公开(公告)号：US6159159A

公开(公告)日：2000-12-12

申请号：US224182

申请日：1998-12-31

Applicant: Joseph M. Canter ,  Yongwu Yang ,  Wanglong Zhou ,  Victor S. Sapirstein ,  Melvin P. Ehrlich ,  James S. Harrison ,  Eugene Katsman ,  Omanand Koul ,  Michael Y. Lu ,  Michael A. Greenwald

Inventor： Joseph M. Canter ,  Yongwu Yang ,  Wanglong Zhou ,  Victor S. Sapirstein ,  Melvin P. Ehrlich ,  James S. Harrison ,  Eugene Katsman ,  Omanand Koul ,  Michael Y. Lu ,  Michael A. Greenwald

IPC: A61B10/00

CPC classification number: A61B10/0012 ,  A61B2010/0025 ,  Y10S436/906

Abstract: A quantitative process for monitoring female fertility cycle wherein the process involves directing a laser beam, preferably generated by a diode laser, onto an area of a slide containing an air-dried sample of a female body fluid. The diffraction pattern resulting from the sample is detected by a two-dimensional photo diode array and analyzed by a microprocessor. If a ferning pattern exists, such pattern will generate a characteristic structure in the diffraction pattern which is then detected by the photo diode array. If no ferning occurs, the corresponding diffraction pattern will be structureless. The microprocessor is programmed with an algorithm to produce a quantitative index of ferning indicating quantitatively the ferning level. Preferably, a plurality of spots on the sample are measured to determine the ferning level at each spot, and the microprocessor then makes a final determination as to final ferning level on the basis of the test results of all of the spots. This significantly increases the reliability of the final test result, since a defect at one test spot or anomaly of one test result will not be fatal to the final result.

Abstract translation: 一种用于监测雌性生育周期的定量过程，其中该方法包括将优选由二极管激光产生的激光束引导到含有女性体液的空气干燥样品的载玻片的区域上。 由样品产生的衍射图由二维光电二极管阵列检测并由微处理器分析。 如果存在镀层图案，则这种图案将产生衍射图案中的特征结构，然后由光电二极管阵列检测。 如果没有发生发光，相应的衍射图将是无结构的。 微处理器用一种算法进行编程，以产生定量指定的定量指标。 优选地，测量样品上的多个点以确定每个点处的熨烫水平，然后微处理器基于所有点的测试结果对最终熨烫水平进行最终确定。 这显着增加了最终测试结果的可靠性，因为一个测试点的缺陷或一个测试结果的异常对最终结果不会是致命的。

公开(公告)号：US4578282A

公开(公告)日：1986-03-25

申请号：US688975

申请日：1985-01-04

Applicant: James S. Harrison

Inventor： James S. Harrison

IPC: G01N1/30 ,  G01N33/04 ,  G01N33/545 ,  G01N33/552

CPC classification number: G01N1/30 ,  G01N2001/307 ,  G01N33/04

Abstract: A fixative composition for histological, cytological, immunological and proteinaceous preparations comprising a mixture of pyrrolid-2-one, a polyol, a urea and a zinc salt of a non-oxidizing organic or inorganic acid. Also disclosed are devices utilizing such compositions.

Abstract translation: 用于组织学，细胞学，免疫学和蛋白质制剂的固定组合物，其包含非氧化性有机或无机酸的吡咯烷-2-酮，多元醇，脲和锌盐的混合物。 还公开了利用这种组合物的装置。

公开(公告)号：US3997656A

公开(公告)日：1976-12-14

申请号：US596010

申请日：1975-07-15

Applicant: Paul T. Wertlake ,  James S. Harrison

Inventor： Paul T. Wertlake ,  James S. Harrison

IPC: A01N1/02 ,  G01N1/30 ,  G01N1/00

CPC classification number: G01N1/30 ,  A01N1/0231 ,  G01N2001/305

Abstract: A superior and extremely rapid histological staining method is described in which frozen tissue is briefly immersed in an aqueous solution comprising trichloroacetic acid, zinc chloride and formaldehyde and then in a second solution comprising hematoxylin. The tissue can be further counterstained if desired. Also disclosed are improved fixatives useful in this and other histological techniques.

Abstract translation: 描述了一种优异且极其迅速的组织学染色方法，其中将冷冻组织短暂地浸入包含三氯乙酸，氯化锌和甲醛的水溶液中，然后在包含苏木精的第二溶液中浸渍。 如果需要，可以对组织进行再染色。 还公开了在该和其他组织学技术中有用的改进的固定剂。

公开(公告)号：US4493821A

公开(公告)日：1985-01-15

申请号：US345589

申请日：1982-02-04

Applicant: James S. Harrison

Inventor： James S. Harrison

IPC: G01N33/48 ,  G01N1/30 ,  G01N33/04 ,  G01N33/531 ,  G01N31/00 ,  C09K3/00 ,  C09K15/00 ,  G01N33/52

CPC classification number: G01N1/30 ,  G01N2001/307 ,  G01N33/04 ,  Y10T436/107497 ,  Y10T436/108331

Abstract: A fixative composition for histological, cytological, immunological and proteinaceous preparations comprising a mixture of pyrrolid-2-one, a polyol, a urea and a zinc salt of a non-oxidizing organic or inorganic acid. Also disclosed are devices utilizing such compositions.

Abstract translation: 用于组织学，细胞学，免疫学和蛋白质制剂的固定组合物，其包含非氧化性有机或无机酸的吡咯烷-2-酮，多元醇，脲和锌盐的混合物。 还公开了利用这种组合物的装置。

公开(公告)号：US3945523A

公开(公告)日：1976-03-23

申请号：US567990

申请日：1975-04-14

Applicant: Paul T. Wertlake ,  James S. Harrison

Inventor： Paul T. Wertlake ,  James S. Harrison

IPC: A61J1/00 ,  A61J1/05 ,  B65D1/00 ,  B65D81/18

CPC classification number: A61J1/05 ,  B65D1/00 ,  B65D81/18 ,  Y10S215/03

Abstract: A system for the transferral, freezing, storage and processing of liquids with a minimum of contamination is described. The components of the system include a hollow disc-shaped vessel of special construction which permits rapid freezing at extremely low temperatures, a pierceable, resilient sealing member on the ports of the disc-shaped vessel and a pointed cannular needle which is protected from contamination prior to use and operable to pierce the sealing member free of any contamination.

Abstract translation: 描述了一种用于传送，冷冻，储存和加工具有最少污染的液体的系统。 系统的部件包括特殊结构的中空圆盘形容器，其允许在极低温度下快速冷冻，在圆盘形容器的端口上形成可刺破的弹性密封件，以及一个被预防污染的尖头针管 使用和可操作地刺穿密封构件而没有任何污染。