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1.发明授权Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof 有权荧光染料标记的葡萄糖生物探针，其合成方法和用途公开(公告)号：US08679854B2
公开(公告)日：2014-03-25
申请号：US12532913
申请日：2007-12-21
申请人： Seung Bum Park , Myung Haing Cho , Hyang Yeon Lee , Jong Min Park
发明人： Seung Bum Park , Myung Haing Cho , Hyang Yeon Lee , Jong Min Park
IPC分类号： G01N21/76
CPC分类号： C07H3/00
摘要： The present invention relates to a fluorescent dye-labeled glucose analog, and a synthesis method and usage of the same, and more particularly, to novel glucose α and β anomers in which a fluorescent dye is labeled by O-1-glycosylation, an asymmetric synthesis method of the anomers, a molecular bioimaging method of the anomers, and a screening method of curing or preventing drugs for diseases related to glucose metabolism.
摘要翻译： 荧光染料标记的葡萄糖类似物及其合成方法和用途本发明涉及荧光染料标记的葡萄糖类似物，更具体地说，涉及新型葡萄糖α和β- 荧光染料由O-1-糖基化标记的前体，前体的不对称合成方法，前体的分子生物成像方法，以及用于治疗或预防与葡萄糖代谢相关的疾病的药物的筛选方法。
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2.发明申请FLUORESCENT DYE-LABELED GLUCOSE BIOPROBE, SYNTHESIS METHOD AND USAGE THEREOF 有权荧光标记的葡萄糖生物色素，合成方法及其用途公开(公告)号：US20100105149A1
公开(公告)日：2010-04-29
申请号：US12532913
申请日：2007-12-21
申请人： Seung Bum Park , Myung Haing Cho , Hyang Yeon Lee , Jong Min Park
发明人： Seung Bum Park , Myung Haing Cho , Hyang Yeon Lee , Jong Min Park
CPC分类号： C07H3/00
摘要： The present invention relates to a fluorescent dye-labeled glucose analog, and a synthesis method and usage of the same, and more particularly, to novel glucose α and β anomers in which a fluorescent dye is labeled by O-1-glycosylation, an asymmetric synthesis method of the anomers, a molecular bioimaging method of the anomers, and a screening method of curing or preventing drugs for diseases related to glucose metabolism.
摘要翻译： 荧光染料标记的葡萄糖类似物及其合成方法和用途本发明涉及荧光染料标记的葡萄糖类似物，更具体地说，涉及新型葡萄糖α和β- 荧光染料由O-1-糖基化标记的前体，前体的不对称合成方法，前体的分子生物成像方法，以及用于治疗或预防与葡萄糖代谢相关的疾病的药物的筛选方法。
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3.发明授权Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof 有权荧光染料标记的葡萄糖生物探针，其合成方法和用途公开(公告)号：US08772463B2
公开(公告)日：2014-07-08
申请号：US12876520
申请日：2010-09-07
申请人： Seung Bum Park , Hyang Yeon Lee , Jong Min Park
发明人： Seung Bum Park , Hyang Yeon Lee , Jong Min Park
IPC分类号： C07H17/02
CPC分类号： C07H15/26
摘要： Disclosed are a novel fluorescent glucose analogue, a method for the synthesis thereof and the use thereof. The novel fluorescent glucose analogue is labeled with fluorescent dye by O-1-glycosylation and via various linkers. The fluorescent glucose analogue can be applied to molecular bioimaging and a method for screening curative or preventive drugs for glucose metabolism-related diseases.
