公开(公告)号：US20110236430A1

公开(公告)日：2011-09-29

申请号：US13012767

申请日：2011-01-24

Applicant: Jiang-Jen Lin ,  Hong-Lin Su ,  Fu-Chuo Peng ,  Chia-Yu Chu ,  Ying-Fang Chiu ,  Pei-Ru Li ,  Hsi-Tai Sun

Inventor： Jiang-Jen Lin ,  Hong-Lin Su ,  Fu-Chuo Peng ,  Chia-Yu Chu ,  Ying-Fang Chiu ,  Pei-Ru Li ,  Hsi-Tai Sun

IPC: A61K33/24 ,  A61K9/00 ,  A61K33/00 ,  A61K33/38 ,  A61K33/34 ,  A61K33/26 ,  A61P17/02 ,  A61P31/00 ,  B82Y5/00

CPC classification number: A61K47/02 ,  A61K33/06 ,  A61K33/24 ,  A61K33/26 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  B82Y5/00 ,  A61K2300/00

Abstract: The present invention provides a method for controlling toxicity of metallic particles and a low-toxicity composite of metallic nanoparticles and inorganic clay. The metallic nanoparticles are effective in preventing infection and in skinning over, and thus suitable for treating scalds/burns. In the composite, the weight ratio of metallic nanoparticles to inorganic clay preferably ranges 0.1/99.9 to 6.0/94.0 in a size of about 5 to 100 nm. Preferably, the metal is silver and the inorganic clay is nano silicate platelets.

Abstract translation: 本发明提供一种控制金属颗粒毒性的方法和金属纳米粒子和无机粘土的低毒复合物。 金属纳米粒子有效预防感染和皮肤剥落，因此适合于治疗烫伤/烧伤。 在复合材料中，金属纳米粒子与无机粘土的重量比优选为约5〜100nm的0.1 / 99.9〜6.0 / 94.0的范围。 优选地，金属是银，无机粘土是纳米硅酸盐血小板。

公开(公告)号：US20130157358A1

公开(公告)日：2013-06-20

申请号：US13485914

申请日：2012-05-31

Applicant: Hong-Lin Su ,  Sheng-Mei Chen

Inventor： Hong-Lin Su ,  Sheng-Mei Chen

IPC: C12N5/0797 ,  C12N5/0735

CPC classification number: C12N5/0623 ,  C12N2501/115 ,  C12N2501/415 ,  C12N2506/02

Abstract: The present invention discloses a neural induction medium comprising Wnt-signal agonist, TGFβ-signal inhibitor and FGF-signal agonist for inducing neural differentiation. The neural induction medium used in a culture system is capable for inducing the neural differentiation of stem cells into neuroepithelial cells which are useful for the clinical applications. Therein, the neuroepithelial cells can further differentiate into mature neurons for the practical applications including regeneration medicine and drug discovery for neural disorders.

Abstract translation: 本发明公开了包含Wnt信号激动剂，TGFbeta信号抑制剂和FGF信号激动剂用于诱导神经分化的神经诱导培养基。 在培养系统中使用的神经诱导培养基能够将干细胞的神经分化诱导成用于临床应用的神经上皮细胞。 其中，神经上皮细胞可进一步分化为成熟神经元用于实际应用，包括神经障碍的再生医学和药物发现。

公开(公告)号：US20120288553A1

公开(公告)日：2012-11-15

申请号：US13549414

申请日：2012-07-14

Applicant: Jiang-Jen Lin ,  Hong-Lin Su ,  Fu-Chuo Peng ,  Chia-Yu Chu ,  Ying-Fang Chiu ,  Pei-Ru Li ,  Hsi-Tai Sun

Inventor： Jiang-Jen Lin ,  Hong-Lin Su ,  Fu-Chuo Peng ,  Chia-Yu Chu ,  Ying-Fang Chiu ,  Pei-Ru Li ,  Hsi-Tai Sun

IPC: A61K33/38 ,  A61K33/34 ,  A61K33/26 ,  A61P17/02 ,  A61P31/04 ,  A61K33/24 ,  A61K9/70 ,  B82Y40/00 ,  B82Y5/00

CPC classification number: A61K47/02 ,  A61K33/06 ,  A61K33/24 ,  A61K33/26 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  B82Y5/00 ,  A61K2300/00

Abstract: The present invention provides a method for controlling toxicity of metallic particles and a low-toxicity composite of metallic nanoparticles and inorganic clay. The metallic nanoparticles are effective in preventing infection and in skinning over, and thus suitable for treating scalds/burns. In the composite, the weight ratio of metallic nanoparticles to inorganic clay preferably ranges 0.1/99.9 to 6.0/94.0 in a size of about 5 to 100 nm. Preferably, the metal is silver and the inorganic clay is nano silicate platelets.

