公开(公告)号：US20060222524A1

公开(公告)日：2006-10-05

申请号：US11162201

申请日：2005-08-31

Applicant: James Cook ,  James Cook

Inventor： James Cook ,  James Cook

IPC: F04B17/00

CPC classification number: F04B9/04 ,  F04B17/03

Abstract: A fluid pumping system that includes a motor and a pump, wherein an output shaft of the motor is directly coupled to an input shaft of the pump. This coupling between the output shaft of the motor and the input shaft of the pump may be the primary mechanism for coupling the motor to the pump. Such a configuration may be called a “floating pump mount”, because the pump is primarily coupled to the motor via the shaft connection. As a result of this connection, the output shaft of the motor may be naturally “aligned” with the input shaft of the pump. To help prevent the pump from freely rotating with the output shaft of the motor during operation, a rotational stop mechanism may be provided. The rotational stop mechanism may include a bracket that extends between the motor housing and the pump housing. The bracket may be adapted to absorb at least some of any relative movement between the pump and the motor caused by, for example, shaft or coupling irregularities.

Abstract translation: 一种包括马达和泵的流体泵送系统，其中马达的输出轴直接联接到泵的输入轴。 马达的输出轴与泵的输入轴之间的这种耦合可以是用于将马达耦合到泵的主要机构。 这种配置可以被称为“浮动泵安装座”，因为泵通过轴连接主要耦合到电动机。 作为这种连接的结果，马达的输出轴可以与泵的输入轴自然地“对准”。 为了在操作期间防止泵与电动机的输出轴自由旋转，可以设置旋转停止机构。 旋转停止机构可以包括在马达壳体和泵壳体之间延伸的支架。 支架可以适于吸收例如由轴或联接不规则引起的泵和电动机之间的任何相对运动中的至少一些。

公开(公告)号：US20180271922A1

公开(公告)日：2018-09-27

申请号：US15991546

申请日：2018-05-29

Applicant: Commonwealth Scientific and Industrial Research Organisation ,  Meat & Livestock Australia Limited ,  James Cook University

Inventor： Lorenna MACHADO ,  Marie Elisabeth MAGNUSSON ,  Nigel William TOMKINS ,  Robert Douglas KINLEY ,  Peter Canisius DENYS ,  Nicholas Andrew PAUL

IPC: A61K36/04 ,  A61K9/00 ,  A61P1/00 ,  A23K10/30 ,  A23K50/10

CPC classification number: A61K36/04 ,  A23K10/30 ,  A23K50/10 ,  A61K9/0056 ,  A61P1/00

Abstract: The present invention relates to a method of reducing total gas production and/or methane production in a ruminant animal.

公开(公告)号：US20160229905A1

公开(公告)日：2016-08-11

申请号：US15023165

申请日：2014-09-18

Applicant: JAMES COOK UNIVERSITY

Inventor： Alex Loukas ,  Andrew Leech ,  Darren Pickering

IPC: C07K14/81 ,  A61K45/06 ,  A61K38/57

Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

Abstract translation: 改良的Ac-TMP-2蛋白缺乏通常存在于全长或野生型Ac-TMP-2蛋白质中的一个或多个酸性C末端氨基酸，并且也可能缺少一个或多个N-末端氨基 酸，同时保留N-末端或其附近的氨基酸序列C-S-C。 修饰的Ac-TMP-2蛋白可用于减少或减轻受试者的炎症的方法和组合物。 炎症可能与疾病相关，是消化道疾病，如慢性胃炎或炎症性肠病如克罗恩病或溃疡性结肠炎，或呼吸系统疾病，如哮喘，肺气肿，慢性支气管炎和慢性疾病 阻塞性肺疾病。

公开(公告)号：US08883517B2

公开(公告)日：2014-11-11

申请号：US13395723

申请日：2010-09-14

Applicant: Neil James Cook

Inventor： Neil James Cook

IPC: G01N33/559 ,  G01N33/564 ,  G01N33/561

CPC classification number: G01N33/564 ,  G01N33/561

Abstract: The present invention relates to a method of detecting a target antibody, particularly a target autoantibody, in a sample, using a small molecule fluorophore-labelled target antigen, or a functional fragment, functional variant or functional derivative thereof that specifically binds to the target antibody. Detection is typically carried out using immunodiffusion or immunoelectrophoresis. The invention also relates to methods of diagnosing disease, particularly autoimmune disease, using small molecule fluorophore labelled target antigens and autoantigens. Small molecule fluorophore labelled target antigens, including autoantigens, are also disclosed, as are uses such.

