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    Stimulus Sensitive Magnetic Nanocomposite Using Pyrene Polymer, and Contrast Medium Composition Containing the Nanocomposite
    3.
    发明申请
    Stimulus Sensitive Magnetic Nanocomposite Using Pyrene Polymer, and Contrast Medium Composition Containing the Nanocomposite 审中-公开
    使用芘聚合物的激发敏感磁性纳米复合材料和包含纳米复合材料的对比介质组成

    公开(公告)号：US20130183249A1

    公开(公告)日：2013-07-18

    申请号：US13812631

    申请日：2010-12-27

    申请人： Seung Joo Haam ,  Jin Suck Suh ,  Yong Min Huh ,  Jae Moon Yang ,  Eun Kyung Lim

    发明人： Seung Joo Haam ,  Jin Suck Suh ,  Yong Min Huh ,  Jae Moon Yang ,  Eun Kyung Lim

    IPC分类号： A61K49/18 ,  A61K39/44

    CPC分类号： A61K49/1824 ,  A61K39/44 ,  A61K47/6923 ,  A61K49/1839 ,  A61K49/186

    摘要： Provided are a stimuli-sensitive magnetic nanocomposite using a pyrene-conjugated polymer and a method of preparing the same. Particularly, the stimuli-sensitive magnetic nanocomposite includes magnetic nanoparticles, an amphiphilic compound including at least one hydrophobic domain having a material having a pyrene structure and at least one hydrophilic domain and a pharmaceutically active ingredient. Here, the amphiphilic compound surrounds the pharmaceutically active ingredient, and the pharmaceutically active ingredient surrounds the magnetic nanoparticle and is chemically bound to a hydrophobic domain. Accordingly, the magnetic nanoparticles and the pharmaceutically active ingredient are stable in an aqueous solution, have excellent magnetic properties and a rapid drug release behavior due to a specific stimulus, and exhibit targeting according to a tissue-specific binding component. Thus, the stimuli-sensitive magnetic nanocomposite has target specificity and serves as a contrast composition or pharmaceutical composition.

    摘要翻译： 提供使用芘共轭聚合物的刺激敏感性磁性纳米复合物及其制备方法。 特别地，刺激敏感性磁性纳米复合材料包括磁性纳米颗粒，两亲化合物，其包括至少一个具有芘结构的材料和至少一个亲水结构域的药物活性成分的疏水结构域。 这里，两亲性化合物包围药物活性成分，并且药物活性成分包围磁性纳米颗粒并与化学结合到疏水结构域。 因此，磁性纳米颗粒和药物活性成分在水溶液中是稳定的，具有优异的磁性和由特定刺激引起的快速药物释放行为，并且根据组织特异性结合组分显示靶向。 因此，刺激敏感的磁性纳米复合材料具有靶特异性，并且用作造影剂组合物或药物组合物。