Abstract translation: 本发明提供一种控制金属颗粒毒性的方法和金属纳米粒子和无机粘土的低毒复合物。 金属纳米粒子有效预防感染和皮肤剥落，因此适合于治疗烫伤/烧伤。 在复合材料中，金属纳米粒子与无机粘土的重量比优选为约5〜100nm的0.1 / 99.9〜6.0 / 94.0的范围。 优选地，金属是银，无机粘土是纳米硅酸盐血小板。

公开(公告)号：US20120093907A1

公开(公告)日：2012-04-19

申请号：US13102017

申请日：2011-05-05

Applicant: Jiang-Jen Lin ,  Hong-Lin Su ,  I-Chuan Pao ,  Siou-Hong Lin

Inventor： Jiang-Jen Lin ,  Hong-Lin Su ,  I-Chuan Pao ,  Siou-Hong Lin

IPC: A01N25/26 ,  A01P15/00 ,  A01N59/16 ,  B82Y5/00

CPC classification number: A01N25/08 ,  A01N59/16 ,  B82Y5/00 ,  A01N2300/00 ,  A01N25/34

Abstract: The present invention provides a composite of spherical silver nanoparticles and layered inorganic clay. This composite can effectively inhibit the growth of silver-resistant bacteria. The layered inorganic clay serves as carriers of the silver nanoparticles and disperses them. The composite has a particle size of about 5 nm to 100 nm. The silver nanoparticles can be dispersed in an organic solvent or water.

Abstract translation: 本发明提供球形银纳米颗粒和层状无机粘土的复合物。 这种复合材料可以有效抑制耐银菌的生长。 层状无机粘土用作银纳米颗粒的载体并将其分散。 该复合物具有约5nm至100nm的粒度。 银纳米颗粒可以分散在有机溶剂或水中。

公开(公告)号：US20090148484A1

公开(公告)日：2009-06-11

申请号：US12253037

申请日：2008-10-16

Applicant: Jiang-Jen Lin ,  Chun-Yu Yang ,  Chin-Cheng Chou ,  Hong-Lin Su ,  Ta-Jen Hung

Inventor： Jiang-Jen Lin ,  Chun-Yu Yang ,  Chin-Cheng Chou ,  Hong-Lin Su ,  Ta-Jen Hung

IPC: A01N25/08 ,  B01J19/12 ,  B01J19/10 ,  A01P1/00 ,  A01N59/16

CPC classification number: A01N59/16 ,  B01J21/16 ,  B01J23/50 ,  B01J23/52 ,  B01J23/72 ,  B01J23/745 ,  B01J35/006 ,  B01J37/16 ,  A01N25/08 ,  A01N25/12 ,  A01N25/34

Abstract: A stably-dispersed composite of metal nanoparticles and inorganic clay and a method for producing the composite, in which interlayered charges of the clay are replaced with the metal ions, which are then reduced to metal particles by a reducing agent. The metal particles will not aggregate together and can be stably uniformly dispersed with particle sizes smaller than conventional metal nanoparticles, and therefore have better antibiotic effect, catalytic ability and other advantages. Antibacterials in a solvent containing 0.01 wt % or more of the metal nanoparticles and inorganic clay are prepared and confirmed to be effective.

Abstract translation: 金属纳米粒子和无机粘土的稳定分散复合体及其制造方法，其中粘土的层间电荷被金属离子代替，然后通过还原剂还原成金属粒子。 金属颗粒不会聚集在一起，并且可以稳定地均匀分散，粒度小于常规金属纳米颗粒，因此具有更好的抗生素效果，催化能力等优点。 制备含有0.01重量％以上的金属纳米粒子和无机粘土的溶剂中的抗菌剂，并证实其有效。