公开(公告)号：US07312194B2

公开(公告)日：2007-12-25

申请号：US10676436

申请日：2003-06-30

Applicant: Istvan Toth ,  Robert Falconer ,  Shaun Emmanuel De Cruz ,  Ross Peter McGeary ,  Benjamin Paul Ross

Inventor： Istvan Toth ,  Robert Falconer ,  Shaun Emmanuel De Cruz ,  Ross Peter McGeary ,  Benjamin Paul Ross

IPC: A61H38/14 ,  A61K38/16 ,  A61K31/715

CPC classification number: C07H5/06 ,  A61K47/54 ,  C07H13/04

Abstract: The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical agents comprising these carriers. The compounds of the invention comprise a mono- or oligosaccharide, a lipidic moiety, and optionally a linker and/or a spacer. The pharmaceutical agents of the invention are particularly useful for oral administration.

Abstract translation: 本发明涉及可用于递送各种治疗有用分子的化合物。 特别地，本发明涉及能够作为治疗有用分子的载体的化合物以及包含这些载体的药剂。 本发明的化合物包含单糖或寡糖，脂质部分和任选的连接体和/或间隔基。 本发明的药剂对于口服给药是特别有用的。

公开(公告)号：US5035113A

公开(公告)日：1991-07-30

申请号：US297669

申请日：1989-01-13

Applicant: Sandor Simonyi ,  Laszlo Torocsik ,  Istvan Toth ,  Gyorgy Valoczi

Inventor： Sandor Simonyi ,  Laszlo Torocsik ,  Istvan Toth ,  Gyorgy Valoczi

IPC: F16H59/04 ,  F16H61/04 ,  F16H61/24 ,  F16H61/28 ,  F16H61/30 ,  F16H61/684 ,  F16H63/30

CPC classification number: F16H59/044 ,  F16H61/2807 ,  F16H63/3023 ,  F16H2061/2823 ,  F16H2061/307 ,  F16H61/0403 ,  F16H61/24 ,  F16H61/30 ,  F16H61/684 ,  Y10T74/19251 ,  Y10T74/20024 ,  Y10T74/2003

Abstract: A remote control shifting system for a mechanical transmission. The transmission is operated by two pneumatic cylinders, a selecting cylinder operating in the direction of shift path selection and a shifting cylinder acting in the direction of shifting. The shifting cylinder operates with two force stages, a lower force for effecting synchronization of gears about to be engaged, and a higher force level for actually engaging or disengaging the selected gears. A remote shift control unit is designed to closely emulate the action of a direct-operating manual shift level. During the synchronizing phase, the shift lever moves easily in the shifting direction. After a preliminary movement, however, further movement is allowed only against considerable resistance, as if conventionally mechanically forcing gears into meshing engagement. After the remotely driven shift operation actually takes place, the shift level resistance is momentarily released, allowing the lever to be fully seated in its shift position, after which the lever is held in the shifted position, allowing movement out of shifted position only under applied resistance. The timing and feel of the system closely approximate that of a conventional, direct-actuation mechanical transmission.

Abstract translation: 用于机械传动的遥控换档系统。 变速器由两个气动缸操作，选择缸在换档路径选择的方向上工作，变速缸沿变速方向作用。 换档气缸以两个力级操作，用于实现齿轮接合同步的较小力，以及用于实际接合或分离选定齿轮的较高力级。 远程变速控制单元被设计为紧密地模拟直接操作手动变速级的动作。 在同步阶段，变速杆在换档方向上容易移动。 然而，在初步运动之后，仅允许进一步的运动抵抗相当大的阻力，就好像通常机械地迫使齿轮啮合。 在远程驾驶变速操作实际发生之后，变速级别电阻瞬间释放，允许杠杆完全就位在其换档位置，之后杠杆保持在移动位置，允许仅在施加位置移动移出位置 抵抗性。 系统的时间和感觉与传统的直接致动机械传动的时机和感觉紧密相近。

公开(公告)号：US4896565A

公开(公告)日：1990-01-30

申请号：US187497

申请日：1988-04-28

Applicant: Sandor Simonyi ,  Laszlo Torocsik ,  Istvan Toth ,  Gyorgy Valoczi

Inventor： Sandor Simonyi ,  Laszlo Torocsik ,  Istvan Toth ,  Gyorgy Valoczi

IPC: B60K20/00 ,  F16H59/36 ,  F16H59/40 ,  F16H59/42 ,  F16H59/44 ,  F16H59/46 ,  F16H61/02

CPC classification number: F16H61/0213 ,  F16H2059/467 ,  F16H59/36 ,  F16H59/40 ,  F16H59/42 ,  F16H59/44 ,  Y10S477/901 ,  Y10S477/902 ,  Y10S477/904 ,  Y10T477/6347 ,  Y10T477/635 ,  Y10T477/69 ,  Y10T477/692

