公开(公告)号：US09170028B1

公开(公告)日：2015-10-27

申请号：US13267767

申请日：2011-10-06

申请人： Neil Reginald Beer ,  William J. Benett ,  James M. Frank ,  Joshua R. Deotte ,  Christopher Spadaccini

发明人： Neil Reginald Beer ,  William J. Benett ,  James M. Frank ,  Joshua R. Deotte ,  Christopher Spadaccini

IPC分类号： F24H1/00 ,  F24H1/10 ,  H05B3/78

CPC分类号： F24H1/00 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12M29/00 ,  C12M41/12 ,  C12M41/18 ,  C12M41/48 ,  F24H1/10

摘要： The rapid thermal cycling of a material is targeted. A microfluidic heat exchanger with an internal porous medium is coupled to tanks containing cold fluid and hot fluid. Fluid flows alternately from the cold tank and the hot tank into the porous medium, cooling and heating samples contained in the microfluidic heat exchanger's sample wells. A valve may be coupled to the tanks and a pump, and switching the position of the valve may switch the source and direction of fluid flowing through the porous medium. A controller may control the switching of valve positions based on the temperature of the samples and determined temperature thresholds. A sample tray for containing samples to be thermally cycled may be used in conjunction with the thermal cycling system. A surface or internal electrical heater may aid in heating the samples, or may replace the necessity for the hot tank.

摘要翻译： 材料的快速热循环是目标。 具有内部多孔介质的微流体热交换器耦合到容纳冷流体和热流体的罐。 流体从冷箱和热罐交替地流入多孔介质，冷却和加热微流体换热器样品孔中包含的样品。 阀可以联接到罐和泵，并且切换阀的位置可以切换流过多孔介质的流体的源和方向。 控制器可以基于样品的温度和确定的温度阈值来控制阀位置的切换。 用于包含热循环样品的样品盘可以与热循环系统一起使用。 表面或内部电加热器可能有助于加热样品，也可能取代热水箱的必要性。