摘要:
Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell carcinoma (HNSCC). These results represent the first use of quantitative MS-PCR for the detection of mgmiRs. In addition, this panel demonstrates the ability to detect hypermethylation in the adjacent mucosa of cancer patients, suggesting its utility in early detection. This panel is also capable of detecting cancer by using saliva, blood and FNA tissue samples.
摘要:
According to various aspects, exemplary embodiments are disclosed of shielding structures including one or more frequency selective surfaces, which may be used for attenuating, reflecting, and/or redirecting electromagnetic signals through open structures. Also disclosed are methods of using one or more frequency selective surfaces for attenuating, reflecting, and/or redirecting electromagnetic signals through open structures.
摘要:
An intervertebral disc replacement prosthesis for placement between two adjacent vertebrae which comprises two bone cantacting members and an intermediate member with a cavity. A first bone contacting member has bone contacting surface for contacting and/or incorporating to a first vertebra and a bearing surface which substantially mates with the intermediate member. A second bone contacting member has a bone contacting surface for contacting and/or incorporating to a second vertebra, a bearing surface which substantially mates with the intermediate bearing member, and a flexible protrusion which substantially captures the intermediate bearing member and contacts and/or incorporates with the first vertebra. The flexible member may be in the form of a spring, flexible cable, or polymer.
摘要:
A method for fabricating a diamond-like carbon field emission device (300, 800) includes the steps of: (i) forming on a column conductor (330, 830) a ballast layer (364), (ii) forming on the ballast layer (364), in registration with a central well region (332, 832) of the column conductor (330, 830), a surface emitter (370, 870) made from diamond-like carbon, (iii) forming on the ballast layer (364) and surface emitter (370, 870) a field shaping layer (374), (iv) pattering the ballast layer (364) and the field shaping layer (374) to form a ballast (365) and field shaper layer (377) having opposed edges which, with the opposed edges of the column conductor (330, 830), define smooth, continuous surfaces (371, 871), (v) depositing a blanket dielectric layer (341), and (vi) forming an emission well (360, 860) above the central well region (332, 832) of the column conductor (330, 830).
摘要:
A field emission device (200, 300, 400, 500) includes a supporting substrate (210, 310, 410, 510), a cathode (215, 315, 415, 515) formed thereon, a plurality of electron emitters (270, 370, 470, 570) and a plurality of gate extraction electrodes (250, 350, 450, 550) proximately disposed to the plurality of electron emitters (270, 370, 470, 570) for effecting electron emission therefrom, a major dielectric surface (248, 348, 448, 548) disposed between the plurality of gate extraction electrodes (250, 350, 450, 550), a charge dissipation layer (252, 352, 452, 552) formed on the major dielectric surface (248, 348, 448, 548), and an anode (280, 380, 480, 580) spaced from the gate extraction electrodes (250, 350, 450, 550).
摘要:
A single substrate, vacuum fluorescent display including a first layer of electrically conductive material positioned on a supporting substrate and a light emitting layer including phosphor positioned on the first layer. A second layer of electrically conductive material is supported on the substrate and electrically insulated from the first layer. An electron emitting layer of low work function material is positioned on the second layer and further positioned so that emitted electrons strike the light emitting layer. Since both the electron emitting and the light emitting layers are supported on the substrate, an encapsulating window is simple and easy to construct. Integrated drivers are optionally formed in the supporting substrate.
摘要:
A bone screw mounted retractor apparatus for use in minimally invasive surgery, preferably minimally invasive spine surgery, comprising a screw extension detachably attached to a bone screw, a mounting ring attached to the screw extension, a connection arm attached to the mounting dag, a retractor retaining ring attached to the connection arm, and a tubular retractor body retained by the retractor retaining ring, as well as methods of minimally invasive surgery using such an apparatus.
摘要:
An intervertebral disc prosthesis for placement between a first vertebra and a second vertebra adjacent to the first vertebra. In one embodiment, the intervertebral disc prosthesis includes a resilient member, a first support member and a second support member. The first support member and the second support member are housed into the resilient member that is arranged, in use, to be secured to the first vertebra and the second vertebra, respectively. The intervertebral disc prosthesis can generate a coupled motion in more than one possible direction responsive to a possible movement of at least one of the first vertebra and the second vertebra, among the resilient member, the first support member and the second support member.
摘要:
A field emission device (110, 210, 310, 410) includes an electron emitter (124), a first dielectric focusing layer (122) defining a first aperture (127), and a second dielectric focusing layer (123) defining a second aperture (133). Second dielectric focusing layer (123) is disposed on first dielectric focusing layer (122). The dielectric constant of second dielectric focusing layer (123) is less than the dielectric constant of first dielectric focusing layer (122). During the operation of field emission device (110, 210, 310), electron emitter (124) emits an electron beam (134), which is focused as it travels through first aperture (127) and then through second aperture (133).