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公开(公告)号：US07902358B2
公开(公告)日：2011-03-08
申请号：US11647091
申请日：2006-12-28
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , A61K31/506 , A61P1/00 , A61P1/06
CPC分类号： C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要翻译： 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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公开(公告)号：US20080287445A1
公开(公告)日：2008-11-20
申请号：US11646957
申请日：2006-12-28
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC分类号： A61K31/505 , A61K31/435 , A61P1/00 , A61K31/53
CPC分类号： A61K31/506 , A61K31/53
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.
摘要翻译： 本发明涉及某些新的式（I）化合物：以及用于治疗促动蛋白原2或原激素2受体介导的病症的方法。
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公开(公告)号：US20080269225A1
公开(公告)日：2008-10-30
申请号：US11647091
申请日：2006-12-28
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC分类号： A61K31/53 , C07D405/12 , A61P29/00 , A61P1/00
CPC分类号： C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要翻译： 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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公开(公告)号：US08471005B2
公开(公告)日：2013-06-25
申请号：US13160890
申请日：2011-06-15
申请人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号： C07D487/04 , C07D403/12 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I化合物或其盐形式，其中Q 1，Q 2，Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US20120028997A1
公开(公告)日：2012-02-02
申请号：US12970461
申请日：2010-12-16
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC分类号： A61K31/515 , C07D401/06 , C07D403/12 , A61P1/12 , A61P1/00 , A61P35/00 , A61P29/00 , C07D401/12 , A61K31/513
CPC分类号： C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
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公开(公告)号：US20120028919A1
公开(公告)日：2012-02-02
申请号：US13160890
申请日：2011-06-15
申请人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人： Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号： A61K31/5377 , C07D223/16 , A61P35/00 , A61K31/53 , A61K31/695 , C07D487/04 , A61K31/55
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I化合物或其盐形式，其中Q 1，Q 2，Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性，可用于治疗增殖性疾病。
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7.发明授权Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors 有权2,4-二氨基嘧啶作为ALK和c-MET抑制剂的稠合双环衍生物公开(公告)号：US08552186B2
公开(公告)日：2013-10-08
申请号：US13413322
申请日：2012-03-06
申请人： Gulzar Ahmed , Henry J. Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce D. Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph Lisko , Rong-qiang Liu , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
发明人： Gulzar Ahmed , Henry J. Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce D. Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph Lisko , Rong-qiang Liu , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
IPC分类号： C07D403/12
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。 式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。
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公开(公告)号：US20120129862A1
公开(公告)日：2012-05-24
申请号：US13113751
申请日：2011-05-23
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
IPC分类号： A61K31/53 , C07D403/12 , C07D251/20 , A61P29/00 , C07D251/38 , A61P1/00 , A61P1/12 , A61P35/00 , C07D251/46 , C07D251/30
CPC分类号： C07D239/545 , C07D251/20 , C07D251/34 , C07D251/38 , C07D251/46 , C07D403/12
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要翻译： 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体和衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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公开(公告)号：US20090163505A1
公开(公告)日：2009-06-25
申请号：US12256891
申请日：2008-10-23
申请人： Steven J. COATS , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
发明人： Steven J. COATS , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
IPC分类号： A61K31/53 , C07D403/12 , A61P1/00 , A61P35/00
CPC分类号： C07D251/38 , C07D401/12 , C07D403/12 , C07D405/14
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要翻译： 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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公开(公告)号：US20140038968A1
公开(公告)日：2014-02-06
申请号：US13653452
申请日：2012-10-17
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
IPC分类号： C07D251/38 , C07D403/12
CPC分类号： C07D251/38 , C07D401/12 , C07D403/12 , C07D405/14
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要翻译： 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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