Abstract: A process for controlling an automatic transmission wherein engine speed and output speed are measured and the slip conditions are derived therefrom. When conditions of downshift occur, as determined by excessively high slip and/or excessively low speed, the conditions existing at the moment of downshift are evaluated, and a comparative slip signal is derived and saved. This signal is employed as reference relating to the momentary slip conditions of the vehicle for use in determining the proper moment for a subsequent upshift. Thus, conditions for an upshift, following a particular downshift, are modified as a function of the circumstances requiring the downshift (e.g. normal deceleration, overtaking another vehicle, ascending a hill). Procedures are also included for enabling engagement of a friction clutch, for bypassing the torque converter of the transmission, under certain conditions in advance of an upshift.

Abstract translation: 一种用于控制自动变速器的过程，其中测量发动机速度和输出速度并从中获得滑动条件。 当由于过高的滑差和/或过低的速度所产生的降挡条件发生时，评估在降档时存在的条件，得到并保存比较滑差信号。 该信号被用作关于用于确定随后的升档的适当时刻的车辆的瞬时滑动条件的参考。 因此，根据需要降档的情况（例如正常减速，超越另一车辆，爬山），特定降档之后的升挡条件被修改。 还包括用于在升档前的特定条件下使摩擦离合器接合以便绕过变速器的变矩器的步骤。

公开(公告)号：US4889944A

公开(公告)日：1989-12-26

申请号：US126218

申请日：1987-11-25

Applicant: Karoly Balogh ,  Zsolt Dombay ,  Karoly Fodor ,  Erzebet Grega nee Toth ,  Erno Lorik ,  Magdolna Magyar nee Tomorkenyi ,  Jozsef Nagy ,  Karoly Pasztor ,  Pal Santha ,  Gyula Tarpai ,  Istvan Toth ,  Eszter Urszin nee Simon

Inventor： Karoly Balogh ,  Zsolt Dombay ,  Karoly Fodor ,  Erzebet Grega nee Toth ,  Erno Lorik ,  Magdolna Magyar nee Tomorkenyi ,  Jozsef Nagy ,  Karoly Pasztor ,  Pal Santha ,  Gyula Tarpai ,  Istvan Toth ,  Eszter Urszin nee Simon

IPC: A01N57/26 ,  C07F9/24 ,  C07F9/553 ,  C07F9/564 ,  C07F9/572 ,  C07F9/58 ,  C07F9/59 ,  C07F9/6506 ,  C07F9/6521 ,  C07F9/653 ,  C07F9/6533

CPC classification number: C07F9/6533 ,  A01N57/26 ,  C07F9/2458 ,  C07F9/5532 ,  C07F9/564 ,  C07F9/572 ,  C07F9/58 ,  C07F9/59 ,  C07F9/65067 ,  C07F9/65217 ,  C07F9/653

Abstract: The present invention relates to novel compounds of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and stand for alkyl having 1 to 4 carbon atoms optionally substituted by one or more halogen atoms, alkenyl having 2 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, phenyl or lower alkoxy-alkyl group,R.sub.3 stands for alkyl having 1 to 6 carbon atoms or alkenyl having 2 to 6 carbont atoms,R.sub.4 and R.sub.5 are the same or different and represent hydrogen, alkyl having 1 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, phenyl, benzyl, phenyl substituted by one or more alkyl having 1 to 3 carbon atoms and/or by one or more halogen atoms, lower alkoxy-alkyl, a group of the formula --(CH.sub.2).sub.n --R.sub.6, wherein n is an integer between 0 to 3 and R.sub.6 stands for a 3 to 7 membered saturated or unsaturated ring comprising 1 to 3 heteroatoms, said heteroatoms can be selected from the group of nitrogen and/or oxygen and/or sulphur, and R.sub.4 and R.sub.5 can together form with the adjacent nitrogen atom a hexamethylene-imino group. The compounds of the invention exhibit acaricidal, insecticidal and fungicidal activity.