Abstract translation: 本发明涉及使用特异性结合靶抗体的小分子荧光团标记的靶抗原或其功能性片段，功能性变体或功能性衍生物来检测样品中的靶抗体，特别是靶自身抗体的方法 。 检测通常使用免疫扩散或免疫电泳进行。 本发明还涉及使用小分子荧光团标记的靶抗原和自身抗原来诊断疾病，特别是自身免疫性疾病的方法。 还公开了小分子荧光团标记的靶抗原，包括自身抗原，以及其用途。

公开(公告)号：US08501438B2

公开(公告)日：2013-08-06

申请号：US13484665

申请日：2012-05-31

Applicant: Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

Inventor： Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

IPC: C12P21/06 ,  C12N1/15 ,  C12N1/19 ,  A01N43/78 ,  C07D277/26

CPC classification number: C07K16/32 ,  C07K2317/41 ,  C12P21/005

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.

Abstract translation: 描述了一种用于生产具有减少量的O-连接糖基化的蛋白质组合物的方法。 该方法包括在存在Pmt介导的O-连接糖基化抑制剂和/或在一种或多种α-1,2-甘露糖苷酶存在下培养的细胞中产生蛋白质。

公开(公告)号：US20120322101A1

公开(公告)日：2012-12-20

申请号：US13530768

申请日：2012-06-22

Applicant: Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

Inventor： Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

IPC: C12P21/00

CPC classification number: C07K16/32 ,  C07K2317/41 ,  C12P21/005

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.

Abstract translation: 描述了一种用于生产具有减少量的O-连接糖基化的蛋白质组合物的方法。 该方法包括在存在Pmt介导的O-连接糖基化的抑制剂和/或在一种或多种α-1,2-甘露糖苷酶的存在下培养的细胞中产生蛋白质。

公开(公告)号：US20120279262A1

公开(公告)日：2012-11-08

申请号：US13549716

申请日：2012-07-16

Applicant: JENN-YEU NIEH ,  BENNETT JAMES COOK ,  JAMES ANDREW OSKINS

Inventor： JENN-YEU NIEH ,  BENNETT JAMES COOK ,  JAMES ANDREW OSKINS

IPC: D06F33/02

CPC classification number: D06F33/02 ,  D06F39/087 ,  D06F2202/085 ,  D06F2204/086

Abstract: A method for determining the laundry load size according to one embodiment of the invention in an automatic clothes washer comprising supplying water to a reference water level to define a first amount of water, supplying water from the reference water level to a second water level above the reference water level and sufficient to submerge the laundry load to define a second amount of water, and determining a load size for the laundry load based on the second amount of water such that errors associated with the first amount of water are not considered in the load size determination based on the second amount of water.

Abstract translation: 一种用于在自动洗衣机中根据本发明的一个实施例确定衣物负载大小的方法，包括向参考水位供水以限定第一量的水，将水从参考水位供应到第二水位以上 参考水位并足以淹没衣物负载以限定第二量的水，并且基于第二量的水确定衣物负载的负载大小，使得在负载中不考虑与第一量的水相关的误差 基于第二量的水的尺寸测定。

公开(公告)号：US20100317619A1

公开(公告)日：2010-12-16

申请号：US12779449

申请日：2010-05-13

Applicant: James Cook ,  Shengming Huang ,  Rahul Edwankar ,  Ojas A. Namjoshi ,  Zhi-Jian Wang

Inventor： James Cook ,  Shengming Huang ,  Rahul Edwankar ,  Ojas A. Namjoshi ,  Zhi-Jian Wang

IPC: A61K31/695 ,  A61K31/5517 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/04 ,  A61P25/06

CPC classification number: C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D471/04 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

Abstract: In preferred embodiments, the present invention provides methods of treatment and pharmaceutical compositions for the suppression, alleviation and prevention of the often chronic, severe and debilitating pain that can accompany inflammatory diseases and neuropathic insults, pain that is often unresponsive to conventional analgesic treatment. The preferred embodiments of the present invention further relate to methods of treatment and pharmaceutical compositions using benzodiazepine derivatives that provide suppression, alleviation and prevention of neuropathic pain, migraine-related pain and inflammatory pain with reduced sedative and ataxic side effects.

