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公开(公告)号:US5852049A
公开(公告)日:1998-12-22
申请号:US809028
申请日:1997-03-21
申请人: Michel Perez , Serge Halazy , Gareth John , Jean-Pierre Valentin , Peter Pauwels
发明人: Michel Perez , Serge Halazy , Gareth John , Jean-Pierre Valentin , Peter Pauwels
IPC分类号: C07D401/04 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4427 , A61K31/445 , A61P25/00 , A61P25/28 , A61P43/00 , C07D209/14 , C07D209/16 , C07D209/88 , C07D401/06 , C07D403/06
CPC分类号: C07D401/06 , C07D209/16 , C07D403/06
摘要: The present invention relates to new aromatic ethers derived from indole and having general formula (I) as well as to their preparation methods, pharmaceutical compositions containing them and their utilization as a medicament for the treatment of diseases linked to the dysfunction of the 5HT.sub.1 -like receptors. ##STR1##
摘要翻译: PCT No.PCT / FR95 / 01220 Sec。 371日期1997年3月21日 102(e)1997年3月21日PCT PCT 1995年9月22日PCT公布。 出版物WO96 / 09288 日期:1996年3月28日本发明涉及衍生自吲哚并具有通式(I)的新型芳香醚及其制备方法,含有它们的药物组合物及其用作治疗与功能障碍相关疾病的药物 的5HT1样受体。 (一)
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公开(公告)号:US08468796B2
公开(公告)日:2013-06-25
申请号:US12100603
申请日:2008-04-10
IPC分类号: F02K3/02
CPC分类号: F02K1/566 , F02K1/64 , F02K1/68 , F02K1/74 , Y02T50/671
摘要: A by-pass turbojet including a thrust reverser is disclosed. The thrust reverse includes a deflector device which deflects all or part of the primary stream gas in such a manner that the deflected primary stream gas encounters the secondary stream, thereby reducing the injection speed of the secondary stream in an aft direction, and thus generating the thrust-reversal effect. The secondary stream escapes from the aft end of the nacelle. In the thrust-reversal position, the deflector device is inscribed radially substantially within the section of the primary nozzle cowl at the aft end of the nacelle. Such a thrust reverser is particularly simple in design, inexpensive, and makes it possible to avoid having moving parts present on the outside portion of the nacelle, thus simplifying the design of the turbojet.
摘要翻译: 公开了一种包括推力反向器的旁路涡轮喷气发动机。 推力反向包括偏转器装置,其以全部或部分主流气体的方式偏转,使得偏转的一次流气体遇到二次流,由此降低二次流在后方向上的喷射速度,从而产生 推力反转效应。 次级气流从机舱的后端排出。 在推力反转位置,偏转装置在机舱的后端基本上位于主喷嘴罩的部分内。 这种推力反向器在设计上特别简单,价格便宜,并且可以避免在机舱的外部存在移动部件,从而简化了涡轮喷气发动机的设计。
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公开(公告)号:US6011032A
公开(公告)日:2000-01-04
申请号:US11207
申请日:1998-01-26
申请人: Jean-Pierre Rieu , Jean-Fran.cedilla.ois Patoiseau , Gareth W. John , Bruno Legrand , Jean-Pierre Valentin
发明人: Jean-Pierre Rieu , Jean-Fran.cedilla.ois Patoiseau , Gareth W. John , Bruno Legrand , Jean-Pierre Valentin
IPC分类号: A61K31/00 , A61K31/55 , A61K31/553 , A61K31/554 , A61P9/00 , A61P9/10 , C07D413/12 , C07D417/12 , A61K31/54 , A61K31/535 , C07D265/12 , C07D279/16
CPC分类号: C07D413/12 , C07D417/12
摘要: Substituted N-heterocyclyl-1-aryloxyalkyl-4-piperldineamines of formula (I) ##STR1## wherein each of R.sub.1 to R.sub.4, which are the same or different, is hydrogen, optionally branched C.sub.1-4 alkyl, optionally branched C.sub.1-4 alkyloxy, halo, nitro, hydroxy, or trifluoromethyl or trifluoromethoxyl; R.sub.5 is hydrogen, optionally branched C.sub.1-6 alkyl, optionally branched C.sub.7-12 phenylalkyl optionally substituted on the phenyl by one or more radicals having the same definition as R.sub.1 ; W and X are oxygen or sulphur; Y is C.sub.2-6 polymethylene or --CH.sub.2 --CH(OH)--CH.sub.2 --; and n is 0 or 1; and pure R or S isomers of said compounds, where applicable, as well as mixtures thereof, as well as therapeutically-acceptable organic or inorganic salts and hydrates of the compounds and a method for preparing the compounds and their use as drugs are all disclosed.
摘要翻译: PCT No.PCT / FR96 / 01176 Sec。 371日期1998年1月26日 102(e)1998年1月26日PCT PCT 1996年7月25日PCT公布。 出版物WO97 / 05134 日期1997年2月13日,式(I)的取代的N-杂环基-1-芳氧基烷基-4-哌嗪胺其中R 1至R 4各自相同或不同,为氢,任选支链C 1-4烷基,任选支链C1- 4-烷氧基,卤素,硝基,羟基或三氟甲基或三氟甲氧基; R 5是氢,任选支链的C 1-6烷基,任意支化的C 7-12苯基烷基,其在苯基上被一个或多个与R 1相同定义的基团取代; W和X是氧或硫; Y为C2-6多亚甲基或-CH2-CH(OH)-CH2-; 并且n为0或1; 并且所有化合物的纯R或S异构体,如适用,以及其混合物,以及化合物的治疗上可接受的有机或无机盐和水合物,以及制备化合物的方法及其作为药物的用途。
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公开(公告)号:US20080250770A1
公开(公告)日:2008-10-16
申请号:US12100603
申请日:2008-04-10
CPC分类号: F02K1/566 , F02K1/64 , F02K1/68 , F02K1/74 , Y02T50/671
摘要: A by-pass turbojet including a thrust reverser. The thrust reverse comprises deflector means for deflecting all or part of the primary stream gas in such a manner that the deflected primary stream gas encounters the secondary stream, thereby reducing the injection speed of the secondary stream in an aft direction, and thus generating the thrust-reversal effect. The secondary stream escapes from the aft end of the nacelle. In the thrust-reversal position, the deflector means are inscribed radially substantially within the section of the primary nozzle cowl at the aft end of the nacelle. Such a thrust reverser is particularly simple in design, inexpensive, and makes it possible to avoid having moving parts present on the outside portion of the nacelle, thus simplifying the design of the turbojet.
摘要翻译: 包括推力反向器的旁路涡轮喷气发动机。 推力反向包括偏转装置,用于以使得偏转的一次流气体遇到次流的方式偏转全部或一部分主流气体,从而降低次流在向后方向上的喷射速度,从而产生推力 反转效应。 次级气流从机舱的后端排出。 在推力反转位置,偏转器装置径向地内接在机舱的后端处的主喷嘴罩的部分内。 这种推力反向器在设计上特别简单,价格便宜,并且可以避免在机舱的外部存在移动部件,从而简化了涡轮喷气发动机的设计。
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