Biomarkers For Head And Neck Cancer And Methods Of Their Use

    公开(公告)号:US20200277678A1

    公开(公告)日:2020-09-03

    申请号:US16857767

    申请日:2020-04-24

    申请人: Shi-long LU John SONG

    发明人: Shi-long LU John SONG

    IPC分类号: C12Q1/6886 C12Q1/70

    摘要: Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell carcinoma (HNSCC). These results represent the first use of quantitative MS-PCR for the detection of mgmiRs. In addition, this panel demonstrates the ability to detect hypermethylation in the adjacent mucosa of cancer patients, suggesting its utility in early detection. This panel is also capable of detecting cancer by using saliva, blood and FNA tissue samples.

    Intervertebral disc replacement prosthesis
    4.
    发明申请
    Intervertebral disc replacement prosthesis 审中-公开
    椎间盘置换假体

    公开(公告)号:US20070233255A1

    公开(公告)日:2007-10-04

    申请号:US11714486

    申请日:2007-03-06

    IPC分类号: A61F2/44

    摘要: An intervertebral disc replacement prosthesis for placement between two adjacent vertebrae which comprises two bone cantacting members and an intermediate member with a cavity. A first bone contacting member has bone contacting surface for contacting and/or incorporating to a first vertebra and a bearing surface which substantially mates with the intermediate member. A second bone contacting member has a bone contacting surface for contacting and/or incorporating to a second vertebra, a bearing surface which substantially mates with the intermediate bearing member, and a flexible protrusion which substantially captures the intermediate bearing member and contacts and/or incorporates with the first vertebra. The flexible member may be in the form of a spring, flexible cable, or polymer.

    摘要翻译: 用于放置在两个相邻椎骨之间的椎间盘置换假体,其包括两个骨悬臂构件和具有空腔的中间构件。 第一骨接触构件具有用于接触和/或结合到与中间构件基本配合的第一椎骨和支承表面的骨接触表面。 第二骨接触构件具有用于接触和/或结合到第二椎骨的骨接触表面,基本上与中间轴承构件配合的支承表面和基本上捕获中间轴承构件并且/或并入的柔性突起 与第一脊椎。 柔性构件可以是弹簧,柔性电缆或聚合物的形式。

    Method for fabricating a field emission device having reduced
row-to-column leakage
    5.
    发明授权
    Method for fabricating a field emission device having reduced row-to-column leakage 失效
    制造具有减少的列到列泄漏的场致发射器件的方法

    公开(公告)号:US5821132A

    公开(公告)日:1998-10-13

    申请号:US912612

    申请日:1997-08-18

    CPC分类号: H01J9/025

    摘要: A method for fabricating a diamond-like carbon field emission device (300, 800) includes the steps of: (i) forming on a column conductor (330, 830) a ballast layer (364), (ii) forming on the ballast layer (364), in registration with a central well region (332, 832) of the column conductor (330, 830), a surface emitter (370, 870) made from diamond-like carbon, (iii) forming on the ballast layer (364) and surface emitter (370, 870) a field shaping layer (374), (iv) pattering the ballast layer (364) and the field shaping layer (374) to form a ballast (365) and field shaper layer (377) having opposed edges which, with the opposed edges of the column conductor (330, 830), define smooth, continuous surfaces (371, 871), (v) depositing a blanket dielectric layer (341), and (vi) forming an emission well (360, 860) above the central well region (332, 832) of the column conductor (330, 830).

    摘要翻译: 制造类金刚石碳场发射器件(300,800)的方法包括以下步骤:(i)在列导体(330,830)上形成压载层(364),(ii)在镇流器层上形成 (364)与列导体(330,830)的中心阱区域(332,832)对准,由类金刚石碳制成的表面发射器(370,870),(iii)在压载层( 364)和表面发射器(370,870),场成形层(374),(iv)图案化镇流器层(364)和场成形层(374)以形成镇流器(365)和场成形层(377) 具有相对的边缘,其中柱导体(330,830)的相对边缘限定平滑的连续表面(371,871),(v)沉积覆盖介电层(341),和(vi)形成发射阱 (360,860)在列导体(330,830)的中心阱区域(332,832)之上。

    Field emission device
    6.
    发明授权
    Field emission device 失效
    场发射装置

    公开(公告)号:US5760535A

    公开(公告)日:1998-06-02

    申请号:US740583

    申请日:1996-10-31

    IPC分类号: H01J1/304 H01J3/02 H01J1/02

    CPC分类号: H01J3/022 H01J2201/025

    摘要: A field emission device (200, 300, 400, 500) includes a supporting substrate (210, 310, 410, 510), a cathode (215, 315, 415, 515) formed thereon, a plurality of electron emitters (270, 370, 470, 570) and a plurality of gate extraction electrodes (250, 350, 450, 550) proximately disposed to the plurality of electron emitters (270, 370, 470, 570) for effecting electron emission therefrom, a major dielectric surface (248, 348, 448, 548) disposed between the plurality of gate extraction electrodes (250, 350, 450, 550), a charge dissipation layer (252, 352, 452, 552) formed on the major dielectric surface (248, 348, 448, 548), and an anode (280, 380, 480, 580) spaced from the gate extraction electrodes (250, 350, 450, 550).

