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1.发明申请Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections 审中-公开某些包含双环化学物质的氮气用于治疗病毒感染公开(公告)号：US20100204265A1
公开(公告)日：2010-08-12
申请号：US12368249
申请日：2009-02-09
Applicant: Subramanian Baskaran , Jack Maung , Martin Leon Neitzel , Roopa Rai , Irina Slododov , Vincent W-F Tai
Inventor： Subramanian Baskaran , Jack Maung , Martin Leon Neitzel , Roopa Rai , Irina Slododov , Vincent W-F Tai
IPC: A61K31/437 , C07D471/04 , A61P31/12
CPC classification number: C07D471/04
Abstract: Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
Abstract translation: 提供某些化学实体，药物组合物和治疗黄病毒属病毒家族（例如肝炎病毒（丙型肝炎或HCV））的方法。
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公开(公告)号：US09187459B2
公开(公告)日：2015-11-17
申请号：US14118200
申请日：2012-05-17
Applicant: Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
Inventor： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
IPC: A01N43/54 , A61K31/517 , C07D401/00 , C07D239/72 , C07D405/12 , C07D493/04
CPC classification number: C07D405/12 , C07D493/04
Abstract: The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.
Abstract translation: 本发明提供了喹唑啉-7-醚衍生物，特别是作为受体蛋白酪氨酸激酶（RTK）抑制剂的4-苯乙烯基-6-丁烯酰氨基 - 喹唑啉-7-醚衍生物。 所述化合物可用于治疗涉及RTK活性的疾病和病症，例如过度增殖性疾病（例如癌症）。 还提供了制备喹唑啉衍生物的方法和单独使用或作为药物组合用作治疗剂的方法。
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3.发明申请Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections 审中-公开某些包含双环化学物质的氮气用于治疗病毒感染公开(公告)号：US20120121540A1
公开(公告)日：2012-05-17
申请号：US12672942
申请日：2008-08-08
Applicant: Franz Ulrich Schmitz , Vincent W.F Tai , Roopa Ral , Christopher Don Roberts , Ali Dehghani Mohammad Abadi , Subramanian Baskaran , Irina Slobodov , Jack Maung , Martin Leon Neitzel
Inventor： Franz Ulrich Schmitz , Vincent W.F Tai , Roopa Ral , Christopher Don Roberts , Ali Dehghani Mohammad Abadi , Subramanian Baskaran , Irina Slobodov , Jack Maung , Martin Leon Neitzel
IPC: A61K31/437 , C07D409/12 , A61K31/404 , C07D409/14 , A61K31/5377 , C07D519/00 , C07D487/04 , A61K31/5025 , A61K31/496 , A61K31/506 , A61K31/497 , C07D453/04 , A61K31/46 , A61K38/21 , A61K31/444 , C07D405/10 , A61K31/4184 , C07D405/14 , A61K31/4545 , C07D471/04
CPC classification number: C07D471/04 , C07D487/04
Abstract: Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
Abstract translation: 提供某些化学实体，药物组合物和治疗黄病毒属病毒家族（例如肝炎病毒（丙型肝炎或HCV））的方法。
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公开(公告)号：US20180111923A1
公开(公告)日：2018-04-26
申请号：US15793770
申请日：2017-10-25
Applicant: Hui Li , Thilo Heckrodt , Yan Chen , Ryan Kelley , Darren McMurtrie , Kin Tso , Vanessa Taylor , Rajinder Singh , Rose Yen , Jack Maung
Inventor： Hui Li , Thilo Heckrodt , Yan Chen , Ryan Kelley , Darren McMurtrie , Kin Tso , Vanessa Taylor , Rajinder Singh , Rose Yen , Jack Maung
IPC: C07D413/14
CPC classification number: C07D413/14 , A61P29/00
Abstract: Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
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Patent Agency Ranking
公开(公告)号：US20140221406A1
公开(公告)日：2014-08-07
申请号：US14118200
申请日：2012-05-17
Applicant: Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
Inventor： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
IPC: C07D405/12 , C07D493/04
CPC classification number: C07D405/12 , C07D493/04
Abstract: The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.
