公开(公告)号：US20240285791A1

公开(公告)日：2024-08-29

申请号：US18024801

申请日：2021-09-02

申请人： DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FUNDATION

发明人： Moon-Chang BAEK ,  Kyung Moo YEA ,  Hanchae CHO

IPC分类号： A61K47/69 ,  A61K35/17 ,  A61K38/20 ,  A61P35/00

CPC分类号： A61K47/6901 ,  A61K35/17 ,  A61K38/2013 ,  A61P35/00

摘要： The present invention relates to an extracellular vesicle expressing a cytokine and an antibody, a method for producing same, and a use thereof. The present invention provides a method for producing an immune cell expressing both a cytokine and an antibody on membrane surface by transforming them with a first vector encoding a cytokine and a second vector encoding an antibody, and producing their extracellular vesicle expressing both a cytokine and an antibody on the surface. The present invention provides the extracellular vesicle which induces a desired cytokine response in cells that can be targeted with a specific antibody and is safe for the human body while exhibiting excellent anticancer effects. The present invention provides a new cancer treatment means that deliver drugs or physiologically active substances to specific cancer cells by loading a drug or physiologically active substance that exhibits a therapeutic effect on cancer in the extracellular vesicle.