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公开(公告)号：US5821242A
公开(公告)日：1998-10-13
申请号：US868638
申请日：1997-06-04
申请人： Joseph Matthew Colacino , Beverly Ann Heinz , Louis Nickolaus Jungheim , Shawn Christopher Miller , Wayne Alfred Spitzer , Joseph Chiou-chung Tang , Mark Joseph Tebbe , Frantz Victor
发明人： Joseph Matthew Colacino , Beverly Ann Heinz , Louis Nickolaus Jungheim , Shawn Christopher Miller , Wayne Alfred Spitzer , Joseph Chiou-chung Tang , Mark Joseph Tebbe , Frantz Victor
IPC分类号： A61K31/415 , A61K31/4184 , A61P31/12 , C07D235/30 , C07D235/22 , C07D235/08
CPC分类号： C07D235/30
摘要： The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus and flaviviruses such as hepatitis C and bovine diarrheal virus.
摘要翻译： 本申请提供了一系列苯并咪唑化合物，其抑制微小核糖核酸病毒，例如鼻病毒，肠病毒，脊髓灰质炎病毒，A组和B组的柯萨奇病毒，回波病毒和孟戈病毒以及黄病毒如丙型肝炎和牛腹泻病毒的生长。
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公开(公告)号：US06268175B1
公开(公告)日：2001-07-31
申请号：US08987121
申请日：1997-12-08
IPC分类号： C07H2104
CPC分类号： G01N33/56944 , C07K14/3156 , C12N9/1247 , C12N15/1006 , C12N15/746 , C12Y302/01018 , G01N2333/315 , Y10S435/822
摘要： The invention provides isolated nucleic acid compounds encoding gcp of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
摘要翻译： 本发明提供编码肺炎链球菌gcp的分离的核酸化合物。 还提供了用于表达编码的蛋白质的载体和转化的宿主细胞，以及用于鉴定结合和/或抑制所述蛋白质的化合物的方法。
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公开(公告)号：US6060282A
公开(公告)日：2000-05-09
申请号：US987144
申请日：1997-12-08
IPC分类号： C07K14/315 , C12N1/21 , C12N9/12 , C12N9/24 , C12N15/10 , C12N15/31 , C12N15/74 , C12P21/04 , G01N33/569 , C12P21/06
CPC分类号： G01N33/56944 , C07K14/3156 , C12N15/1006 , C12N15/746 , C12N9/1247 , C12Y302/01018 , G01N2333/315 , Y10S435/822
摘要： The invention provides isolated nucleic acid compounds encoding dpj of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
摘要翻译： 本发明提供编码肺炎链球菌dpj的分离的核酸化合物。 还提供了用于表达编码的蛋白质的载体和转化的宿主细胞，以及用于鉴定结合和/或抑制所述蛋白质的化合物的方法。
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公开(公告)号：US6037348A
公开(公告)日：2000-03-14
申请号：US795731
申请日：1997-02-05
申请人： Joseph Matthew Colacino , Steven Duane Hatch , William Joseph Hornback , Mark Ayer Muesing , John Edwin Munroe , Kirk Alan Staschke , Joseph Chiou-Chung Tang
发明人： Joseph Matthew Colacino , Steven Duane Hatch , William Joseph Hornback , Mark Ayer Muesing , John Edwin Munroe , Kirk Alan Staschke , Joseph Chiou-Chung Tang
IPC分类号： A61K45/00 , A61K31/19 , A61K31/192 , A61K31/216 , A61K31/385 , A61K31/4409 , A61K31/4425 , A61P31/12 , A61P31/16 , C12N7/01 , A01N43/42 , A01N37/00 , A61K31/21 , A61K31/44
CPC分类号： A61K31/19 , A61K31/192 , A61K31/216 , A61K31/385 , A61K31/4409 , A61K31/4425
摘要： The present invention provides a method of inhibiting influenza and flaviviral replication based on a mechanism of action in which HA-mediated fusion or E protein mediated fusion is inhibited by a fusion inhibiting agent which binds, complexes or otherwise becomes associated with HA or E protein during the translation of the target protein and/or its vesicular transport.
摘要翻译： 本发明提供了一种基于动作机制抑制流感和黄病毒复制的方法，其中HA介导的融合或E蛋白介导的融合被融合抑制剂抑制，所述融合抑制剂与HA或E蛋白结合，复合或以其它方式变得与HA或E蛋白相关 目标蛋白质的翻译和/或其水泡运输。
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公开(公告)号：US5891874A
公开(公告)日：1999-04-06
申请号：US868760
申请日：1997-06-04
申请人： Joseph Matthew Colacino , Beverly Ann Heinz , Louis Nickolaus Jungheim , Shawn Christopher Miller , Wayne Alfred Spitzer , Joseph Chiou-chung Tang , Mark Joseph Tebbe , Frantz Victor
发明人： Joseph Matthew Colacino , Beverly Ann Heinz , Louis Nickolaus Jungheim , Shawn Christopher Miller , Wayne Alfred Spitzer , Joseph Chiou-chung Tang , Mark Joseph Tebbe , Frantz Victor
IPC分类号： A61K31/415 , C07D235/06 , C07D235/30 , C07D409/12 , A61K31/535 , A61K31/445 , C07D403/02 , C07D417/00
CPC分类号： C07D409/12 , C07D235/30
摘要： A series of benzimidazole compounds having the following general structure are provided which inhibit the growth of picornaviruses (e.g., rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus) and flaviviruses (e.g., hepatitis C and bovine diarrheal virus). ##STR1## A method for inhibiting picornaviruses and flaviviruses is also provided which includes administering to a host an effective amount of the inventive benzimidazole compounds.
摘要翻译： 提供了一系列具有以下一般结构的苯并咪唑化合物，其抑制小核糖核酸病毒（例如，鼻病毒，肠病毒，脊髓灰质炎病毒，A组和B组的柯萨奇病毒，回波病毒和Mengo病毒）和黄病毒（例如，丙型肝炎和牛 腹泻病毒）。 还提供了一种抑制微小核糖核酸病毒和黄病毒的方法，其包括向宿主施用有效量的本发明苯并咪唑化合物。
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