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    High-throughput apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
    3.
    发明授权
    High-throughput apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures 失效
    用于识别，定量和测定混合物中化合物的纯度的高通量仪器

    公开(公告)号：US6090280A

    公开(公告)日：2000-07-18

    申请号：US294168

    申请日：1999-04-19

    申请人： James A. Connelly ,  Linda O'Brien ,  Sue Xiuqing Zhang ,  Ning Zhao

    发明人： James A. Connelly ,  Linda O'Brien ,  Sue Xiuqing Zhang ,  Ning Zhao

    IPC分类号： G01N30/72 ,  G01N30/74 ,  G01N30/78 ,  G01N30/82 ,  G01N30/86 ,  G01N35/00 ,  G01N35/08 ,  B01D15/08

    CPC分类号： G01N30/82 ,  G01N30/8679 ,  B01J2219/00707 ,  G01N30/72 ,  G01N30/78 ,  G01N30/8631 ,  G01N35/08

    摘要： A method and apparatus for high-throughput identity confirmation, quantitation and purity determination of a compound of interest in a mixture of compounds is disclosed. According to the method, a chemical mixture, such as may be obtained from a chemical library, is processed to obtain a stream having a time-varying composition, such as by using a high pressure liquid chromatograph. The stream is split into two portions or streams for substantially contemporaneous detection in a compound-identifying device, such as a mass spectrograph, and in a compound-quantitating device, such as an evaporative light scattering detector. A peak in a chromatogram obtained from the compound-quantitating device is identified as the compound of interest by cross-correlation, via elution time, with chromatographic results obtained from the compound-identifying device. Once the peak is identified as corresponding to the compound of interest, the corresponding peak area is used for quantitation and purity determination.

    摘要翻译： 公开了一种用于化合物混合物中感兴趣的化合物的高通量身份确认，定量和纯度测定的方法和装置。 根据该方法，可以从化学文库获得化学混合物，例如通过使用高压液相色谱仪，得到具有时变组成的流。 在化合物识别装置（例如质谱仪）和化合物定量装置（例如蒸发光散射检测器）中，该流被分成两部分或物流，用于基本同时检测。 从化合物定量装置获得的色谱图中的峰通过相互相关，通过洗脱时间，由化合物识别装置获得的色谱结果鉴定为感兴趣的化合物。 一旦峰被鉴定为与感兴趣的化合物相对应，则相应的峰面积用于定量和纯度测定。

    High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
    4.
    发明授权
    High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures 失效
    用于鉴定，定量和测定混合物中化合物的纯度的高通量方法和装置

    公开(公告)号：US5938932A

    公开(公告)日：1999-08-17

    申请号：US970941

    申请日：1997-11-14

    申请人： James A. Connelly ,  Linda O'Brien ,  Sue Xiuqing Zhang ,  Ning Zhao

    发明人： James A. Connelly ,  Linda O'Brien ,  Sue Xiuqing Zhang ,  Ning Zhao

    IPC分类号： G01N30/72 ,  G01N30/74 ,  G01N30/78 ,  G01N30/82 ,  G01N30/86 ,  G01N35/00 ,  G01N35/08 ,  B01D15/08

    CPC分类号： G01N30/82 ,  G01N30/8679 ,  B01J2219/00707 ,  G01N30/72 ,  G01N30/78 ,  G01N30/8631 ,  G01N35/08

    摘要： A method and apparatus for high-throughput identity confirmation, quantitation and purity determination of a compound of interest in a mixture of compounds is disclosed. According to the method, a chemical mixture, such as may be obtained from a chemical library, is processed to obtain a stream having a time-varying composition, such as by using a high pressure liquid chromatograph. The stream is split into two portions or streams for substantially contemporaneous detection in a compound-identifying device, such as a mass spectrograph, and in a compound-quantitating device, such as an evaporative light scattering detector. A peak in a chromatogram obtained from the compound-quantitating device is identified as the compound of interest by cross-correlation, via elution time, with chromatographic results obtained from the compound-identifying device. Once the peak is identified as corresponding to the compound of interest, the corresponding peak area is used for quantitation and purity determination.

    摘要翻译： 公开了一种用于化合物混合物中感兴趣的化合物的高通量身份确认，定量和纯度测定的方法和装置。 根据该方法，可以从化学文库获得化学混合物，例如通过使用高压液相色谱仪，得到具有时变组成的流。 在化合物识别装置（例如质谱仪）和化合物定量装置（例如蒸发光散射检测器）中，该流被分成两部分或物流，用于基本同时检测。 从化合物定量装置获得的色谱图中的峰通过相互相关，通过洗脱时间，由化合物识别装置获得的色谱结果鉴定为感兴趣的化合物。 一旦峰被鉴定为与感兴趣的化合物相对应，则相应的峰面积用于定量和纯度测定。