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公开(公告)号：US20130261729A1
公开(公告)日：2013-10-03
申请号：US13436527
申请日：2012-03-30
申请人： Matthew Gillick , Yunbing Wang , Justin Mann , Bruce Wilson , James Oberhauser
发明人： Matthew Gillick , Yunbing Wang , Justin Mann , Bruce Wilson , James Oberhauser
IPC分类号： A61F2/84
CPC分类号： A61F2/958 , A61F2250/0013 , A61M25/10181 , A61M25/10185
摘要： An apparatus and method for controlling inflation pressure and pressurization rate of a balloon during deployment of a stent or scaffold is disclosed.
摘要翻译： 公开了一种用于在展开支架或支架期间控制气囊的充气压力和加压速率的装置和方法。
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2.发明授权Stents including poly(L-lactide) formulations that minimize molecular weight drop during processing 有权支架，包括聚（L-丙交酯）制剂，使加工过程中的分子量下降最小化公开(公告)号：US08529617B2
公开(公告)日：2013-09-10
申请号：US13481523
申请日：2012-05-25
申请人： Byron Lambert , Yunbing Wang , James Oberhauser
发明人： Byron Lambert , Yunbing Wang , James Oberhauser
IPC分类号： A61F2/06
CPC分类号： B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
摘要： A stent scaffolding including a polymer formulation comprising PLLA and polymandelide is disclosed. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
摘要翻译： 公开了一种包括含有PLLA和聚扁桃酸酯的聚合物制剂的支架支架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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3.发明申请STENTS INCLUDING POLY(L-LACTIDE) FORMULATIONS THAT MINIMIZE MOLECULAR WEIGHT DROP DURING PROCESSING 有权包括在加工过程中最小化分子量降低的聚（L-柠檬酸）配方的方法公开(公告)号：US20120239135A1
公开(公告)日：2012-09-20
申请号：US13481523
申请日：2012-05-25
申请人： Byron Lambert , Yunbing Wang , James Oberhauser
发明人： Byron Lambert , Yunbing Wang , James Oberhauser
CPC分类号： B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
摘要： A stent scaffolding including a polymer formulation comprising PLLA and polymandelide is disclosed. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
摘要翻译： 公开了一种包括含有PLLA和聚扁桃酸酯的聚合物制剂的支架支架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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公开(公告)号：US08006568B2
公开(公告)日：2011-08-30
申请号：US12819117
申请日：2010-06-18
IPC分类号： G01D21/00
CPC分类号： G01N3/04 , G01N2203/0017 , G01N2203/0089 , G01N2203/0222 , G01N2203/0274 , G01N2203/0435
摘要： A test fixture for use with a Dynamic Mechanical Analyzer (DMA) restrains a hollow cylindrical tube for purposes of performing either a tensile or transverse/bending load test. The fixture includes a clamp that is configured to restrain the tube without imparting a preload or changing a mechanical property of the tube.
摘要翻译： 用于动态机械分析仪（DMA）的测试夹具限制了空心圆柱形管，用于进行拉伸或横向/弯曲载荷试验。 夹具包括夹持器，其被构造成约束管而不赋予管的预加载力或改变管的机械性能。
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5.发明申请Method To Minimize Molecular Weight Drop Of Poly(L-Lactide) Stent During Processing 有权减少加工过程中聚（L-丙交酯）支架分子量下降的方法公开(公告)号：US20110065825A1
公开(公告)日：2011-03-17
申请号：US12559402
申请日：2009-09-14
申请人： Byron Lambert , Yunbing Wang , James Oberhauser
发明人： Byron Lambert , Yunbing Wang , James Oberhauser
IPC分类号： C08J3/28
CPC分类号： B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
摘要： A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
摘要翻译： 公开了减少或最小化处理期间支架分子量降低的方法。 支架具有包括PLLA和聚扁桃酸酯的聚合物制剂的脚手架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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公开(公告)号：US20110062638A1
公开(公告)日：2011-03-17
申请号：US12559400
申请日：2009-09-14
申请人： Thierry Glauser , Vincent Gueriguian , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner
发明人： Thierry Glauser , Vincent Gueriguian , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner
CPC分类号： B29D22/00 , A61F2/91 , B29C49/0005 , B29C49/02 , B29C49/04 , B29C49/08 , B29C49/78 , B29C55/26 , B29C2793/009 , B29K2995/004 , B29K2995/0041 , B29K2995/0046 , B29K2995/0056 , B29K2995/006 , B29K2995/0077 , B29K2995/0089 , B29L2031/7542
摘要： Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stent manufacture and fabrication of a stent therefrom are disclosed.
