公开(公告)号：US20120160281A1

公开(公告)日：2012-06-28

申请号：US13379495

申请日：2011-07-20

申请人： Hideo Hashimoto ,  Yuuki Namikawa ,  Masahiro Hashimoto ,  Takahisa Fujii

发明人： Hideo Hashimoto ,  Yuuki Namikawa ,  Masahiro Hashimoto ,  Takahisa Fujii

IPC分类号： B08B3/04

CPC分类号： D06F37/06

摘要： A washing apparatus is provided with a washing tub 2 whose rotating axis is in a horizontal direction or in a horizontally inclined direction, and has a concave and convex curve surface 22 installed on an inside wall surface of the washing tub 2 as well as has a baffle 25 protruding in the direction of the rotating axis installed. Then, by rotating the washing tub with a level of a cleaning liquid to be supplied to the washing tub 2 set to be higher than the rotating axis, a spurious non-gravity wash method is adopted in which damage to a washing article is small. In addition, by rotating the washing tub 2 with the level of the cleaning liquid to be supplied to the washing tub 2 set to be lower than the rotating axis, a beat wash method in which water saving effect is high is adopted.

摘要翻译： 洗涤装置具有旋转轴在水平方向或水平方向倾斜的洗涤桶2，并且具有安装在洗涤桶2的内壁面上的凹凸曲面22，并且具有 挡板25沿安装的旋转轴线方向突出。 然后，通过将清洗液的水平旋转至要设置为高于旋转轴线的洗涤桶2的清洗液的水平，采用了对洗涤用品的损伤小的虚假非重力洗涤方法。 此外，通过使洗涤桶2以提供给设定为低于旋转轴的洗涤桶2的清洗液的水平旋转，采用节水效果高的节拍方法。

公开(公告)号：US20110257405A1

公开(公告)日：2011-10-20

申请号：US13168121

申请日：2011-06-24

申请人： Hideo HASHIMOTO ,  Hideaki MARUYAMA

发明人： Hideo HASHIMOTO ,  Hideaki MARUYAMA

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  A61K31/4439 ,  C30B7/00

摘要： The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.

摘要翻译： 本发明涉及（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑的溶液的制备方法。 （其中n'为约0至约0.1）或其盐，其特征在于包括从有机溶剂溶液或悬浮液中结晶，其中（R）-2 - [[[3-甲基-4-（2,2,2' - 三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑nH 2 O（其中n为约0.1至约1.0）或其盐已经溶解或悬浮等，并且提供了有效制备光学活性的方便的方法 在工业上大规模地高收率地具有极高对映体过量的亚砜衍生物。

公开(公告)号：US07569696B2

公开(公告)日：2009-08-04

申请号：US11515639

申请日：2006-09-05

申请人： Hideo Hashimoto ,  Hideaki Maruyama

发明人： Hideo Hashimoto ,  Hideaki Maruyama

IPC分类号： C07D401/00

CPC分类号： C07D401/12 ,  A61K31/4439 ,  C30B7/00

摘要： The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-benzimidazole.nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.

摘要翻译： 本发明涉及（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑的溶液的制备方法。 （其中n'为约0至约0.1）或其盐，其特征在于包括从有机溶剂溶液或悬浮液中结晶，其中（R）-2 - [[[3-甲基-4-（2,2,2' - 三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] - 苯并咪唑·nH 2 O（其中n为约0.1至约1.0）或其盐已经溶解或悬浮等，并且提供了有效地制造光学 活性亚砜衍生物在工业规模上以高产率具有极高的对映体过量。

公开(公告)号：US20090030044A1

公开(公告)日：2009-01-29

申请号：US11921596

申请日：2006-06-06

申请人： Hideo Hashimoto ,  Tadashi Urai

发明人： Hideo Hashimoto ,  Tadashi Urai

IPC分类号： A61K31/4439 ,  C07D401/02 ,  A61P1/04 ,  A61P35/00 ,  A61P1/00

CPC分类号： A61K9/5078 ,  A61K9/0019 ,  A61K9/19 ,  A61K9/5026 ,  C07D401/12 ,  C30B7/06 ,  C30B29/54

摘要： A crystal of a salt of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole which is useful as a medicine, and use of the crystal.