    摘要翻译: 场致发射器件(200,300,400,500)包括支撑衬底(210,310,410,510),形成在其上的阴极(215,315,415,515),多个电子发射器(270,370 ,多个栅极引出电极(250,350,450,550),所述多个栅极引出电极(250,350,450,550)近似地设置在所述多个电子发射器(270,370,470,570)中,用于从其发射电子发射,主电介质表面(248 ,348,448,548),其布置在所述多个栅极引出电极(250,350,450,550)之间,形成在所述主电介质表面(248,348,448)上的电荷耗散层(252,352,452,552) ,548)以及与栅极引出电极(250,350,450,550)间隔开的阳极(280,380,480,580)。

    Single substrate, vacuum fluorescent display
    7.
    发明授权
    Single substrate, vacuum fluorescent display 失效
    单基板,真空荧光显示

    公开(公告)号:US5345141A

    公开(公告)日:1994-09-06

    申请号:US45407

    申请日:1993-03-29

    摘要: A single substrate, vacuum fluorescent display including a first layer of electrically conductive material positioned on a supporting substrate and a light emitting layer including phosphor positioned on the first layer. A second layer of electrically conductive material is supported on the substrate and electrically insulated from the first layer. An electron emitting layer of low work function material is positioned on the second layer and further positioned so that emitted electrons strike the light emitting layer. Since both the electron emitting and the light emitting layers are supported on the substrate, an encapsulating window is simple and easy to construct. Integrated drivers are optionally formed in the supporting substrate.

    摘要翻译: 单个基板,真空荧光显示器,其包括位于支撑基板上的第一导电材料层和包含位于第一层上的荧光体的发光层。 第二层导电材料被支撑在基底上并与第一层电绝缘。 低功函数材料的电子发射层位于第二层上,并进一步定位成使得发射的电子撞击发光层。 由于电子发射层和发光层都被支撑在基板上,所以封装窗口简单易于构造。 集成驱动器可选地形成在支撑基板中。

    Minimally Invasive Retractor
    8.
    发明申请
    Minimally Invasive Retractor 审中-公开
    微创牵引器

    公开(公告)号:US20140275793A1

    公开(公告)日:2014-09-18

    申请号:US14210702

    申请日:2014-03-14

    申请人: John Song

    发明人: John Song

    IPC分类号: A61B17/02

    摘要: A bone screw mounted retractor apparatus for use in minimally invasive surgery, preferably minimally invasive spine surgery, comprising a screw extension detachably attached to a bone screw, a mounting ring attached to the screw extension, a connection arm attached to the mounting dag, a retractor retaining ring attached to the connection arm, and a tubular retractor body retained by the retractor retaining ring, as well as methods of minimally invasive surgery using such an apparatus.

    摘要翻译: 一种用于微创手术,优选微创脊柱手术的骨螺钉安装的牵开器装置,包括可拆卸地附接到骨螺钉的螺钉延伸部,附接到螺钉延伸部上的安装环,连接到安装爪的连接臂,牵开器 附接到连接臂的保持环和由牵开器保持环保持的管状牵缩器主体以及使用这种装置的微创手术的方法。

    Field emission device having dielectric focusing layers
    10.
    发明授权
    Field emission device having dielectric focusing layers 失效
    具有电介质聚焦层的场致发射器件

    公开(公告)号:US06204597B1

    公开(公告)日:2001-03-20

    申请号:US09246857

    申请日:1999-02-05

    IPC分类号: H01J102

    CPC分类号: H01J3/022

    摘要: A field emission device (110, 210, 310, 410) includes an electron emitter (124), a first dielectric focusing layer (122) defining a first aperture (127), and a second dielectric focusing layer (123) defining a second aperture (133). Second dielectric focusing layer (123) is disposed on first dielectric focusing layer (122). The dielectric constant of second dielectric focusing layer (123) is less than the dielectric constant of first dielectric focusing layer (122). During the operation of field emission device (110, 210, 310), electron emitter (124) emits an electron beam (134), which is focused as it travels through first aperture (127) and then through second aperture (133).

    摘要翻译: 场发射器件(110,210,310,410)包括电子发射器(124),限定第一孔(127)的第一介电聚焦层(122)和限定第二孔径的第二介电聚焦层(123) (133)。 第二介电聚焦层(123)设置在第一介电聚焦层(122)上。 第二介电聚焦层(123)的介电常数小于第一介电聚焦层(122)的介电常数。 在场发射装置(110,210,310)的操作期间,电子发射器(124)发射电子束(134),当电子束(134)行进通过第一孔(127)然后通过第二孔(133)时,该电子束被聚焦。