公开(公告)号：US09340516B2

公开(公告)日：2016-05-17

申请号：US14160699

申请日：2014-01-22

申请人： Hideyuki Itou

发明人： Hideyuki Itou

IPC分类号： C07D241/20 ,  A61K31/4965

CPC分类号： C07D241/20 ,  A61K31/4965 ,  C07B2200/13

摘要： Form-II crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide and a method of producing the crystal are provided. The Form-II crystal exhibits diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2θ when the spectrum is obtained by using Cu Kα radiation: 9.0 degrees, 12.9 degrees, 20.7 degrees, and 22.6 degrees. The Form-II crystal can be produced by crystallizing the subject compound from an alcoholic solvent, a ketone solvent, a saturated hydrocarbon solvent, an ether solvent, water, or a mixture of these solvents. The crystal may be administered as an active ingredient to a subject for the purpose of treating or preventing certain diseases, disorders, and symptoms, or for promoting angiogenesis or gene therapy. The targeted diseases and disorders include transient ischemic attack, diabetic neuropathy, diabetic gangrene, peripheral circulatory disturbance, connective tissue disease, reocclusion/restenosis after percutaneous transluminal coronary angioplasty, arteriosclerosis, thrombosis, hypertension, pulmonary hypertension, and diabetic nephropathy.

摘要翻译： 提供2- {4- [N-（5,6-二苯基吡嗪-2-基）-N-异丙基氨基]丁氧基} -N-（甲基磺酰基）乙酰胺的II型晶体及其制备方法。 II型晶体在X射线粉末衍射光谱中至少在以下衍射角2θ处显示衍射峰; 当使用CuKα辐射获得光谱时：9.0度，12.9度，20.7度和22.6度。 II型晶体可以通过从醇溶剂，酮溶剂，饱和烃溶剂，醚溶剂，水或这些溶剂的混合物中使目标化合物结晶来制备。 为了治疗或预防某些疾病，病症和症状，或用于促进血管生成或基因治疗，晶体可作为活性成分施用于受试者。 目标疾病和病症包括短暂性脑缺血发作，糖尿病性神经病变，糖尿病性坏疽，外周循环障碍，结缔组织病，经皮腔内冠状动脉成形术后的再闭塞/再狭窄，动脉硬化，血栓形成，高血压，肺动脉高压和糖尿病肾病。

公开(公告)号：US20100302216A1

公开(公告)日：2010-12-02

申请号：US12784603

申请日：2010-05-21

申请人： Yasuhiro HIBINO ,  Hideyuki Itou ,  Junichi Shibata ,  Hirokazu Kitamura

发明人： Yasuhiro HIBINO ,  Hideyuki Itou ,  Junichi Shibata ,  Hirokazu Kitamura

IPC分类号： H04N5/213 ,  G09G5/00 ,  G09G3/36

CPC分类号： H04N5/21 ,  H04B1/123 ,  H04B1/3805 ,  H04B15/00 ,  H04B2215/064

摘要： Deterioration of television reception sensitivity is prevented by using a noise signal generated from a noise signal source in a portable device. A first case includes a first coupling element connected to one of input parts of the noise-cancelling section in a part of a facing surface thereof. A second case includes a second coupling element supplied with a noise signal from the noise signal source in a part of a facing surface thereof. When the television signal is received with the noise signal source brought in a vicinity of the television receiving antenna, the first and second coupling elements are brought in a vicinity of each other and coupled at a high frequency so as to form a noise signal transmission section. The noise-cancelling section noise-cancels the first noise signal by a second noise signal transmitted to the noise-cancelling section via the noise signal transmission section.

摘要翻译： 通过使用从便携式设备中的噪声信号源产生的噪声信号来防止电视接收灵敏度的恶化。 第一壳体包括在其面对表面的一部分中连接到噪声消除部分的输入部分中的一个的第一耦合元件。 第二种情况包括在其面对表面的一部分中从噪声信号源提供有噪声信号的第二耦合元件。 当利用带在电视接收天线附近的噪声信号源接收电视信号时，第一和第二耦合元件彼此附近并以高频耦合，以形成噪声信号发送部分 。 噪声消除部通过经由噪声信号发送部分发送到噪声消除部分的第二噪声信号来噪声消除第一噪声信号。

公开(公告)号：US5288830A

公开(公告)日：1994-02-22

申请号：US4400

申请日：1993-01-14

申请人： Hideyuki Itou ,  Takamasa Toyoda

发明人： Hideyuki Itou ,  Takamasa Toyoda

IPC分类号： C08L83/05 ,  C08L83/07 ,  C09D183/04 ,  C09D183/07 ,  C08G77/12

CPC分类号： C09D183/04

摘要： A curable organopolysiloxane composition which comprises an organopolysiloxane having at least two vinyl groups each joined to silicon atoms in the molecule and a defined viscosity, an organohydrogenpolysiloxane of a defined formula having at least two hydrogen atoms joined to silicon atom or atoms, and a catalytic amount of a platinum group catalyst is described. This composition has good curability and is capable of yielding a cured film which has good adhesion to plastic film or paper substrates.