Abstract translation: 本发明涉及新的式（I）化合物，其中R 1和R 2相同或不同，代表任选被一个或多个卤素原子取代的具有1至4个碳原子的烷基，具有2个 至6个碳原子，具有3至6个碳原子的环烷基，苯基或低级烷氧基 - 烷基，R3代表具有1至6个碳原子的烷基或具有2至6个碳原子的烯基，R4和R5相同或不同，代表 氢，具有1至6个碳原子的烷基，具有2至6个碳原子的烯基，具有3至6个碳原子的环烷基，苯基，苄基，被一个或多个具有1至3个碳原子的烷基取代的苯基和/或一个或多个 卤素原子，低级烷氧基 - 烷基，式 - （CH 2）n -R 6的基团，其中n是0至3之间的整数，R 6表示包含1至3个杂原子的3至7元饱和或不饱和的环，所述 杂原子可以选自氮和/或氧和/或硫，R4a nd R5可以与相邻的氮原子一起形成六亚甲基亚氨基。 本发明的化合物显示出杀螨，杀虫和杀真菌活性。

公开(公告)号：US4623383A

公开(公告)日：1986-11-18

申请号：US633382

申请日：1984-07-23

Applicant: Erzsebet Grega nee Toth ,  Jozsef Nagy ,  Gyula Tarpai ,  Erno Lorik ,  Istvan Toth ,  Karoly Pasztor ,  Zsuzsanna Bartfai nee Harsanyi ,  Ilona Beres ,  Laszlo Tasi ,  Eszter Urszin nee Simon ,  Zsolt Dombay ,  Judit Bajusz nee Olah ,  Karoly Balogh

Inventor： Erzsebet Grega nee Toth ,  Jozsef Nagy ,  Gyula Tarpai ,  Erno Lorik ,  Istvan Toth ,  Karoly Pasztor ,  Zsuzsanna Bartfai nee Harsanyi ,  Ilona Beres ,  Laszlo Tasi ,  Eszter Urszin nee Simon ,  Zsolt Dombay ,  Judit Bajusz nee Olah ,  Karoly Balogh

IPC: C07C237/06 ,  A01N25/32 ,  A01N37/18 ,  A01P13/00 ,  C07C235/74 ,  C07C237/22 ,  C07C103/50 ,  A01N37/22 ,  A01N43/46 ,  A01N47/12

CPC classification number: C07C237/22 ,  A01N25/32

Abstract: The present invention relates to novel N- and optionally N'-substituted (N-dichloroacetyl)glycine amides of the formula I with antidote action, to antidote compositions containing such compounds, to selective herbicide compositions containing these antidotes together with herbicidally active compounds and to a method for treating cultivated plants with said compositions.

Abstract translation: 本发明涉及具有解毒作用的式I的新型N-和任选的N-取代的（N-二氯乙酰基）甘氨酸酰胺，含有这些化合物的解毒剂组合物，含有这些解毒剂和除草活性化合物的选择性除草剂组合物，以及 用所述组合物处理栽培植物的方法。

公开(公告)号：US4613461A

公开(公告)日：1986-09-23

申请号：US687608

申请日：1984-12-31

Applicant: Peter Viski ,  Laszlo Simandi ,  Ferenc Nagy ,  Gabor Besenyei ,  Gyorgy Paszthy ,  Gyula Pazmandi ,  Istvan Szita ,  Gyula Szilagyi ,  Istvan Toth ,  Ilona Szigeti nee Kiss

Inventor： Peter Viski ,  Laszlo Simandi ,  Ferenc Nagy ,  Gabor Besenyei ,  Gyorgy Paszthy ,  Gyula Pazmandi ,  Istvan Szita ,  Gyula Szilagyi ,  Istvan Toth ,  Ilona Szigeti nee Kiss

IPC: C07C333/02 ,  C07D211/60 ,  C07C153/00 ,  C07C154/00 ,  C07D207/00

CPC classification number: C07C333/02

Abstract: The invention relates to a new process for preparing known thiolcarbamate esters of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 stand independently for hydrogen or a straight or branched chain alkyl group containing 1 to 6 carbon atoms or an alkenyl group containing 2 to 6 atoms, or an alkyl group containing 1 to 6 or an alkenyl group containing 2 to 6 carbon atoms and mono- or polysubstituted by halogen, oxygen, sulphur and/or nitrogen; orR.sup.1 and R.sup.2 together may represent an optionally substituted .alpha.,.omega.-alkylene group containing 4 to 6 carbon atoms;R.sup.3 and R.sup.4 stand independently for hydrogen or an alkyl group containing 1 to 4 carbon atoms and optionally substituted by halogen or by a group containing oxygen, sulphur and/or nitrogen; andR.sup.5 and R.sup.6 both stand for hydrogen; orR.sup.5 and R.sup.6 together may represent a chemical bond.The compounds of general formula (I) are prepared by reacting(a) thiolcarbamate salts of the general formula (II) ##STR2## wherein the meanings of R.sup.1 and R.sup.2 are as defined above, andY stands for a primary, secondary or tertiary ammonium ion or an alkaline metal ion; or(b) amines of the general formula (III) ##STR3## wherein the meanings of R.sup.1 and R.sup.2 are as defined above, together with sulphur and carbon monoxide; or(c) amine of the general formula (III) together with carbonyl sulphidewith alkynes of the general formula (IV)R.sup.3 --C.tbd.C--R.sup.4 (IV)wherein the meanings of R.sup.3 and R.sup.4 are as defined above and, if desired, hydrogenating the obtained product of general formula (I), wherein the meanings of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above and R.sup.5 together with R.sup.6 forms a chemical bond, to a compound of the general formula (I), wherein both R.sup.5 and R.sup.6 stand for hydrogen.

