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1.发明授权公开(公告)号：US08409607B2
公开(公告)日：2013-04-02
申请号：US12029425
申请日：2008-02-11
申请人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffery L. Edelman , Joan-En Chang-Lin , Jane-Guo Shiah , Thierry Nivaggioli
发明人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffery L. Edelman , Joan-En Chang-Lin , Jane-Guo Shiah , Thierry Nivaggioli
IPC分类号： A61F2/02
CPC分类号： A61K9/0051 , A61K9/1647 , Y10T428/2985
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
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2.发明授权公开(公告)号：US08404267B2
公开(公告)日：2013-03-26
申请号：US12029424
申请日：2008-02-11
申请人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffery L. Edelman , Joan-En Chang-Lin , Jane-Guo Shiah , Thierry Nivaggioli
发明人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffery L. Edelman , Joan-En Chang-Lin , Jane-Guo Shiah , Thierry Nivaggioli
IPC分类号： A61F2/02
CPC分类号： A61K9/0051 , A61K9/1647 , Y10T428/2985
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
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公开(公告)号：US20120207810A1
公开(公告)日：2012-08-16
申请号：US13396946
申请日：2012-02-15
申请人： Lon T. SPADA , Jane Guo SHIAH , Patrick HUGHES , Thomas C. MALONE , Gerald W. DEVRIES , Jeffrey L. EDELMAN , Julie A. WURSTER
发明人： Lon T. SPADA , Jane Guo SHIAH , Patrick HUGHES , Thomas C. MALONE , Gerald W. DEVRIES , Jeffrey L. EDELMAN , Julie A. WURSTER
IPC分类号： A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/443 , A61K31/695 , A61K31/497 , A61K31/541 , A61K31/4545 , A61P27/06 , A61P27/02 , A61K9/00 , A61K31/5377
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。
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4.发明授权Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods 有权含有酪氨酸激酶抑制剂的持续释放眼内植入物及相关方法公开(公告)号：US07771742B2
公开(公告)日：2010-08-10
申请号：US10837361
申请日：2004-04-30
申请人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffrey L. Edelman , Joan-En Chang-Lin , Jane Guo Shiah , Thierry Nivaggioli
发明人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffrey L. Edelman , Joan-En Chang-Lin , Jane Guo Shiah , Thierry Nivaggioli
IPC分类号： A61F2/14
CPC分类号： A61K9/0051 , A61K9/1647 , Y10T428/2985
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
摘要翻译： 生物相容性眼内植入物包括酪氨酸激酶抑制剂和生物可降解聚合物，其有效促进酪氨酸激酶抑制剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生。
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公开(公告)号：US20050048099A1
公开(公告)日：2005-03-03
申请号：US10918597
申请日：2004-08-13
申请人： Jane-Guo Shiah , Rahul Bhagat , Thierry Nivaggioli , Lin Peng , David Chou , David Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Thierry Nivaggioli , Lin Peng , David Chou , David Weber
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
摘要翻译： 本发明提供了适于植入眼部区域的可生物降解的植入物以及用于治疗眼睛的医学状况的方法。 植入物由亲水末端和疏水末端PLGA的混合物形成，并且将活性剂递送到眼部区域而没有高突释。
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公开(公告)号：US20110263611A1
公开(公告)日：2011-10-27
申请号：US13178277
申请日：2011-07-07
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
IPC分类号： A61K31/496 , A61P27/06 , A61K31/5377 , A61P27/02
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。
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7.发明申请SUSTAINED RELEASE INTRAOCULAR IMPLANTS CONTAINING TYROSINE KINASE INHIBITORS AND RELATED METHODS 有权含有酪氨酸激酶抑制剂的持续释放内皮植入物及相关方法公开(公告)号：US20080254096A1
公开(公告)日：2008-10-16
申请号：US12029425
申请日：2008-02-11
申请人： Patrick M. HUGHES , Thomas C. MALONE , Gerald W. DE VRIES , Jeffery L. EDELMAN , Joan-En CHANG-LIN , Jane Guo SHIAH , Thierry NIVAGGIOLI
发明人： Patrick M. HUGHES , Thomas C. MALONE , Gerald W. DE VRIES , Jeffery L. EDELMAN , Joan-En CHANG-LIN , Jane Guo SHIAH , Thierry NIVAGGIOLI
CPC分类号： A61K9/0051 , A61K9/1647 , Y10T428/2985
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
摘要翻译： 生物相容性眼内植入物包括酪氨酸激酶抑制剂和生物可降解聚合物，其有效促进酪氨酸激酶抑制剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生。
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8.发明申请Estradiol derivative and estratopone containing sustained release intraocular implants and related methods 审中-公开雌二醇衍生物和雌激素含持续释放眼内植入物及相关方法公开(公告)号：US20050244471A1
公开(公告)日：2005-11-03
申请号：US10837379
申请日：2004-04-30
申请人： Jane Guo Shiah , Paul Dickinson
发明人： Jane Guo Shiah , Paul Dickinson
CPC分类号： A61K9/0051 , A61K9/204 , A61K31/565
摘要： Biocompatible intraocular implants include an anti-angiogenic agent, such as estradiol derivative or an estratopone and a biodegradable polymer that is effective to facilitate release of the anti-angiogenic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as angiogenisis, ocular tumors, and the like.
摘要翻译： 生物相容性眼内植入物包括抗血管生成剂，例如雌二醇衍生物或雌激素和可生物降解的聚合物，其有效促进抗血管生成剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症（例如血管生成，眼部肿瘤等）的发生。
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公开(公告)号：US08512738B2
公开(公告)日：2013-08-20
申请号：US11119001
申请日：2005-04-29
申请人： Jeffrey L. Edelman , Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Joan-En Chang-Lin , Jane Guo Shiah , Thierry Nivaggioli , Lon T. Spada , Wendy M. Blanda
发明人： Jeffrey L. Edelman , Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Joan-En Chang-Lin , Jane Guo Shiah , Thierry Nivaggioli , Lon T. Spada , Wendy M. Blanda
IPC分类号： A61F2/14
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/204 , A61K31/404 , A61K31/454 , A61K31/5377 , A61K47/34
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.
摘要翻译： 生物相容性眼内植入物包括酪氨酸激酶抑制剂和可生物降解的聚合物，其有效促进酪氨酸激酶抑制剂延长一段时间的眼睛玻璃体。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症如眼后病症的发生。
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公开(公告)号：US08318070B2
公开(公告)日：2012-11-27
申请号：US13224041
申请日：2011-09-01
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
IPC分类号： B29C47/04
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
摘要翻译： 本发明提供了适于植入眼部区域的可生物降解的植入物以及用于治疗眼睛的医学状况的方法。 植入物由亲水末端和疏水末端PLGA的混合物形成，并且将活性剂递送到眼部区域而没有高突释。
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