摘要翻译： 一种可固化的有机基聚硅氧烷组合物，其包含具有至少两个乙烯基的有机聚硅氧烷，每个乙烯基各自与分子中的硅原子相连，并具有一定的粘度，具有至少两个连接到硅原子或原子上的氢原子的具有定义的式的有机氢聚硅氧烷和催化量 的铂族催化剂。 该组合物具有良好的固化性，并且能够产生对塑料膜或纸基材具有良好粘附性的固化膜。

公开(公告)号：US09284280B2

公开(公告)日：2016-03-15

申请号：US14160641

申请日：2014-01-22

申请人： Hideyuki Itou

发明人： Hideyuki Itou

IPC分类号： C07D241/02 ,  C07D241/20 ,  A61K31/4965

CPC分类号： C07D241/20 ,  A61K31/4965 ,  C07B2200/13

摘要： A method is provided in which Form-I crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide is administered as an active ingredient to a subject for the purpose of treating or preventing certain diseases, disorders, and symptoms, or for promoting angiogenesis or gene therapy. The Form-I crystal exhibits diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2θ when the spectrum is obtained by using Cu Kα radiation: 9.4 degrees, 9.8 degrees, 17.2 degrees, and 19.4 degrees. The targeted diseases and disorders include transient ischemic attack, diabetic neuropathy, diabetic gangrene, peripheral circulatory disturbance, connective tissue disease, reocclusion/restenosis after percutaneous transluminal coronary angioplasty, arteriosclerosis, thrombosis, hypertension, pulmonary hypertension, ischemic disorder, angina, glomerulonephritis, diabetic nephropathy, chronic renal failure, allergy, bronchial asthma, ulcer, pressure ulcer (bedsore), restenosis after coronary intervention, thrombocytopenia by dialysis, the diseases in which fibrosis of organs or tissues is involved, erectile dysfunction, inflammatory bowel disease, and gastritis.

摘要翻译： 提供了一种方法，其中将2- {4- [N-（5,6-二苯基吡嗪-2-基）-N-异丙基氨基]丁氧基} -N-（甲基磺酰基）乙酰胺的I型晶体作为活性成分 以治疗或预防某些疾病，病症和症状，或用于促进血管发生或基因治疗的目的。 Form-I晶体在X射线粉末衍射光谱中至少在以下衍射角2θ处显示衍射峰; 当通过使用CuKα辐射获得光谱时：9.4度，9.8度，17.2度和19.4度。 目标疾病和障碍包括短暂性脑缺血发作，糖尿病性神经病变，糖尿病性坏疽，外周循环障碍，结缔组织病，经皮腔内冠状动脉成形术后再闭塞/再狭窄，动脉硬化，血栓形成，高血压，肺动脉高压，缺血性障碍，心绞痛，肾小球性肾炎，糖尿病 肾病，慢性肾衰竭，过敏，支气管哮喘，溃疡，压力性溃疡（褥疮），冠状动脉介入后再狭窄，透析血小板减少症，器官或组织纤维化的疾病，勃起功能障碍，炎症性肠病和胃炎。

公开(公告)号：US08791122B2

公开(公告)日：2014-07-29

申请号：US13379531

申请日：2010-06-25

申请人： Hideyuki Itou

发明人： Hideyuki Itou

IPC分类号： A61K31/4965 ,  C07D241/20

CPC分类号： C07D241/20 ,  A61K31/4965 ,  C07B2200/13

摘要： A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide (hereinafter referred to as “compound A”). A Form-I crystal of compound A shows diffraction peaks at 9.4 degrees, 9.8 degrees, 17.2 degrees and 19.4 degrees in the powder X-ray diffraction spectrum thereof. A Form-II crystal of compound A shows diffraction peaks at 9.0 degrees, 12.9 degrees, 20.7 degrees and 22.6 degrees in the powder X-ray diffraction spectrum thereof. A Form-III crystal of compound A shows diffraction peaks at 9.3 degrees, 9.7 degrees, 16.8 degrees, 20.6 degrees and 23.5 degrees in the powder X-ray diffraction spectrum thereof.