摘要翻译： 公开了扩展聚合物管的方法，其具有用于支架制造和制造支架的所需或最佳形态和机械性能。
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公开(公告)号：US20110022155A1
公开(公告)日：2011-01-27
申请号：US12506973
申请日：2009-07-21
申请人： Yunbing Wang , James Oberhauser , Xiao Ma
发明人： Yunbing Wang , James Oberhauser , Xiao Ma
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61F2/82 , A61L31/06 , B23K26/402 , B23K2103/42 , B23K2103/50 , C08L67/04
摘要： A biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.
摘要翻译： 公开了由聚（L-丙交酯）和低浓度的L-丙交酯单体制成的可生物降解的聚合物支架。 调节L-丙交酯的浓度以提供适合于包括冠状动脉，外周和鼻部在内的不同治疗应用的降解行为。
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公开(公告)号：US09889238B2
公开(公告)日：2018-02-13
申请号：US12506973
申请日：2009-07-21
申请人： Yunbing Wang , James Oberhauser , Xiao Ma
发明人： Yunbing Wang , James Oberhauser , Xiao Ma
IPC分类号： A61F2/82 , A61L31/14 , A61L31/06 , B23K26/402 , B23K103/00
CPC分类号： A61L31/148 , A61F2/82 , A61L31/06 , B23K26/402 , B23K2103/42 , B23K2103/50 , C08L67/04
摘要： A biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.
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9.发明授权Method and system for manufacturing a polymer endoprosthesis by injection molding and blow molding 有权通过注塑和吹塑制造聚合物内置假体的方法和系统公开(公告)号：US08747728B2
公开(公告)日：2014-06-10
申请号：US13114941
申请日：2011-05-24
申请人： Yunbing Wang , James Oberhauser
发明人： Yunbing Wang , James Oberhauser
IPC分类号： B29C49/06
CPC分类号： B29C49/06 , A61F2/91 , B29K2067/043 , B29K2067/046 , B29L2031/7532
摘要： A polymer endoprosthesis is fabricated by a combination of injection molding and blow molding which form a tubular substrate of polymer material, followed by laser cutting, crimping and sterilization. After the injection and blow molding processes, a subtractive process is performed on the tubular substrate to transform it into a stent having a network of stent struts. The tubular substrate can be made in an injection mold and blow mold which are attached to each other. The transition from injection molding and blow molding can be performed while the injection molded substrate remains at a temperature at or above Tg of the polymer material.
摘要翻译： 通过注射成型和吹塑成型的组合制造聚合物内用假体，其形成聚合物材料的管状基材，随后进行激光切割，卷曲和灭菌。 在注射和吹塑成型工艺之后，对管状基材进行减色处理以将其转变成具有支架支架网络的支架。 管状基板可以制造成彼此附接的注射模具和吹塑模具。 注射成型和吹塑成型的过渡可以在注塑基材保持在聚合物材料的Tg以上的温度下进行。
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10.发明申请Method and System for Manufacturing a Polymer Endoprosthesis by Injection Molding and Blow Molding 有权通过注射成型和吹塑制造聚合物内置假体的方法和系统公开(公告)号：US20120299226A1
公开(公告)日：2012-11-29
申请号：US13114941
申请日：2011-05-24
申请人： Yunbing Wang , James Oberhauser
发明人： Yunbing Wang , James Oberhauser
IPC分类号： B29C49/06
CPC分类号： B29C49/06 , A61F2/91 , B29K2067/043 , B29K2067/046 , B29L2031/7532
摘要： A polymer endoprosthesis is fabricated by a combination of injection molding and blow molding which form a tubular substrate of polymer material, followed by laser cutting, crimping and sterilization. After the injection and blow molding processes, a subtractive process is performed on the tubular substrate to transform it into a stent having a network of stent struts. The tubular substrate can be made in an injection mold and blow mold which are attached to each other. The transition from injection molding and blow molding can be performed while the injection molded substrate remains at a temperature at or above Tg of the polymer material.
摘要翻译： 通过注射成型和吹塑成型的组合制造聚合物内用假体，其形成聚合物材料的管状基材，随后进行激光切割，卷曲和灭菌。 在注射和吹塑成型工艺之后，对管状基材进行减色处理以将其转变成具有支架支架网络的支架。 管状基板可以制造成彼此附接的注射模具和吹塑模具。 注射成型和吹塑成型的过渡可以在注塑基材保持在聚合物材料的Tg以上的温度下进行。
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