Abstract translation: 在优选的实施方案中，本发明提供治疗方法和用于抑制，缓解和预防常伴有炎性疾病和神经性损伤的常规慢性，严重和衰弱性疼痛的药物组合物，其通常对常规镇痛治疗无反应。 本发明的优选实施方案还涉及使用苯并二氮杂衍生物的治疗方法和药物组合物，其提供抑制，缓解和预防神经性疼痛，偏头痛相关疼痛和炎症性疼痛，同时具有降低的镇静和共济失调副作用。

公开(公告)号：US20100187382A1

公开(公告)日：2010-07-29

申请号：US12360211

申请日：2009-01-27

Applicant: Arnold James Cook

Inventor： Arnold James Cook

IPC: F16M11/20

CPC classification number: A63B71/0036 ,  A47G25/0664 ,  A47G25/0671 ,  A63B21/0605 ,  A63B21/065

Abstract: A novel apparatus for storing weighted garments is disclosed wherein the weighted garment is slid down onto the inner support system of the weighted garment support system such that the weighted garment is supported and balanced above the ground. The apparatus includes an inner support system that supports the weighted garment from inside and below the weighted garment. The apparatus includes different inner support system designs to hold different types of weighted garments including: weighted vests, weighted shirts, weighted pants, wrist weights, ankle weights and wearable hand weights. The apparatus also includes a support base that can hold one or more inner support systems and the base can be stationary or mobile. An apparatus is also disclosed that supports the weighted garments from the side through a hole in the weighted garment. In addition a method for positioning the weighted garment on the weighted garment support system is disclosed along with a method for washing and drying the weighted garment while the weighted garment rests on the weighted garment support system.

Abstract translation: 公开了一种用于存储加重服装的新颖设备，其中加重衣服向下滑动到加重衣服支撑系统的内部支撑系统上，使得加重的服装在地面上方被支撑和平衡。 该装置包括一个内部支撑系统，该内部支撑系统从加重的衣服的内部和下面支撑加权的衣服。 该装置包括不同的内部支撑系统设计，以容纳不同类型的加重服装，包括：加重背心，加重衬衫，加重裤子，腕重，脚踝重量和可穿戴手重。 该装置还包括支撑基座，其可以容纳一个或多个内部支撑系统，并且基座可以是静止的或移动的。 还公开了一种装置，其从侧面通过加重服装中的孔支撑加重服装。 此外，还公开了一种用于将加重衣服定位在加权服装支撑系统上的方法，以及用于在加重服装搁置在加权服装支撑系统上时洗涤和干燥加重服装的方法。

公开(公告)号：US20100053330A1

公开(公告)日：2010-03-04

申请号：US12198678

申请日：2008-08-26

Applicant: Dean R. Hellickson ,  Kurt Holmquist ,  James Cook ,  Robert Burns ,  Andrew W. Guyette

Inventor： Dean R. Hellickson ,  Kurt Holmquist ,  James Cook ,  Robert Burns ,  Andrew W. Guyette

IPC: H04N7/18 ,  G06K9/00

CPC classification number: G01S17/023 ,  G01S7/4802 ,  G01S17/42 ,  G01S17/89 ,  G01S19/13 ,  G08B13/181 ,  G08B13/19645

Abstract: A security sensor system comprises one or more laser detection and ranging (LADAR) sensors configured for accumulation of three-dimensional image data. In one embodiment, the one or more LADAR sensors each comprise a LADAR device, such as a MEMS device, configured to transmit a plurality of laser pulses, and a microprocessor operatively coupled to the LADAR device. One or more data storage devices is operatively coupled to the microprocessor and configured to store the three-dimensional image data, as well as predetermined protected area boundary and fixed object definitions. A GPS receiver can be operatively coupled to the microprocessor and a GPS antenna. The microprocessor is configured to perform a LADAR image analysis that compares the three-dimensional image data with the protected area boundary and fixed object definitions to identify one or more potential intruders.

Abstract translation: 安全传感器系统包括被配置用于累积三维图像数据的一个或多个激光检测和测距（LADAR）传感器。 在一个实施例中，一个或多个LADAR传感器各自包括被配置为传输多个激光脉冲的LADAR装置，诸如MEMS装置，以及可操作地耦合到LADAR装置的微处理器。 一个或多个数据存储设备可操作地耦合到微处理器并被配置为存储三维图像数据以及预定的保护区域边界和固定对象定义。 GPS接收机可以可操作地耦合到微处理器和GPS天线。 微处理器被配置为执行将三维图像数据与保护区边界和固定对象定义进行比较的LADAR图像分析，以识别一个或多个潜在入侵者。