摘要翻译： 公开了一种新型荧光葡萄糖类似物，其合成方法及其应用。 新型荧光葡萄糖类似物通过O-1-糖基化和通过各种接头用荧光染料标记。 荧光葡萄糖类似物可用于分子生物成像和用于筛选用于葡萄糖代谢相关疾病的治疗或预防药物的方法。
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4.发明申请FLUORESCENT DYE-LABELED GLUCOSE BIOPROBE, SYNTHESIS METHOD AND USAGE THEREOF 有权荧光标记的葡萄糖生物色素，合成方法及其用途公开(公告)号：US20110059477A1
公开(公告)日：2011-03-10
申请号：US12876520
申请日：2010-09-07
申请人： Seung Bum PARK , Hyang Yeon LEE , Jong Min PARK
发明人： Seung Bum PARK , Hyang Yeon LEE , Jong Min PARK
CPC分类号： C07H15/26
摘要： Disclosed are a novel fluorescent glucose analogue, a method for the synthesis thereof and the use thereof. The novel fluorescent glucose analogue is labeled with fluorescent dye by O-1-glycosylation and via various linkers. The fluorescent glucose analogue can be applied to molecular bioimaging and a method for screening curative or preventive drugs for glucose metabolism-related diseases.
摘要翻译： 公开了一种新型荧光葡萄糖类似物，其合成方法及其应用。 新型荧光葡萄糖类似物通过O-1-糖基化和通过各种接头用荧光染料标记。 荧光葡萄糖类似物可用于分子生物成像和用于筛选用于葡萄糖代谢相关疾病的治疗或预防药物的方法。
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5.发明授权Two photon tracer, method for the preparation thereof and the use thereof in screening anticancer agents 有权两种光子示踪剂，其制备方法及其在抗癌剂筛选中的应用公开(公告)号：US08632749B2
公开(公告)日：2014-01-21
申请号：US12876367
申请日：2010-09-07
申请人： Seung Bum Park , Bong Rae Cho , Hyang Yeon Lee , Jong Min Park
发明人： Seung Bum Park , Bong Rae Cho , Hyang Yeon Lee , Jong Min Park
CPC分类号： A61B5/00 , A61K49/0004 , A61K49/0021 , A61K49/0052 , C07H15/18 , C07H15/26 , C12Q1/54 , G01N33/574 , G01N33/58 , G01N2500/00
摘要： Disclosed herein are compounds useful as two-photon tracers. Also, methods are provided for visualizing intracellular glucose uptake, screening anticancer agents, and diagnosing cancer using the compounds. They exhibit preferential uptake by cancer cells, penetrability sufficient to allow bright section images, high water solubility, high pH resistance and low toxicity in addition to applicability to living cells in deep tissues over a long period of time.
摘要翻译： 本文公开了可用作双光子示踪剂的化合物。 此外，提供了用于使细胞内葡萄糖摄取可视化，筛选抗癌剂和使用该化合物诊断癌症的方法。 除了适用于长时间深层组织中的活细胞外，它们表现出癌细胞的优先摄取，足以允许亮片图像，高水溶性，高耐pH和低毒性的渗透性。
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6.发明申请TWO PHOTON TRACER, METHOD FOR THE PREPARATION THEREOF AND THE USE THEREOF IN SCREENING ANTICANCER AGENTS 有权两个光子跟踪器，其制备方法及其在筛选反应物代理中的用途公开(公告)号：US20110059022A1
公开(公告)日：2011-03-10
申请号：US12876367
申请日：2010-09-07
申请人： Seung Bum PARK , Bong Rae CHO , Hyang Yeon LEE , Jong Min PARK
发明人： Seung Bum PARK , Bong Rae CHO , Hyang Yeon LEE , Jong Min PARK
CPC分类号： A61B5/00 , A61K49/0004 , A61K49/0021 , A61K49/0052 , C07H15/18 , C07H15/26 , C12Q1/54 , G01N33/574 , G01N33/58 , G01N2500/00
摘要： Disclosed herein are compounds useful as two-photon tracers. Also, methods are provided for visualizing intracellular glucose uptake, screening anticancer agents, and diagnosing cancer using the compounds. They exhibit preferential uptake by cancer cells, penetrability sufficient to allow bright section images, high water solubility, high pH resistance and low toxicity in addition to applicability to living cells in deep tissues over a long period of time.
摘要翻译： 本文公开了可用作双光子示踪剂的化合物。 此外，提供了用于使细胞内葡萄糖摄取可视化，筛选抗癌剂和使用该化合物诊断癌症的方法。 除了适用于长时间深层组织中的活细胞外，它们表现出癌细胞的优先摄取，足以允许亮片图像，高水溶性，高耐pH和低毒性的渗透性。
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