公开(公告)号：US10202342B2

公开(公告)日：2019-02-12

申请号：US12975655

申请日：2010-12-22

Applicant: Joseph P. Y. Kao ,  Scott R. Burks ,  Gerald R. Rosen

Inventor： Joseph P. Y. Kao ,  Scott R. Burks ,  Gerald R. Rosen

IPC: C07D207/46 ,  A61K49/00 ,  A61K49/10 ,  A61K49/18 ,  A61K49/20 ,  C07D211/94 ,  C07D403/06 ,  A61B5/055 ,  G01N33/542 ,  G01N33/543 ,  G01N33/574 ,  G01R33/60 ,  A61B5/00

Abstract: The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue.

公开(公告)号：US6043065A

公开(公告)日：2000-03-28

申请号：US997239

申请日：1997-12-23

Applicant: Joseph P. Y. Kao ,  Francis M. Rossi ,  Paul F. Keitz

Inventor： Joseph P. Y. Kao ,  Francis M. Rossi ,  Paul F. Keitz

IPC: C07C205/56 ,  C12N13/00 ,  C07C41/00 ,  C07C69/96

CPC classification number: C12N13/00 ,  C07C205/56

Abstract: Derivatives of o-nitromandelyoxycarbonyl (Nmoc) which are capable of releasing 2,5,-di(tert-butyl)hydroquinone (DBHQ) upon irradiation with ultraviolet (UV) light, are disclosed, as well as, a method for producing DBHQ employing the same so as to allow rapid, reversible transient inhibition of sarcoplasmic/endoplasmic reticulum Ca.sup.2+ ATPases.

Abstract translation: 公开了在用紫外（UV）光照射时能够释放2,5'-二（叔丁基）氢醌（DBHQ）的邻硝基二烯丙氧基羰基（Nmoc）的衍生物，以及用于制备DBHQ的方法，其采用 相同的，以允许快速，可逆的瞬时抑制肌质/内质网Ca2 + ATP酶。

公开(公告)号：US5670664A

公开(公告)日：1997-09-23

申请号：US525173

申请日：1995-09-08

Applicant: Joseph P. Y. Kao ,  Paul F. Keitz

Inventor： Joseph P. Y. Kao ,  Paul F. Keitz

IPC: C07D317/72

CPC classification number: C07D317/72

Abstract: The present invention relates to acetal derivatives of bicyclo�2.2.1!hepta-2,5-diene-7-one (norbornadienone) which are capable of releasing carbon monoxide upon irradiation with ultraviolet light, and a method for producing carbon monoxide employing the same.

Abstract translation: 本发明涉及在用紫外线照射时能够释放一氧化碳的双环[2.2.1]七-2,5-二烯-7-酮（降冰片二烯酮）的缩醛衍生物，以及使用 相同。

公开(公告)号：US4222839A

公开(公告)日：1980-09-16

申请号：US944427

申请日：1978-09-21

Applicant: Willis R. Goodner ,  Joseph P. Y. Kao

Inventor： Willis R. Goodner ,  Joseph P. Y. Kao

IPC: C30B33/00 ,  C23F1/00 ,  B01K1/00

CPC classification number: C30B33/00

Abstract: A holder and method for controlling and uniformly maintaining the temperature of work pieces when the work pieces are acted upon by a plasma in a plasma reactor apparatus. Support means which hold the work pieces so as to expose them to the reactive plasma also position metallic plate members which are capable of being heated to an elevated temperature by the plasma when in electrical contact with an electrode of the plasma reactor apparatus. The metallic plate members are all electrically shorted together, but are insulated from the support means. A temperature sensitive switch connects the metallic plate members to an electrode of the plasma apparatus. Work pieces to be acted upon by the plasma are placed in proximity to the metal plate members. In the presence of a plasma and when shorted to the apparatus electrode, the metallic plate members are rapidly heated and heat is conducted to the work pieces to heat them uniformly. The temperature of the work pieces is controlled by selectively opening and closing the temperature sensitive switch and thereby selectively shorting the metal members to the apparatus electrode. Little heating occurs when the switch is open and the members are isolated from the electrode.

Abstract translation: 一种用于在等离子体反应器装置中通过等离子体作用工件时控制和均匀地保持工件的温度的保持器和方法。 保持工件以便将它们暴露于反应性等离子体的支撑装置还定位当与等离子体反应器装置的电极电接触时能够被等离子体加热到升高的温度的金属板构件。 金属板构件全部电短路在一起，但与支撑装置绝缘。 温度敏感开关将金属板构件连接到等离子体装置的电极。 待等离子体作用的工件被放置在金属板构件附近。 在等离子体的存在下，当与设备电极短路时，金属板构件被快速加热，并且热量被传导到工件以均匀地加热它们。 通过选择性地打开和关闭温度敏感开关来控制工件的温度，从而将金属构件选择性地短路到设备电极。 当开关打开并且构件与电极隔离时，几乎不发生加热。