Abstract translation: 本发明涉及一种制备通式（I）的已知硫代氨基甲酸酯的新方法，其中R1和R2独立地表示氢或含有1至6个碳原子的直链或支链烷基或烯基 含有2至6个原子的基团，或含有1至6个的烷基或含2至6个碳原子的烯基，被卤素，氧，硫和/或氮单取代或多取代; 或者R 1和R 2一起可以表示任选取代的含有4至6个碳原子的α，ω-亚烷基; R3和R4分别独立地表示氢或含有1至4个碳原子的烷基，并且任选被卤素取代或被含氧，硫和/或氮的基团取代; R5和R6均代表氢; 或R5和R6一起可以表示化学键。 通式（I）的化合物是通过使（a）通式（II）的硫代氨基甲酸盐与其中R 1和R 2的含义如上所定义的通式（Ⅱ）的化合物反应，Y代表伯，仲 或叔铵离子或碱金属离子; 或（b）通式（III）的胺其中R 1和R 2的含义如上所定义，连同硫和一氧化碳; 或（c）通式（III）的胺与羰基硫化物与通式（IV）的炔类反应，其中R3和R4的含义如上所定义，如果需要， 氢化得到的通式（I）的产物，其中R 1，R 2，R 3和R 4的含义如上所定义，R 5与R 6一起形成化学键，通式（I）的化合物，其中两者 R5和R6代表氢。

公开(公告)号：US4554252A

公开(公告)日：1985-11-19

申请号：US449071

申请日：1982-12-13

Applicant: Tibor Farkas ,  Laszlo Vigh ,  Ibolya Horvath ,  Aniko Nagy nee Vanicsek ,  Ferenc Foglein ,  Annamaria Meszaros ,  Istvan Toth

Inventor： Tibor Farkas ,  Laszlo Vigh ,  Ibolya Horvath ,  Aniko Nagy nee Vanicsek ,  Ferenc Foglein ,  Annamaria Meszaros ,  Istvan Toth

IPC: A01G7/06 ,  A01H3/00 ,  A01H4/00 ,  A01N37/18 ,  A01N43/46 ,  C12N5/00 ,  C12N5/04

CPC classification number: C12N5/0025

Abstract: Disclosed is a process for improving the efficiency of in vitro propagation and tissue cultivating by tissue culture of cultivated of plants which comprises treating the plants during micropropagation and/or subsequent planting with an aqueous solution of one or a mixture of substituted amides or one or a mixture of substituted diamides.

Abstract translation: 公开了一种通过植物培养的组织培养来提高体外繁殖和组织培养的效率的方法，其包括在微繁殖和/或随后的种植过程中用一种或多种取代的酰胺或一种或多种 取代二酰胺的混合物。

公开(公告)号：US4493727A

公开(公告)日：1985-01-15

申请号：US438746

申请日：1982-11-03

Applicant: Istvan Toth ,  Jozsef Nagy ,  Zsolt Dombay ,  Erzsebet Grega nee Toth ,  Ibolya Horvath ,  Laszlo Vigh ,  Tibor Farkas

Inventor： Istvan Toth ,  Jozsef Nagy ,  Zsolt Dombay ,  Erzsebet Grega nee Toth ,  Ibolya Horvath ,  Laszlo Vigh ,  Tibor Farkas

IPC: A01N37/18 ,  A01N37/22 ,  A01N43/46 ,  C07D233/04

CPC classification number: A01N37/18 ,  A01N37/22 ,  A01N43/46

Abstract: The invention relates to a plant growth regulating composition which contains as active agent a compound of general formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can be identical or different and can stand for hydrogen, a C.sub.1-4 straight or branched alkyl group, cyclohexyl, phenyl, chlorophenyl, alkylphenyl, benzyl or alkylbenzyl group, or R.sub.1 and R.sub.2 can together with the N atoms form a heterocyclic ring.The growing of plants can be stimulated and the green weight can be increased to a significant degree by the treatment carried out with the composition of the invention.

