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26 条记录 (耗时 0.018 秒)

    Alkyl and acyl substituted quinolines
    3.
    发明授权
    Alkyl and acyl substituted quinolines 失效
    烷基和酰基取代的喹啉

    公开(公告)号：US5382572A

    公开(公告)日：1995-01-17

    申请号：US30187

    申请日：1993-03-01

    申请人： Adriano Afonso ,  Jay Weinstein ,  Margaret J. Gentles

    发明人： Adriano Afonso ,  Jay Weinstein ,  Margaret J. Gentles

    IPC分类号： A61K31/12 ,  A61K31/13 ,  A61K31/165 ,  A61K31/18 ,  A61K31/185 ,  A61K31/19 ,  A61K31/22 ,  A61K31/37 ,  A61K31/38 ,  A61K31/382 ,  A61K31/47 ,  A61K31/665 ,  A61K31/67 ,  A61K31/675 ,  A61P31/12 ,  C07C49/755 ,  C07D215/22 ,  C07D311/56 ,  C07D335/06

    CPC分类号： C07D215/22 ,  C07D311/56 ,  C07D335/06

    摘要： Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates; wherein:(A) X is selected from the group consisting of N--R.sup.3, O, S, and C(R.sup.3).sub.2 ;(B) R.sup.3 is selected from H and a range of substituents;(C) R.sup.1 is an etherifying or esterifying group;(D) R.sup.2 is selected from a range of substituents;(E) m is 0 or an integer from 1 to 4; and(F) R.sup.4 and R.sup.5 are the same and are selected from alkyl and acyl groups;together with the pharmaceutically acceptable salts of the compounds of Formula 1.0 that are acidic or basic.Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating a viral infection using compounds represented by Formula 1.0.

    摘要翻译： PCT No.PCT / US91 / 06251 Sec。 371日期1993年3月1日 102（e）1993年3月1日PCT PCT 1991年9月6日PCT公布。 出版物WO92 / 04326 日期：1992年3月19日。公开了可用作抗病毒剂的化合物，用于含有DNA的病毒如疱疹病毒。 化合物由式1.0表示：其药学上可接受的盐和溶剂合物; 其中：（A）X选自N-R3，O，S和C（R3）2; （B）R 3选自H和取代基的范围; （C）R1是醚化或酯化基团; （D）R2选自取代基的范围; （E）m为0或1〜4的整数; 和（F）R 4和R 5相同并且选自烷基和酰基; 以及式1.0化合物的药学上可接受的盐，它们是酸性或碱性的。 公开了含有由式1.0表示的化合物的药物组合物。 还公开了使用由式1.0表示的化合物治疗病毒感染的方法。

    Certain N-substituted 3-oximino-2,4-dioxoquinolin-2,4-(1H)diones useful for treating viral infections
    4.
    发明授权
    Certain N-substituted 3-oximino-2,4-dioxoquinolin-2,4-(1H)diones useful for treating viral infections 失效
    某些N-取代的3-肟基-2,4-二氧代喹啉-2,4-（1H）二酮可用于治疗病毒感染

    公开(公告)号：US5190956A

    公开(公告)日：1993-03-02

    申请号：US579919

    申请日：1990-09-07

    申请人： Adriano Afonso ,  Jay Weinstein ,  Margaret J. Gentles

    发明人： Adriano Afonso ,  Jay Weinstein ,  Margaret J. Gentles

    IPC分类号： C07D215/22 ,  C07D215/38 ,  C07D311/58 ,  C07D335/06 ,  C07D401/14 ,  C07D405/14

    CPC分类号： C07D215/22 ,  C07D215/38 ,  C07D311/58 ,  C07D335/06 ,  C07D401/14 ,  C07D405/14

    摘要： Compounds useful as antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are selected from the group consisting of: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.00 are disclosed. Also disclosed are methods of treating a viral infection using compounds represented by Formula 1.00The compounds of Formula 1.00 are also useful as intermediates to compounds of: ##STR2## Compounds of Formula 1.0 are useful as antiviral agents against the same viruses that the compounds of Formula 1.00 are useful against.

