公开(公告)号：US5824651A

公开(公告)日：1998-10-20

申请号：US672243

申请日：1996-06-28

申请人： Antonio Nanci ,  Marc D. McKee ,  Edward Sacher ,  Oumarou Savadogo ,  James Wuest

发明人： Antonio Nanci ,  Marc D. McKee ,  Edward Sacher ,  Oumarou Savadogo ,  James Wuest

IPC分类号： A61L27/28 ,  A61L27/54 ,  A61K38/18 ,  A61F2/28 ,  A61K38/39 ,  B05D3/04

CPC分类号： B82Y30/00 ,  A61L27/28 ,  A61L27/54 ,  B82Y10/00 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/606

摘要： The present invention relates to a process for the covalent coating of implants with a bioactive conjugate, which comprises the steps of: a) cleaning a metal implant surface from contaminants by deoxidation with potentiostatic electrochemical polishing in a solution selected from ethanol, perchloric acid-butanol-methanol solution, H.sub.2 O.sub.2 --NaCl--NaH.sub.2 PO.sub.4 or by chemical cleaning with a solution selected from the group consisting of HF/HNO.sub.3, H.sub.2 O.sub.2 /H.sub.2 SO.sub.4 and H.sub.2 O.sub.2 /KOH; b) coating the cleaned implant surface of step a) with a bioactive conjugate, wherein the conjugate has the following structural Formula I: --R--X--P I wherein, R is O or S, adapted to be covalently attached to an implant surface; X is selected from a bond, linear or branched chains of 1 to 30 covalently attached atoms of at least C, N, O, Si or S, rings of 1 to 20 covalently attached atoms of at least C, N, O, Si or S, and a combination thereof; and P is a bioactive molecule moiety which promotes tissue growth, stabilization and integration, and wherein the moiety retains its biological activity.

摘要翻译： 本发明涉及用生物活性缀合物共价涂覆植入物的方法，其包括以下步骤：a）通过在选自乙醇，高氯酸丁醇中的溶液中用恒电位电化学抛光将脱金属物质从污染物中清除 或通过用选自HF / HNO 3，H 2 O 2 / H 2 SO 4和H 2 O 2 / KOH的溶液进行化学清洗来进行化学清洗。 b）用生物活性缀合物涂覆步骤a）的清洁的植入物表面，其中缀合物具有以下结构式I：-R-X-PI，其中R是O或S，适于共价连接到植入物表面; X选自至少C，N，O，Si或S的共价连接的原子至少为1至30个的共价连接的原子的至少C，N，O，Si或1至20个共价连接的原子的至少C，N，O，Si或 S及其组合; 并且P是促进组织生长，稳定和整合的生物活性分子部分，并且其中该部分保留其生物学活性。

公开(公告)号：US20060149063A1

公开(公告)日：2006-07-06

申请号：US10794930

申请日：2004-03-05

申请人： Danielle Boils-Boissier ,  Marcel Breton ,  Jule Thomas ,  Donald Titterington ,  Jeffrey Banning ,  H. Goodbrand ,  James Wuest ,  Marie-Eve Perron ,  Hugues Duval

发明人： Danielle Boils-Boissier ,  Marcel Breton ,  Jule Thomas ,  Donald Titterington ,  Jeffrey Banning ,  H. Goodbrand ,  James Wuest ,  Marie-Eve Perron ,  Hugues Duval

IPC分类号： C07D403/02 ,  C07D239/47

CPC分类号： C07D239/47 ,  C09D11/34

摘要： Compounds of the formulae wherein, provided that at least one of R1, R2, and R3 is not a hydrogen atom, R1, R2, and R3 each, independently of the other, is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, and wherein R1 and R2 can also be alkoxy aryloxy, arylalkyloxy, alkylaryloxy, polyalkyleneoxy, polyaryleneoxy, polyarylalkyleneoxy, polyalkylaryleneoxy, silyl, siloxane, polysilylene, polysiloxane, or a group of the formula wherein r and s are integers representing a number of repeat —CH2— groups, and wherein X is a direct bond, oxygen, sulfur, —NR40— wherein R40 is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, or —CR50R60— wherein R50 and R60 each, independently of the other, is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, and R10 and R11 each, independently of the other, is alkylene, arylene, arylalkylene, or alkylarylene, and wherein R10 can also be alkyleneoxy, polyaryleneoxy, polyarylalkyleneoxy, polyalkylaryleneoxy, silylene, siloxane, polysilylene, or polysiloxane.

