- 专利标题: EXTRACELLULAR VESICLE EXPRESSING CYTOKINE AND ANTIBODY, METHOD FOR PRODUCING SAME, AND USE THEREOF
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申请号: US18024801申请日: 2021-09-02
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公开(公告)号: US20240285791A1公开(公告)日: 2024-08-29
- 发明人: Moon-Chang BAEK , Kyung Moo YEA , Hanchae CHO
- 申请人: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY , KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FUNDATION
- 申请人地址: KR Daegu
- 专利权人: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY,KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FUNDATION
- 当前专利权人: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY,KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FUNDATION
- 当前专利权人地址: KR Daegu
- 优先权: KR 20200112773 2020.09.04 KR 20210114652 2021.08.30
- 国际申请: PCT/KR2021/011853 2021.09.02
- 进入国家日期: 2023-03-06
- 主分类号: A61K47/69
- IPC分类号: A61K47/69 ; A61K35/17 ; A61K38/20 ; A61P35/00
摘要:
The present invention relates to an extracellular vesicle expressing a cytokine and an antibody, a method for producing same, and a use thereof. The present invention provides a method for producing an immune cell expressing both a cytokine and an antibody on membrane surface by transforming them with a first vector encoding a cytokine and a second vector encoding an antibody, and producing their extracellular vesicle expressing both a cytokine and an antibody on the surface. The present invention provides the extracellular vesicle which induces a desired cytokine response in cells that can be targeted with a specific antibody and is safe for the human body while exhibiting excellent anticancer effects. The present invention provides a new cancer treatment means that deliver drugs or physiologically active substances to specific cancer cells by loading a drug or physiologically active substance that exhibits a therapeutic effect on cancer in the extracellular vesicle.
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