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1.发明授权公开(公告)号：US08198250B2
公开(公告)日：2012-06-12
申请号：US12170078
申请日：2008-07-09
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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2.发明授权公开(公告)号：US08258110B2
公开(公告)日：2012-09-04
申请号：US12170132
申请日：2008-07-09
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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3.发明授权公开(公告)号：US08252759B2
公开(公告)日：2012-08-28
申请号：US12170157
申请日：2008-07-09
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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公开(公告)号：US07807650B2
公开(公告)日：2010-10-05
申请号：US11858579
申请日：2007-09-20
CPC分类号： A61K31/7115 , A61K31/00 , Y02A50/486
摘要： Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
摘要翻译： 公开了用于治疗肠疾病如IBD和克罗恩病的方法和组合物。 优选的组合物包括siNA。 还公开了专门靶向siNA以通过直肠内施用siNA化合物治疗肠道疾病的方法。
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5.发明授权公开(公告)号：US08252758B2
公开(公告)日：2012-08-28
申请号：US12170148
申请日：2008-07-09
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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6.发明授权Methods and compositions for the treatment of eye disorders with increased intraocular pressure 有权用于治疗眼睛压力升高的眼部疾病的方法和组合物公开(公告)号：US07902169B2
公开(公告)日：2011-03-08
申请号：US12563530
申请日：2009-09-21
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
摘要翻译： 本发明涉及降低眼睛眼内压（IOP）的方法和组合物。 本发明的组合物包含短干扰核酸分子（siNA），包括但不限于减少与眼内液的产生或引流相关基因表达的siRNA。 本发明的组合物可用于制备用于治疗眼睛症状的药物，所述眼部病症显示增加的眼压，例如青光眼，感染，炎症，葡萄膜炎和糖尿病性视网膜病变。 本发明的方法包括向有需要的患者施用有效量的本发明的一种或多种siNA。
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7.发明授权Methods and compositions for the treatment of eye disorders with increased intraocular pressure 有权用于治疗眼睛压力升高的眼部疾病的方法和组合物公开(公告)号：US07592325B2
公开(公告)日：2009-09-22
申请号：US11360305
申请日：2006-02-22
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
摘要翻译： 本发明涉及降低眼睛眼内压（IOP）的方法和组合物。 本发明的组合物包含短干扰核酸分子（siNA），包括但不限于减少与眼内液的产生或引流相关基因表达的siRNA。 本发明的组合物可用于制备用于治疗眼睛症状的药物，所述眼部病症显示增加的眼压，例如青光眼，感染，炎症，葡萄膜炎和糖尿病性视网膜病变。 本发明的方法包括向有需要的患者施用有效量的本发明的一种或多种siNA。
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8.发明授权公开(公告)号：US08389490B2
公开(公告)日：2013-03-05
申请号：US12874928
申请日：2010-09-02
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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公开(公告)号：US20100317720A1
公开(公告)日：2010-12-16
申请号：US12871366
申请日：2010-08-30
CPC分类号： A61K31/7115 , A61K31/00 , Y02A50/486
摘要： Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
摘要翻译： 公开了用于治疗肠疾病如IBD和克罗恩病的方法和组合物。 优选的组合物包括siNA。 还公开了专门靶向siNA以通过直肠内施用siNA化合物治疗肠道疾病的方法。
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10.发明申请公开(公告)号：US20100022623A1
公开(公告)日：2010-01-28
申请号：US12563530
申请日：2009-09-21
IPC分类号： A61K31/7088 , A61P27/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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