    摘要翻译： 公开了用作抗病毒药物的化合物，其可用于含有病毒的DNA，如疱疹病毒。 化合物选自：式1.00及其药学上可接受的盐和溶剂化物。 公开了含有式1.00表示的化合物的药物组合物。 还公开了使用式1.00表示的化合物治疗病毒感染的方法。式1.00的化合物也可用作以下化合物的中间体：式1.0的化合物可用作抗化学药剂，其针对相同的病毒，化合物 的1.00是有用的。

    Quinoline-diones
    5.
    发明授权
    Quinoline-diones 失效
    喹啉二恶英

    公开(公告)号：US5179093A

    公开(公告)日：1993-01-12

    申请号：US698204

    申请日：1991-05-10

    申请人： Adriano Afonso ,  Stuart W. McCombie ,  Jay Weinstein

    发明人： Adriano Afonso ,  Stuart W. McCombie ,  Jay Weinstein

    IPC分类号： C07D215/22 ,  C07D401/12

    CPC分类号： C07D215/22 ,  C07D401/12

    摘要： Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein, R is H, halogen, (C.sub.1 -C.sub.6) alkyl, N(C.sub.1 -C.sub.6 alkyl/aryl).sub.2, OH, O--(C.sub.1 -C.sub.6) alkyl/aryl, CH.sub.2 OH, COOH, COO-alkyl/aryl, SO.sub.2 NH.sub.2, or SO.sub.2 NH (C.sub.1 -C.sub.6 alkyl/aryl);R.sub.1 is C.sub.1 -C.sub.6 alkyl, cycloalkyl, C.sub.2 -C.sub.6 alkenyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, --CH.sub.2 -aryl, --CH.sub.2 -substituted aryl, --CH.sub.2 -heteroaryl, or --CH.sub.2 -substituted heteroaryl;R.sub.2 is H, C.sub.1 -C.sub.6 alkyl or aryl; ##STR2## is an aromatic ring or a heteroaromatic ring; and X is O or N-(alkyl/aryl/alkyl-aryl/alkoxylalkoxyaryl)are described. These compounds are useful as agents for treating viruses.

    摘要翻译： 式I的化合物或其药学上可接受的盐，其中R是H，卤素，（C 1 -C 6）烷基，N（C 1 -C 6烷基/芳基）2，OH，O-（C 1 -C 6）烷基 芳基，CH 2 OH，COOH，COO-烷基/芳基，SO 2 NH 2或SO 2 NH（C 1 -C 6烷基/芳基）; R 1是C 1 -C 6烷基，环烷基，C 2 -C 6烯基，杂芳基，取代的杂芳基，杂环烷基，-CH 2 - 芳基，-CH 2 - 取代的芳基，-CH 2 - 杂芳基或-CH 2 - 取代的杂芳基; R2是H，C1-C6烷基或芳基; 是芳环或杂芳环; 并且X是O或N-（烷基/芳基/烷基 - 芳基/烷氧基烷氧基芳基）。 这些化合物可用作治疗病毒的药剂。

    Adaptive object level locking
    8.
    发明授权
    Adaptive object level locking 失效
    自适应对象级别锁定

    公开(公告)号：US07594053B2

    公开(公告)日：2009-09-22

    申请号：US10996877

    申请日：2004-11-23

    申请人： Mike Dvorkin ,  Jay Weinstein ,  Serge Krasnyansky

    发明人： Mike Dvorkin ,  Jay Weinstein ,  Serge Krasnyansky

    IPC分类号： G06F12/00 ,  G06F17/30

    CPC分类号： G06F9/526 ,  Y10S707/99938

    摘要： Providing concurrent access to a set of shared resources is disclosed. An attempt is made, at the time it becomes necessary to use each resource required to perform an operation or set of operations, to lock the resource. For each attempt to lock a required resource, information associated with the attempt to lock the resource is stored. In the event a lock cannot be obtained with respect to a required resource, a renewed attempt to perform the operation or set of operations is initiated. At the outset of the renewed attempt, an attempt is made to lock all of the required resources that were locked or attempted to be lock during the previous attempt to perform the operation or set of operations.