摘要翻译： 下式的化合物其中，只要R 1，R 2和R 3 3中的至少一个不是氢原子， 各自独立地为氢，烷基，芳基，芳基烷基或烷基芳基，其中R 1，R 2，R 3和R 3各自独立地为氢，烷基，芳基， R 1和R 2也可以是烷氧基芳氧基，芳基烷氧基，烷芳基氧基，聚亚烷氧基，聚亚芳基氧基，聚芳基亚烷基氧基，聚烷基亚芳基氧基，甲硅烷基，硅氧烷，聚亚芳基，聚硅氧烷或式 其中r和s是代表多个重复-CH 2 - 基团的整数，并且其中X是直接键，氧，硫，-NR 40 - ，其中R' 其中R 50是氢，烷基，芳基，芳基烷基或烷基芳基，或-CR 50 R 60 - ，其中R 50是氢， 和R 60各自独立地为氢，烷基，芳基，芳烷基或烷芳基，R 10和R 11各自独立地为 独立地是亚烷基，亚芳基，芳基 亚烷基或烷基亚芳基，其中R 10也可以是亚烷基氧基，聚亚芳基氧基，聚芳基亚烷氧基，聚烷基亚芳基氧基，亚甲硅烷基，硅氧烷，聚亚芳基或聚硅氧烷。

公开(公告)号：US20060178531A1

公开(公告)日：2006-08-10

申请号：US11363925

申请日：2006-02-28

申请人： Marcel Breton ,  Danielle Boils-Boissier ,  Jule Thomas ,  Donald Titterington ,  H. Goodbrand ,  Jeffrey Banning ,  James Wuest ,  Dominic Laliberte ,  Marie-Eve Perron

发明人： Marcel Breton ,  Danielle Boils-Boissier ,  Jule Thomas ,  Donald Titterington ,  H. Goodbrand ,  Jeffrey Banning ,  James Wuest ,  Dominic Laliberte ,  Marie-Eve Perron

IPC分类号： C07C275/36

CPC分类号： C07D251/70 ,  C07C275/34 ,  C09D11/34

摘要： Compounds of the formulae wherein Z is —OR1, —SR1, —NR1R2, Y is —OR3, —SR3, or —NR3R4, at least one of R1, R2, R3, R4, R5, and R6 is hydrogen, at least one of R1, R2, R3, R4, R5, and R6 is other than hydrogen, at least one Z or Y within the compound is —NR1R2 or —NR3R4, R1, R2, R3, R4, R5, R6, and R7 each, independently of the others, is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, and wherein R7 can also be alkoxy, aryloxy, arylalkyloxy, alkylaryloxy, polyalkyleneoxy, polyaryleneoxy, polyarylalkyleneoxy, polyalkylaryleneoxy, silyl, siloxane, polysilylene, polysiloxane, or wherein X is a direct bond, oxygen, sulfur, —NR40— wherein R40 is hydrogen, alkyl, aryl, arylalkyl, alkylaryl, or —CR50R60— wherein R50 and R60 each, independently of the other, is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl.

摘要翻译： 下式的化合物其中Z为-OR 1，-SR 1，-NR 1 R 2，Y 是-OR 3，-SR 3或-NR 3 R 4，R 1，R 3， R 1，R 2，R 3，R 4，R 5，R 3，R 5，R 5， R 6是氢，R 1，R 2，R 3，R 4中的至少一个是 R 5，R 6和R 6不是氢，化合物中至少一个Z或Y是-NR 1 N， R 2或-NR 3 R 4，R 1，R 2，R 2， R 3，R 4，R 5，R 6和R 7， 各自独立地为氢，烷基，芳基，芳基烷基或烷基芳基，并且其中R 7也可以是烷氧基，芳氧基，芳基烷氧基，烷芳基氧基，聚亚烷氧基，聚亚芳基氧基，聚芳基亚烷氧基，聚烷基亚芳基氧基，甲硅烷基 ，硅氧烷，聚亚硅烷基，聚硅氧烷，或其中X是直接键，氧，硫，-NR 40 - ， - R 40是氢，烷基，芳基，芳烷基，烷基芳基或-CR 50 R 60 - ，其中R 50是氢， 各自独立地是氢，烷基，芳基，芳基烷基或烷基芳基。