公开(公告)号：US20090105150A1

公开(公告)日：2009-04-23

申请号：US12150101

申请日：2008-04-24

申请人： James Francis Glover ,  Arthur Rushton ,  Phillip John Morgan ,  Stephen Clinton Young

发明人： James Francis Glover ,  Arthur Rushton ,  Phillip John Morgan ,  Stephen Clinton Young

IPC分类号： A61K38/10 ,  A61K38/08 ,  C07K7/14 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  A61K31/7052 ,  A61P37/00

CPC分类号： C07K7/14 ,  A61K38/00 ,  A61K39/00 ,  A61K47/62 ,  C07K2319/00

摘要： An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with the renin activated angiotensin system.

摘要翻译： 包含与肽载体结合部分偶联的至少一种血管紧张素肽部分的血管紧张素衍生物，其可用于治疗和预防与肾素活化的血管紧张素系统相关的病症。

公开(公告)号：US20080318209A1

公开(公告)日：2008-12-25

申请号：US10588078

申请日：2005-01-27

申请人： Matthew Richard Downham ,  James Francis Glover ,  Rachel Emma Hanily

发明人： Matthew Richard Downham ,  James Francis Glover ,  Rachel Emma Hanily

IPC分类号： C12Q1/68

CPC分类号： G01N33/6896 ,  G01N2800/2828

摘要： The present invention provides an assay method for detecting infectious prion protein in a sample from a mammalian subject, said method comprising: obtaining a prion protein containing sample from said subject; contacting said sample with an agent which serves to digest non-infectious prion protein and to partially digest infected prion protein to yield a prion protein polypeptide residue; contacting the digested sample with an antibody capable of binding to a poly peptide having the amino acid sequence Vc (Gly-Gly-Gly-Trp)-Gly-Gln-Gly-Gly-R1-R2-His-R3-Gln-Trp-Asn-Lys-Pro-Lys-R4-Lys-Pro-Lys-Thr-R5-R6-Lys (-His-R7-Ala-Gly) (Vc) and detecting conjugates of said antibody and said prion protein polypeptide residue; characterized in that the detection of said conjugates comprises chemical, biological or biochemical amplification of a detectable species and detection of the amplified species.

摘要翻译： 本发明提供了一种用于检测来自哺乳动物受试者的样品中的感染性朊蛋白的测定方法，所述方法包括：从所述受试者获得含有朊病毒蛋白的样品; 使所述样品与用于消化非感染性朊病毒蛋白并部分消化感染的朊病毒蛋白以产生朊病毒蛋白多肽残基的试剂接触; 使消化的样品与能够结合具有氨基酸序列Vc（Gly-Gly-Gly-Trp）-Gly-Gln-Gly-Gly-R1-R2-His-R3-Gln-Trp- As-Lys-Pro-Lys-R4-Lys-Pro-Lys-Thr-R5-R6-Lys（-His-R7-Ala-Gly）（Vc）和检测所述抗体和所述朊蛋白多肽残基的缀合物; 其特征在于所述缀合物的检测包括可检测物种的化学，生物或生物化学扩增和扩增物种的检测。

公开(公告)号：US07378489B1

公开(公告)日：2008-05-27

申请号：US09470997

申请日：1999-12-23

申请人： James Francis Glover ,  Arthur Rushton ,  Phillip John Morgan ,  Stephen Clinton Young

发明人： James Francis Glover ,  Arthur Rushton ,  Phillip John Morgan ,  Stephen Clinton Young

IPC分类号： C07K7/14

CPC分类号： C07K7/14

摘要： An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with the renin activated angiotensin system.

摘要翻译： 包含与肽载体结合部分偶联的至少一种血管紧张素肽部分的血管紧张素衍生物，其可用于治疗和预防与肾素活化的血管紧张素系统相关的病症。