Abstract translation: 本发明提供了喹唑啉-7-醚衍生物，特别是作为受体蛋白酪氨酸激酶（RTK）抑制剂的4-苯乙烯基-6-丁烯酰氨基 - 喹唑啉-7-醚衍生物。 所述化合物可用于治疗涉及RTK活性的疾病和病症，例如过度增殖性疾病（例如癌症）。 还提供了制备喹唑啉衍生物的方法和单独使用或作为药物组合用作治疗剂的方法。
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6.发明申请Certain nitrogen containing bicyclic chemical entities for treating viral infections 审中-公开某些含氮双环化学实体用于治疗病毒感染公开(公告)号：US20090176778A1
公开(公告)日：2009-07-09
申请号：US12228139
申请日：2008-08-08
Applicant: Franz Ulrich Schmitz , Vincent W-F Tai , Roopa Rai , Christopher Don Roberts , Ali Dehghani Mohammad Abadi , Subramanian Baskaran , Irina Slobodov , Jack Maung , Martin Leon Neitzel
Inventor： Franz Ulrich Schmitz , Vincent W-F Tai , Roopa Rai , Christopher Don Roberts , Ali Dehghani Mohammad Abadi , Subramanian Baskaran , Irina Slobodov , Jack Maung , Martin Leon Neitzel
IPC: A61K31/5377 , C07D471/04 , A61K31/437 , A61P31/12
CPC classification number: C07D471/04 , C07D487/04
Abstract: Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
Abstract translation: 提供某些化学实体，药物组合物和治疗黄病毒属病毒家族（例如肝炎病毒（丙型肝炎或HCV））的方法。
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公开(公告)号：US09090588B2
公开(公告)日：2015-07-28
申请号：US14002983
申请日：2012-03-02
Applicant: Wang Shen , Aimin Zhang , Jack Maung , Xiaoling Zheng
Inventor： Wang Shen , Aimin Zhang , Jack Maung , Xiaoling Zheng
IPC: C07D405/06 , A61K31/517
CPC classification number: C07D405/06 , A61K31/517
Abstract: The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).
Abstract translation: 本发明提供炔取代的喹唑啉化合物，例如不可逆ErbB激酶抑制剂的式（I）化合物。 所述化合物可用于治疗涉及ErbB激酶活性的疾病和病症，例如过度增殖性疾病（例如癌症）。
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公开(公告)号：US20140128417A1
公开(公告)日：2014-05-08
申请号：US14002983
申请日：2012-03-02
Applicant: Wang Shen , Aimin Zhang , Jack Maung , Xiaoling Zheng
Inventor： Wang Shen , Aimin Zhang , Jack Maung , Xiaoling Zheng
IPC: C07D405/06
CPC classification number: C07D405/06 , A61K31/517
Abstract: The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).
Abstract translation: 本发明提供炔取代的喹唑啉化合物，例如不可逆ErbB激酶抑制剂的式（I）化合物。 所述化合物可用于治疗涉及ErbB激酶活性的疾病和病症，例如过度增殖性疾病（例如癌症）。
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公开(公告)号：US20100272680A1
公开(公告)日：2010-10-28
申请号：US12702702
申请日：2010-02-09
Applicant: Subramanian Baskaran , Jack Maung , Martin Neitzel , Rai Roopa , Christopher Roberts , Vincent Tai
Inventor： Subramanian Baskaran , Jack Maung , Martin Neitzel , Rai Roopa , Christopher Roberts , Vincent Tai
IPC: A61K38/21 , C07D471/04 , A61K31/437 , A61P31/12 , A61P31/14
CPC classification number: C07D471/04
Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).
Abstract translation: 提供式（I）的化合物及其药学上可接受的盐，其药物组合物，其制备方法及其用于治疗由病毒如丙型肝炎病毒（HCV）的黄病毒科家族介导的病毒感染的用途。
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