    摘要翻译： 提供对一组共享资源的并发访问。 当有必要使用执行操作或一组操作所需的每个资源来锁定资源时。 对于每次尝试锁定所需资源，存储与尝试锁定资源相关联的信息。 在不能获得相对于所需资源的锁定的情况下，启动执行操作或操作集合的再次尝试。 在重新尝试的一开始，试图锁定在先前尝试执行操作或一组操作时锁定或尝试锁定的所有必需资源。

    Adaptive object level locking
    9.
    发明申请
    Adaptive object level locking 失效
    自适应对象级别锁定

    公开(公告)号：US20050131899A1

    公开(公告)日：2005-06-16

    申请号：US10996877

    申请日：2004-11-23

    申请人： Mike Dvorkin ,  Jay Weinstein ,  Serge Krasnyansky

    发明人： Mike Dvorkin ,  Jay Weinstein ,  Serge Krasnyansky

    IPC分类号： G06F9/46 ,  G06F7/00

    CPC分类号： G06F9/526 ,  Y10S707/99938

    摘要： Providing concurrent access to a set of shared resources is disclosed. An attempt is made, at the time it becomes necessary to use each resource required to perform an operation or set of operations, to lock the resource. For each attempt to lock a required resource, information associated with the attempt to lock the resource is stored. In the event a lock cannot be obtained with respect to a required resource, a renewed attempt to perform the operation or set of operations is initiated. At the outset of the renewed attempt, an attempt is made to lock all of the required resources that were locked or attempted to be lock during the previous attempt to perform the operation or set of operations.

    摘要翻译： 提供对一组共享资源的并发访问。 当有必要使用执行操作或一组操作所需的每个资源来锁定资源时。 对于每次尝试锁定所需资源，存储与尝试锁定资源相关联的信息。 在不能获得相对于所需资源的锁定的情况下，启动执行操作或操作集合的再次尝试。 在重新尝试的一开始，试图锁定在先前尝试执行操作或一组操作时锁定或尝试锁定的所有必需资源。

    Antiviral compounds and antihypertensive compounds
    10.
    发明授权
    Antiviral compounds and antihypertensive compounds 失效
    抗病毒化合物和抗高血压化合物

    公开(公告)号：US5175151A

    公开(公告)日：1992-12-29

    申请号：US830958

    申请日：1992-02-05

    申请人： Adriano Afonso ,  Jay Weinstein ,  Margaret J. Gentles

    发明人： Adriano Afonso ,  Jay Weinstein ,  Margaret J. Gentles

    IPC分类号： C07D215/22 ,  C07D215/56 ,  C07D311/18 ,  C07F7/18

    CPC分类号： C07D215/22 ,  C07D215/56 ,  C07D311/18 ,  C07F7/1856

    摘要： Compounds useful as antihypertensive agents, or antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating hypertension or a viral infection using compounds represented by Formulas 1.0.Also disclosed is a compound of Structure B ##STR2## useful as an intermediate in producing compounds of Formula 1.0. A process for preparing the compounds of Formula 1.0 is also disclosed. In the process a compound of Structure B ##STR3## is reacted with an alkoxide R.sub.1 O.sup.- M.sup.+ in a solvent comprising the corresponding alcohol R.sub.1 OH of the alkoxide. Optionally, an organic cosolvent may be used with the solvent.

    摘要翻译： 公开了可用作抗高血压剂的化合物或抗DNA病毒的抗病毒剂如疱疹病毒。 化合物由式1.0表示：其中药学上可接受的盐和溶剂合物。 公开了含有由式1.0表示的化合物的药物组合物。 还公开了使用由式1.0表示的化合物治疗高血压或病毒感染的方法。 还公开了可用作制备式1.0化合物的中间体的结构B B的化合物。 还公开了制备式1.0化合物的方法。 在该方法中，将结构B B的化合物与醇盐R 1 O-M +在包含醇盐的相应醇R 1 OH的溶剂中反应。 任选地，有机共溶剂可以与溶剂一起使用。