公开(公告)号：US20070021448A1

公开(公告)日：2007-01-25

申请号：US10575683

申请日：2004-10-14

申请人： Hyunsil Han ,  Gang Lin ,  Carl Nathan

发明人： Hyunsil Han ,  Gang Lin ,  Carl Nathan

IPC分类号： A61K31/519 ,  A61K31/4709 ,  A61K31/428 ,  A61K31/4152

CPC分类号： A61K31/425 ,  A61K31/415 ,  C07D231/22 ,  C07D277/74 ,  C07D495/04 ,  Y02A50/414 ,  Y02A50/423 ,  Y02A50/475

摘要： The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without or inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.

摘要翻译： 本发明涉及在有效治疗炎症性疾病的条件下，用有效量的本申请所述通式（I）的化合物治疗受试者的炎症性疾病的方法。 本发明还涉及一种通过使嗜中性粒细胞与上述化合物接触而抑制嗜中性粒细胞呼吸爆发而不抑制或抑制嗜中性粒细胞脱颗粒或细菌性杀伤的方法。

公开(公告)号：US07977366B2

公开(公告)日：2011-07-12

申请号：US10575683

申请日：2004-10-14

申请人： Hyunsil Han ,  Gang Lin ,  Carl Nathan

发明人： Hyunsil Han ,  Gang Lin ,  Carl Nathan

IPC分类号： A61K31/4709 ,  A61K31/41 ,  A61P37/00

CPC分类号： A61K31/425 ,  A61K31/415 ,  C07D231/22 ,  C07D277/74 ,  C07D495/04 ,  Y02A50/414 ,  Y02A50/423 ,  Y02A50/475

摘要： The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.

摘要翻译： 本发明涉及在有效治疗炎症性疾病的条件下，用有效量的本申请所述通式（I）的化合物治疗受试者的炎症性疾病的方法。 本发明还涉及一种抑制嗜中性粒细胞呼吸爆发的方法，而不会通过将嗜中性粒细胞与上述化合物接触而抑制嗜中性粒细胞的脱粒或细菌杀伤。