摘要翻译： 本发明的主要目的是提供2- {4- [N-（5,6-二苯基吡嗪-2-基）-N-异丙基氨基]丁氧基} -N-（甲基磺酰基）乙酰胺（以下简称为 作为“化合物A”）。 化合物A的I型晶体在其粉末X射线衍射光谱中显示9.4度，9.8度，17.2度和19.4度的衍射峰。 化合物A的II型晶体在其粉末X射线衍射光谱中显示9.0度，12.9度，20.7度和22.6度的衍射峰。 化合物A的III型晶体在其粉末X射线衍射光谱中显示出9.3度，9.7度，16.8度，20.6度和23.5度的衍射峰。

公开(公告)号：US20140155414A1

公开(公告)日：2014-06-05

申请号：US14160699

申请日：2014-01-22

申请人： Hideyuki ITOU ,  Koji NAKAMICHI ,  Takashi TOSAKA

发明人： Hideyuki ITOU ,  Koji NAKAMICHI ,  Takashi TOSAKA

IPC分类号： C07D241/20

CPC分类号： C07D241/20 ,  A61K31/4965 ,  C07B2200/13

摘要： A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide (hereinafter referred to as “compound A”). A Form-I crystal of compound A shows diffraction peaks at 9.4 degrees, 9.8 degrees, 17.2 degrees and 19.4 degrees in the powder X-ray diffraction spectrum thereof. A Form-II crystal of compound A shows diffraction peaks at 9.0 degrees, 12.9 degrees, 20.7 degrees and 22.6 degrees in the powder X-ray diffraction spectrum thereof. A Form-III crystal of compound A shows diffraction peaks at 9.3 degrees, 9.7 degrees, 16.8 degrees, 20.6 degrees and 23.5 degrees in the powder X-ray diffraction spectrum thereof.

摘要翻译： 本发明的主要目的是提供2- {4- [N-（5,6-二苯基吡嗪-2-基）-N-异丙基氨基]丁氧基} -N-（甲基磺酰基）乙酰胺（以下简称为 作为“化合物A”）。 化合物A的I型晶体在其粉末X射线衍射光谱中显示9.4度，9.8度，17.2度和19.4度的衍射峰。 化合物A的II型晶体在其粉末X射线衍射光谱中显示9.0度，12.9度，20.7度和22.6度的衍射峰。 化合物A的III型晶体在其粉末X射线衍射光谱中显示出9.3度，9.7度，16.8度，20.6度和23.5度的衍射峰。

公开(公告)号：US20120101276A1

公开(公告)日：2012-04-26

申请号：US13379531

申请日：2010-06-25

申请人： Hideyuki Itou ,  Koji Nakamichi ,  Takashi Tosaka

发明人： Hideyuki Itou ,  Koji Nakamichi ,  Takashi Tosaka

IPC分类号： C07D241/20

CPC分类号： C07D241/20 ,  A61K31/4965 ,  C07B2200/13

摘要： A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide (hereinafter referred to as “compound A”). A Form-I crystal of compound A shows diffraction peaks at 9.4 degrees, 9.8 degrees, 17.2 degrees and 19.4 degrees in the powder X-ray diffraction spectrum thereof. A Form-II crystal of compound A shows diffraction peaks at 9.0 degrees, 12.9 degrees, 20.7 degrees and 22.6 degrees in the powder X-ray diffraction spectrum thereof. A Form-III crystal of compound A shows diffraction peaks at 9.3 degrees, 9.7 degrees, 16.8 degrees, 20.6 degrees and 23.5 degrees in the powder X-ray diffraction spectrum thereof.

摘要翻译： 本发明的主要目的是提供2- {4- [N-（5,6-二苯基吡嗪-2-基）-N-异丙基氨基]丁氧基} -N-（甲基磺酰基）乙酰胺（以下简称为 作为“化合物A”）。 化合物A的I型晶体在其粉末X射线衍射光谱中显示9.4度，9.8度，17.2度和19.4度的衍射峰。 化合物A的II型晶体在其粉末X射线衍射光谱中显示9.0度，12.9度，20.7度和22.6度的衍射峰。 化合物A的III型晶体在其粉末X射线衍射光谱中显示出9.3度，9.7度，16.8度，20.6度和23.5度的衍射峰。

公开(公告)号：US20140148469A1

公开(公告)日：2014-05-29

申请号：US14160641

申请日：2014-01-22

申请人： Hideyuki ITOU

发明人： Hideyuki ITOU

IPC分类号： C07D241/20

CPC分类号： C07D241/20 ,  A61K31/4965 ,  C07B2200/13

摘要： A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide (hereinafter referred to as “compound A”). A Form-I crystal of compound A shows diffraction peaks at 9.4 degrees, 9.8 degrees, 17.2 degrees and 19.4 degrees in the powder X-ray diffraction spectrum thereof. A Form-II crystal of compound A shows diffraction peaks at 9.0 degrees, 12.9 degrees, 20.7 degrees and 22.6 degrees in the powder X-ray diffraction spectrum thereof. A Form-III crystal of compound A shows diffraction peaks at 9.3 degrees, 9.7 degrees, 16.8 degrees, 20.6 degrees and 23.5 degrees in the powder X-ray diffraction spectrum thereof.

