作用的所述苯并噻吩烷醇哌嗪衍生物。 与迄今为止具有单一目标的临床使用的抗抑郁药相比， 本发明的所述苯并噻吩烷醇哌嗪衍生物可能具有更广泛的适应范围和对神经系统的毒副作用较小的临床用途的抗抑郁药，目前为止具有双重目标，例如文拉法辛和度洛西汀。 苯并噻吩烷醇哌嗪衍生物是具有下式的化合物或其药学上可接受的盐，其中Ar1，R1-R4，X，Y，m和n具有与权利要求1中所定义的相同的定义。

    Baby bassinet
    3.
    外观设计
    Baby bassinet 有权

    公开(公告)号：USD1027481S1

    公开(公告)日：2024-05-21

    申请号：US29912332

    申请日：2023-09-18

    Applicant: Kai Gao

    Designer： Kai Gao

    Abstract: FIG. 1 is a top, front, left side perspective view of a baby bassinet showing my new design;
    FIG. 2 is a bottom, back, right side perspective view thereof;
    FIG. 3 is a front view thereof;
    FIG. 4 is a back view thereof;
    FIG. 5 is a left view thereof;
    FIG. 6 is a right view thereof;
    FIG. 7 is a top plan view thereof;
    FIG. 8 is bottom plan view thereof;
    FIG. 9 is an enlarged view of detail 9 in FIG. 1;
    FIG. 10 is an enlarged view of detail 10 in FIG. 1; and,
    FIG. 11 is an enlarged view of detail 11 in FIG. 1.
    The broken lines depict portions of the baby bassinet and form no part of the claimed design.

    BENZOTHIOPHENE ALKANOL PIPERAZINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSANT
    6.
    发明申请
    BENZOTHIOPHENE ALKANOL PIPERAZINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSANT 失效
    苯并噻唑烷醇衍生物及其用作抗生素

    公开(公告)号：US20110118263A1

    公开(公告)日：2011-05-19

    申请号：US13001998

    申请日：2009-06-30

    Applicant: Jianqi Li ,  Kai Gao ,  Na Lv

    Inventor： Jianqi Li ,  Kai Gao ,  Na Lv

    IPC: A61K31/5377 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  A61K31/497 ,  A61P25/24

    CPC classification number: C07D409/06 ,  C07D409/14

    Abstract: The invention discloses benzothiophene alkanol piperazine derivatives and their use as antidepressants. The invention discloses the said benzothiophene alkanol piperazine derivative having triple inhibition effect on the reuptake of 5-HT, NA and DA. Compared with clinical used antidepressants so far having single target, e.g. desipramine and fluoxetine, and clinical used antidepressants so far having double targets, e.g venlafaxine and duloxetine, the said benzothiophene alkanol piperazine derivatives of the present invention may have a broader indication range and less toxic and side effects to nervous system. The benzothiophene alkanol piperazine derivatives are the compounds with the following formula or their pharmaceutically acceptable salts, wherein Ar1, R1-R4, X, Y, m and n have the same definition as defined in claim 1.

    Abstract translation: 本发明公开了苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁药的用途。 本发明公开了对5-HT，NA和DA的再摄取具有三重抑制作用的所述苯并噻吩烷醇哌嗪衍生物。 与迄今为止具有单一目标的临床使用的抗抑郁药相比， 本发明的所述苯并噻吩烷醇哌嗪衍生物可能具有更广泛的适应范围和对神经系统的毒副作用较小的临床用途的抗抑郁药，目前为止具有双重目标，例如文拉法辛和度洛西汀。 苯并噻吩烷醇哌嗪衍生物是具有下式的化合物或其药学上可接受的盐，其中Ar1，R1-R4，X，Y，m和n具有与权利要求1中所定义的相同的定义。

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