Abstract translation: 本发明涉及一种植物生长调节组合物，其包含作为活性剂的通式（I）化合物其中R 1和R 2可以相同或不同，可代表氢，C 1-4直链或支链 烷基，环己基，苯基，氯苯基，烷基苯基，苄基或烷基苄基，或R 1和R 2可与N原子一起形成杂环。 可以刺激植物的生长，并且通过用本发明的组合物进行的处理可以显着提高绿色重量。

公开(公告)号：US4366129A

公开(公告)日：1982-12-28

申请号：US251997

申请日：1981-04-08

Applicant: Bela Czegledi ,  Mihaly Csovari ,  Miklos Erdelyi ,  Lajos Streker ,  Istvan Toth ,  Katalin Szabo nee Mogyorosi ,  Szilard Riederauer ,  Geza Szentgyorgyi

Inventor： Bela Czegledi ,  Mihaly Csovari ,  Miklos Erdelyi ,  Lajos Streker ,  Istvan Toth ,  Katalin Szabo nee Mogyorosi ,  Szilard Riederauer ,  Geza Szentgyorgyi

IPC: C01F7/22 ,  C01F7/26 ,  C01G49/00 ,  C01G49/06 ,  C21B15/00

CPC classification number: C01G49/06 ,  C01F7/26 ,  C01G49/0009 ,  C21B15/006 ,  C22B3/24 ,  C22B3/42 ,  Y02P10/234

Abstract: The invention concerns a process for the preparation of alumina and ferric oxide from low-grade aluminium and iron carriers. The processes, in addition to conventional technological steps, comprises the steps of dissolving the iron content of a ground, mineral material in an aqueous hydrochloric acid solution containing 200 to 420 g./lit. of hydrochloric acid at 90.degree. to 130.degree. C., eliminating the iron from the slurry of from a solution obtained by filtration of the slurry, with an anion exchange resin or semipermeable membrane or cloth, continuously or discontinuously, eluting the iron from the ion exchange resin and recycling hydrochloric acid and sulfuric acid in a closed system.

Abstract translation: 本发明涉及从低级铝和铁载体制备氧化铝和氧化铁的方法。 除了常规技术步骤之外，这些方法包括将研磨的矿物材料的铁含量溶解在含有200至420g / L的盐酸水溶液中的步骤。 的盐酸在90至130℃下，从阴离子交换树脂或半透膜或布连续或不连续地从通过过滤浆液获得的溶液的浆料中除去铁，从离子中洗脱铁 交换树脂，并在封闭系统中回收盐酸和硫酸。

公开(公告)号：US4193998A

公开(公告)日：1980-03-18

申请号：US915379

申请日：1978-06-14

Applicant: Csaba Szantay ,  Lajos Szabo ,  Istvan Toth ,  Erzsebet Kanyo ,  Gyula Sebestyen ,  Sandor Virag

Inventor： Csaba Szantay ,  Lajos Szabo ,  Istvan Toth ,  Erzsebet Kanyo ,  Gyula Sebestyen ,  Sandor Virag

IPC: C07D221/02 ,  A61K31/47 ,  A61K31/4745 ,  A61P1/04 ,  A61P25/04 ,  A61P29/00 ,  C07D455/03 ,  C07D455/06 ,  C07D491/147

CPC classification number: C07D455/00 ,  C07D455/06

Abstract: There are provided new compounds of the formula I ##STR1## wherein both R.sup.1 moieties stand for an alkyl group having 1 to 4 carbon atoms or form together a methylene bridge,R.sup.2 is cyano or an alkoxycarbonyl group having 1 to 4 carbon atoms in the alkoxy position,R.sup.3 is hydroxy or alkanoyloxy having 1 to 4 carbon atoms in the alkoxy position in .alpha.-position or .beta.-steric position,and acid addition salts thereof. There is also provided a process for the preparation of the compounds of the formula I.

Abstract translation: 提供了新的式I化合物，其中两个R 1部分代表具有1至4个碳原子的烷基或一起形成亚甲基桥，R 2是氰基或具有1至4个碳原子的烷氧基羰基， 烷氧基的位置，R3是羟基或在α位或β-位的烷氧基位置具有1至4个碳原子的烷酰氧基及其酸加成盐。 还提供了制备式I化合物的方法。