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公开(公告)号：US20240261249A1
公开(公告)日：2024-08-08
申请号：US18435962
申请日：2024-02-07
Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION , KOSIN UNIVERSITY INDUSTRY-ACADEMY COOPERATION
Inventor： Hwayoung YUN , Jee-Yeong JEONG , Jinsook KWAK , Min Jung KIM , Soyeong KIM
IPC: A61K31/277 , A61K31/145 , A61P35/00 , C07C255/58 , C07C317/22
CPC classification number: A61K31/277 , A61K31/145 , A61P35/00 , C07C255/58 , C07C317/22 , C07C2601/04 , C07C2601/14
Abstract: The present invention relates to a novel squaramide derivative and a use thereof and provides a novel derivative through the strategy of replacing a compound having a urea core with the bioisolate squaramide, whereby the derivative exhibits an anticancer activity through eIF2α phosphorylation efficacy, wherein squaramide has a characteristic structure retaining a double bond linked to the carbonyl groups and the squaramide structure can be prepared by mediating a precursor bearing an amine group to the squarate ring, which is a squaric ring, through a conjugate addition reaction.
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公开(公告)号：US20220087520A1
公开(公告)日：2022-03-24
申请号：US17481093
申请日：2021-09-21
Applicant: Pukyong National University Industry-University Cooperation Foundation , KOSIN UNIVERSITY INDUSTRY-ACADEMY COOPERATION
Inventor： Yeh-Chan AHN , Daa Young KWON , Yi Keun KIM , Chul Ho OAK , Hang Goo YUN , Sung Won KIM
Abstract: Disclosed is a mobile colposcopy device for early diagnosis of cervical cancer, which includes an insertion unit which is inserted into the vagina of a woman, has a penetrating hole formed in one end coming into contact with the uterus, and is provided with a capturing path communicating with the penetrating hole, a capturing unit which is provided in the insertion unit so as to capture the cervix through the capturing path, and a lighting unit which is provided on the capturing path of the insertion unit and irradiates a lighting to the cervix through the penetrating hole. According to the present disclosure, the mobile colposcopy device for early diagnosis of cervical cancer can be simply and easily used so as to perform cervical cancer screening using a mobile colposcopy without environmental constraints including hospitals and allows women to early diagnose cervical cancer.
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公开(公告)号：US11771315B2
公开(公告)日：2023-10-03
申请号：US17481093
申请日：2021-09-21
Applicant: Pukyong National University Industry—University Cooperation Foundation , KOSIN UNIVERSITY INDUSTRY—ACADEMY COOPERATION
Inventor： Yeh-Chan Ahn , Daa Young Kwon , Yi Keun Kim , Chul Ho Oak , Hang Goo Yun , Sung Won Kim
Abstract: Disclosed is a mobile colposcopy device for early diagnosis of cervical cancer, which includes an insertion unit which is inserted into the vagina of a woman, has a penetrating hole formed in one end coming into contact with the uterus, and is provided with a capturing path communicating with the penetrating hole, a capturing unit which is provided in the insertion unit so as to capture the cervix through the capturing path, and a lighting unit which is provided on the capturing path of the insertion unit and irradiates a lighting to the cervix through the penetrating hole. According to the present disclosure, the mobile colposcopy device for early diagnosis of cervical cancer can be simply and easily used so as to perform cervical cancer screening using a mobile colposcopy without environmental constraints including hospitals and allows women to early diagnose cervical cancer.
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公开(公告)号：US20240286994A1
公开(公告)日：2024-08-29
申请号：US18565530
申请日：2022-05-31
Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION , KOSIN UNIVERSITY INDUSTRY-ACADEMY COOPERATION
Inventor： Hwayoung YUN , Jee-Yeong JEONG , Jinsook KWAK , Min Jung KIM , Soyeong KIM
IPC: C07C255/28 , A61K31/136 , A61K31/18 , A61P35/00 , C07C255/60 , C07C311/41 , C07C317/32
CPC classification number: C07C255/28 , A61K31/136 , A61K31/18 , A61P35/00 , C07C255/60 , C07C311/41 , C07C317/32 , C07C2601/04
Abstract: The present invention relates to a novel squaramide derivative and a use thereof and provides a novel derivative through the strategy of replacing a compound having a urea core with the bioisolate squaramide, whereby the derivative exhibits an anticancer activity through eIF2α phosphorylation efficacy, wherein squaramide has a characteristic structure retaining a double bond linked to the carbonyl groups and the squaramide structure can be prepared by mediating a precursor bearing an amine group to the squarate ring, which is a squaric ring, through a conjugate addition reaction.
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