摘要翻译： 可用作药物的2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] -1H-苯并咪唑盐的晶体，使用 水晶。

公开(公告)号：US20080306118A1

公开(公告)日：2008-12-11

申请号：US11899918

申请日：2007-09-07

申请人： Hideo Hashimoto ,  Tadashi Urai

发明人： Hideo Hashimoto ,  Tadashi Urai

IPC分类号： A61K31/435 ,  C07D401/12 ,  A61P1/02 ,  A61P35/00

CPC分类号： C07D401/12 ,  A61K9/5026 ,  A61K9/5078 ,  A61K31/44

摘要： The present invention relates to a production method of a crystal of (R)-lansoprazole or (S)-lansoprazole, which includes crystallization at a temperature of about 0° C. to about 35° C. from a C1-4 alkyl acetate solution containing (R)-lansoprazole or (S)-lansoprazole at a concentration of about 0.1 g/mL to about 0.5 g/mL and the like. According to the production method of the present invention, a crystal of (R)-lansoprazole or (S)-lansoprazole superior in preservation stability can be produced efficiently on an industrial large scale.

摘要翻译： 本发明涉及（R） - 兰索拉唑或（S） - 兰索拉唑结晶的制备方法，其包括在约0℃至约35℃的温度下从C 1-4烷基乙酸酯溶液 浓度为约0.1g / mL至约0.5g / mL的（R） - 兰索拉唑或（S） - 兰索拉唑等。 根据本发明的制造方法，能够以工业化的大规模有效地制造保存稳定性优异的（R） - 兰索拉唑或（S） - 兰索拉唑的结晶。

公开(公告)号：US20080182994A1

公开(公告)日：2008-07-31

申请号：US12073973

申请日：2008-03-12

申请人： Hideo Hashimoto ,  Hideaki Maruyama

发明人： Hideo Hashimoto ,  Hideaki Maruyama

IPC分类号： C07D403/10

CPC分类号： C07D403/10

摘要： A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.

摘要翻译： 制备2-乙氧基-1 - [[2' - （1H-四唑-5-基）联苯-4-基]甲基] -1H-苯并咪唑-7-羧酸（化合物（I））的晶体的方法， 其特征在于将化合物（I）或其盐溶解或悬浮在包含非质子极性溶剂并使其结晶的溶剂中。 通过该方法，可以容易地除去化合物（I）或其盐中难以除去的难以除去的污染物，例如锡化合物，化合物（I）的类似物和残余的有机溶剂。 化合物（I）的晶体可以在工业规模上以高产率高效且容易地批量生产。

公开(公告)号：US07248127B2

公开(公告)日：2007-07-24

申请号：US11089121

申请日：2005-03-24

申请人： Atsuhiro Ishikawa ,  Hideo Hashimoto

发明人： Atsuhiro Ishikawa ,  Hideo Hashimoto

IPC分类号： H03B5/32 ,  H03L1/00

CPC分类号： H03L1/023 ,  H03B5/362

摘要： A quartz crystal oscillator in which phase noise is reduced includes: a resonance circuit having a quartz crystal unit and a split capacitor connected to the crystal unit; a transistor for oscillation having its base connected to the node of the crystal unit and the split capacitor; an output line for connecting the mutual node of the split capacitor to the emitter of the transistor; a quartz crystal resonator that is inserted in the output line; and a temperature compensation mechanism for compensating the frequency-temperature characteristics of both the crystal unit and the crystal resonator.

摘要翻译： 相位噪声减小的石英晶体振荡器包括：具有与晶体单元连接的石英晶体单元和分离电容器的谐振电路; 用于振荡的晶体管，其基极连接到晶体单元的节点和分离电容器; 用于将分离电容器的共同节点连接到晶体管的发射极的输出线; 插入输出线的石英晶体谐振器; 以及用于补偿晶体单元和晶体谐振器的频率 - 温度特性的温度补偿机构。

公开(公告)号：US07236634B2

公开(公告)日：2007-06-26

申请号：US10703547

申请日：2003-11-10

申请人： Junichi Miyakoshi ,  Masayuki Miyama ,  Masahiko Yoshimoto ,  Hideo Hashimoto ,  Kousuke Imamura

发明人： Junichi Miyakoshi ,  Masayuki Miyama ,  Masahiko Yoshimoto ,  Hideo Hashimoto ,  Kousuke Imamura

IPC分类号： G06K9/36

CPC分类号： H04N19/61 ,  H04N19/51

摘要： In an encoding method of moving pictures which generates a predictive picture for a current picture based on a reference picture and a motion vector, a macroblock is divided into subblocks. In each of the plurality of subblocks, an initial value of the motion vector is set and an evaluated value E on a difference between the current picture and the reference picture is calculated along a steepest descent direction to determine the minimum value. Then, the smallest evaluated value is selected among the minimum values obtained on the plurality of subblocks to determine the motion vector based on the pixel position of the smallest value.