摘要翻译： 本发明的主要目的是提供2- {4- [N-（5,6-二苯基吡嗪-2-基）-N-异丙基氨基]丁氧基} -N-（甲基磺酰基）乙酰胺（以下简称为 作为“化合物A”）。 化合物A的I型晶体在其粉末X射线衍射光谱中显示9.4度，9.8度，17.2度和19.4度的衍射峰。 化合物A的II型晶体在其粉末X射线衍射光谱中显示9.0度，12.9度，20.7度和22.6度的衍射峰。 化合物A的III型晶体在其粉末X射线衍射光谱中显示出9.3度，9.7度，16.8度，20.6度和23.5度的衍射峰。

公开(公告)号：US20100253851A1

公开(公告)日：2010-10-07

申请号：US12704985

申请日：2010-02-12

申请人： Hideyuki ITOU ,  Yasuhiro Hibino ,  Junichi Shibata

发明人： Hideyuki ITOU ,  Yasuhiro Hibino ,  Junichi Shibata

IPC分类号： H04N5/217

CPC分类号： H04B1/525

摘要： A noise canceller includes an input terminal for receiving an input signal containing a received signal and a first noise signal generated by a noise source, a first delay unit for delaying the input signal, a pick-up antenna for receiving a second noise signal generated by the noise source, a cancel-signal generator for generating a noise-canceling signal based on the second noise signal, and a combiner for combining the delayed input signal and the noise-canceling signal so as to cancel the first noise signal contained in the input signal, and outputting the received signal. The noise canceller can include a second delay unit for delaying the second signal instead of the first delay unit or in addition to the first delay unit. This noise canceller cancels the noise signal generated by the noise source, thereby providing an electronic device having a preferable receiving sensitivity.

摘要翻译： 噪声消除器包括用于接收包含接收信号的输入信号和由噪声源产生的第一噪声信号的输入端，用于延迟输入信号的第一延迟单元，用于接收由第二噪声信号产生的第二噪声信号的拾取天线 噪声源，用于基于第二噪声信号产生噪声消除信号的消除信号发生器，以及用于组合延迟输入信号和噪声消除信号的组合器，以消除输入中包含的第一噪声信号 信号，并输出接收到的信号。 噪声消除器可以包括第二延迟单元，用于延迟第二信号而不是第一延迟单元，或者除了第一延迟单元之外。 该噪声消除器消除由噪声源产生的噪声信号，从而提供具有优选的接收灵敏度的电子设备。

公开(公告)号：US20090195701A1

公开(公告)日：2009-08-06

申请号：US12353400

申请日：2009-01-14

申请人： Akira Fujishima ,  Hideyuki Itou ,  Yoshikazu Matsui ,  Hirokazu Kitamura ,  Masashi Yasuda ,  Yuki Satoh

发明人： Akira Fujishima ,  Hideyuki Itou ,  Yoshikazu Matsui ,  Hirokazu Kitamura ,  Masashi Yasuda ,  Yuki Satoh

IPC分类号： H04N5/46

CPC分类号： H04N5/21 ,  H01Q1/24 ,  H04B1/126

摘要： A noise canceller of this invention includes a pickup antenna arranged in proximity to a noise signal generation source to extract a noise signal generated by the noise signal generation source, and a noise cancellation unit having a first input for receiving a television signal from a television signal receiving antenna and a second input for receiving the noise signal extracted by the pickup antenna. Herein, the noise cancellation unit removes a noise signal fed from the television signal receiving antenna. Thus, the noise canceller prevents degradation in television signal reception sensitivity due to the noise signal generated by the noise signal generation source.

摘要翻译： 本发明的噪声消除器包括：拾音天线，布置在噪声信号发生源附近，以提取由噪声信号产生源产生的噪声信号;以及噪声消除单元，具有用于从电视信号接收电视信号的第一输入 接收天线和用于接收由拾取天线提取的噪声信号的第二输入。 这里，噪声消除单元去除从电视信号接收天线馈送的噪声信号。 因此，噪声消除器防止由噪声信号发生源产生的噪声信号导致的电视信号接收灵敏度的劣化。