COLD PLASMA TREATMENT MEDIATED MUTANT SPECIFIC T CELL IMMUNITY

    公开(公告)号:US20230313147A1

    公开(公告)日:2023-10-05

    申请号:US18207487

    申请日:2023-06-08

    IPC分类号: C12N5/09

    CPC分类号: C12N5/0693 C12N2500/02

    摘要: A method for producing cold atmospheric plasma-produced exosomes ex vivo for use in systemic treatment of cancer. The method comprises isolating patient cancerous tumor primary cells, culturing isolated patient cancerous tumor primary cells in appropriate culture media, sequencing said isolated patient cancerous tumor primary cells and identifying mutant genes, transfecting mutant genes into pots of cells, wherein the transformed cells overexpress a unique mutant protein, treating the pots of transformed cells with cold atmospheric plasma to cause apoptosis of said transformed cells, wherein apoptotic cells secrete exosomes containing oxidized mutant proteins, isolating said exosomes containing oxidized mutant proteins, and storing said exosomes. The method may further comprise injecting said exosomes into a patient to systemically treat cancer.

    SYSTEM AND METHOD FOR VOICE-CONTROL OF ELECTROSURGICAL SYSTEM

    公开(公告)号:US20220076824A1

    公开(公告)日:2022-03-10

    申请号:US17471828

    申请日:2021-09-10

    IPC分类号: G16H40/67 A61B18/12 A61B34/30

    摘要: A system and method for voice control of operating room electrical equipment. The system comprises an electrosurgical generator a controller with a memory, a graphical user interface controlled by said controller, a power module, a field programmable gate array, and a voice recognition module connected to said field programmable gate array, a data storage connected to said controller in said electrosurgical generator; and electrical operating room equipment connected to said voice recognition module, wherein said electrical operating room equipment is configured to receive and decrypt encrypted commands from said voice recognition module. The electrical operating room equipment may said electrosurgical generator or a robotic surgical system or other electrical equipment in an operating room. The connection between said electrical operating room equipment and said voice recognition module may be wireless. The connection between said data storage and said controller in said electrosurgical system also may be wireless.

    MICRO-COLD ATMOSPHERIC PLASMA DEVICE
    8.
    发明申请

    公开(公告)号:US20180271579A1

    公开(公告)日:2018-09-27

    申请号:US15936290

    申请日:2018-03-26

    IPC分类号: A61B18/04

    摘要: A micro-sized CAP (μCAP) employed to target glioblastoma tumors in the murine brain. Various plasma diagnostic techniques were applied to evaluate the physics of helium μCAP such as electron density, discharge voltage, and optical emission spectroscopy. The direct and indirect effects of μCAP on glioblastoma (U87MG-RedFluc) cancer cells in vitro were investigated and indicate that μCAP-generated short- and long-lived species and radicals [i.e. hydroxyl radical (OH), hydrogen peroxide (H2O2), nitrite (NO2-), et al] with increasing tumor cell death in a dose-dependent fashion. Translation of these findings to an in vivo setting demonstrates that intracranial μCAP is effective at preventing glioblastoma tumor growth in the mouse brain. The μCAP device can be safely used in mice, resulting in suppression of tumor growth. These initial observations establish the μCAP device as a potentially useful ablative therapy tool in the treatment of glioblastoma.

    Surgical scissors with argon plasma coagulation capability
    10.
    发明授权
    Surgical scissors with argon plasma coagulation capability 有权
    手术剪刀具有氩等离子体凝血能力

    公开(公告)号:US07549990B2

    公开(公告)日:2009-06-23

    申请号:US10959542

    申请日:2004-10-06

    申请人: Jerome Canady

    发明人: Jerome Canady

    IPC分类号: A61B18/18

    摘要: Surgical scissors having argon plasma coagulation capability are shown. The surgical scissors include in their body a channel for receiving a flexible tube having a wire within it. The flexible tubing and wire within it are connected to a generator that provides electrical energy to the wire and argon or other inert gas to the tube. The flexible tubing travels a portion of the length of the scissors and ends with a coaxial connector in the proximity of the cutting edges of the scissors. An argon plasma coagulation sleeve is placed on the cutting end of one or both sides of the scissors and is connected to the flexible tubing and wire through the coaxial connector. Each sleeve has one or more ports for discharging electrified argon gas that coagulates tissue.

    摘要翻译: 显示具有氩等离子体凝固能力的手术剪刀。 手术剪刀在其本体中包括用于接收其中具有线的柔性管的通道。 其中的柔性管和线连接到发电机,该发电机向导线提供电能,并将氩或其它惰性气体提供给管。 柔性管道沿着剪刀长度的一部分行进,并在剪刀的切割边缘附近用同轴连接器端接。 氩等离子体凝固套管放置在剪刀的一侧或两侧的切割端上,并通过同轴连接器连接到柔性管和导线。 每个套筒具有一个或多个用于排出凝结组织的带电氩气的端口。