摘要翻译： 在基于参考图像和运动矢量生成当前图像的预测图像的运动图像的编码方法中，宏块被划分为子块。 在多个子块中的每一个中，设置运动矢量的初始值，并且沿最陡下降方向计算当前画面与参考画面之间的差值的评估值E，以确定最小值。 然后，从在多个子块上获得的最小值中选择最小的评估值，以基于最小值的像素位置来确定运动矢量。

公开(公告)号：US20060276421A1

公开(公告)日：2006-12-07

申请号：US10568226

申请日：2004-09-29

申请人： Yasuo Kunugiza ,  Naruya Tomita ,  Hideo Hashimoto ,  Hideki Yoshikawa ,  Ryuichi Morishita

发明人： Yasuo Kunugiza ,  Naruya Tomita ,  Hideo Hashimoto ,  Hideki Yoshikawa ,  Ryuichi Morishita

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： A61K31/713 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/51

摘要： Conventional oligonucleotides are opened at both ends and thereby unstable. The stability of them against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides a staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.

摘要翻译： 常规寡核苷酸在两端开放，从而不稳定。 它们对分解代谢酶的稳定性被硫代磷酸酯修饰增加，但是这种硫代磷酸酯引起毒性。 本发明提供了改善这些问题的寡核苷酸和药物。 也就是说，它提供了含有与活性成分相同的主要寡核苷酸和药物。 具体来说，它提供转录因子抑制剂，反义寡核苷酸和siRNA。 更具体地说，它提供用于预防，治疗或改善炎症，自身免疫性疾病，中枢性疾病，缺血性疾病中的再灌注损伤，器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。 更具体地说，它提供预防，治疗或改善关节炎，皮炎，肾炎，肝炎，肾衰竭，膀胱炎，前列腺炎，尿道炎，溃疡性结肠炎，克罗恩病，慢性类风湿性关节炎，骨关节炎，特应性皮炎，接触性皮炎，牛皮癣，皮肤 溃疡或褥疮。

公开(公告)号：US07075381B2

公开(公告)日：2006-07-11

申请号：US10824578

申请日：2004-04-14

申请人： Hideo Hashimoto

发明人： Hideo Hashimoto

IPC分类号： H03B5/32 ,  H03B5/30 ,  H03B5/36 ,  H03B5/12 ,  H03L1/00

CPC分类号： H03B5/368 ,  H03B5/32 ,  H03B5/36

摘要： The present invention relates to a crystal oscillator circuit in which the output level is maintained to prevent changes in oscillation frequency due to variations in power voltage. This crystal oscillator circuit comprises a resonance circuit formed of a crystal oscillator (which acts as an inductor component) and dividing capacitors, an oscillation amplifier formed of ECL circuitry driven by a power voltage connected to the resonance circuit, and a pull-down resistor between an output terminal of the ECL circuit and ground. The pull-down resistor acts as serially-connected dividing resistors and also a bias capacitor is provided between a connection point between those dividing resistors and ground. The present invention also relates to a frequency-switching oscillator having a simple circuit design and a small number of components. This frequency-switching oscillator enables a configuration in which an oscillation amplifier that is a two input, two output type of ECL circuit having mutually inverted signals is connected to a resonance circuit formed of a crystal oscillator and dividing capacitors; a first resonance circuit provided with a first electronic switch is connected between one pair of input-output terminals for mutually inverted signals of the ECL circuit; a second resonance circuit is connected between another pair of input-output terminals for mutually inverted signals of the ECL circuit; and the resonance frequencies of the first and second resonance circuits are different and also the first and second electronic switches are switched to select one of the resonance circuits.

摘要翻译： 本发明涉及一种晶体振荡器电路，其中保持输出电平以防止由于电源电压的变化引起的振荡频率的变化。 该晶体振荡器电路包括由晶体振荡器（其作为电感器部件）和分压电容器形成的谐振电路，由连接到谐振电路的电源电压驱动的ECL电路形成的振荡放大器和在谐振电路之间的下拉电阻器 ECL电路的输出端和地。 下拉电阻用作串联连接的分压电阻，并且在这些分压电阻和地之间的连接点之间还提供偏置电容。 本发明还涉及具有简单电路设计和少量部件的频率切换振荡器。 该频率切换振荡器能够实现将作为具有相互反转信号的两输入型ECL电路的振荡放大器连接到由晶体振荡器和分频电容器构成的谐振电路的结构; 设置有第一电子开关的第一谐振电路连接在用于ECL电路的相互反转信号的一对输入 - 输出端子之间; 第二谐振电路连接在另一对输入输出端子之间，用于ECL电路的相互反转的信号; 并且第一和第二谐振电路的谐振频率不同，并且第一和第二电子开关被切换以选择谐振电路之一。