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1.发明申请SALTS OF BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION METHOD AND USE THEREOF 有权双相取代的吡唑啉偶氮衍生物的制备方法及其用途公开(公告)号：US20120164102A1
公开(公告)日：2012-06-28
申请号：US13377342
申请日：2010-05-28
申请人： Peng Cho Tang , Hejun Lü , Hongbo Fei , Yiqian Chen
发明人： Peng Cho Tang , Hejun Lü , Hongbo Fei , Yiqian Chen
IPC分类号： A61K38/20 , A61K38/00 , A61K38/18 , A61K31/497 , A61K31/415 , A61K38/19 , C07D409/12 , C07D231/44 , C07D405/12 , C07D405/14 , C07D409/14 , A61K39/395 , C07D403/02
CPC分类号： C07D231/46 , A61K31/4152 , A61K31/4155 , A61K45/06 , C07C211/05 , C07C211/27 , C07C215/08 , C07C215/10 , C07C215/40 , C07C279/14 , C07D295/027 , C07D405/12 , C07D409/12
摘要： The pharmaceutically acceptable salts of bicycle-substituted pyrazolon azo derivatives represented by the general formula (I), their preparation methods, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definitions of substituents in the general formula (I) are the same as the description.
摘要翻译： 由通式（I）表示的自行车取代的吡唑啉偶氮衍生物的药学上可接受的盐，其制备方法，含有它们的药物组合物及其作为治疗剂的用途，特别是血小板生成素（TPO）模拟物及其作为激动剂的用途 血小板生成素受体。 通式（I）中的取代基的定义与说明书相同。
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2.发明申请SALTS OF BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION METHOD AND USE THEREOF 有权双相取代的吡唑啉偶氮衍生物的制备方法及其用途公开(公告)号：US20140140953A1
公开(公告)日：2014-05-22
申请号：US14164834
申请日：2014-01-27
申请人： Peng Cho Tang , Hejun Lü , Hongbo Fei , Yiqian Chen
发明人： Peng Cho Tang , Hejun Lü , Hongbo Fei , Yiqian Chen
IPC分类号： C07D231/46 , C07C215/08 , C07C211/05 , C07D295/027 , C07D405/12 , A61K31/4155 , C07C215/10 , C07C211/27 , C07C279/14 , C07D409/12 , A61K31/4152 , A61K45/06 , C07C215/40
CPC分类号： C07D231/46 , A61K31/4152 , A61K31/4155 , A61K45/06 , C07C211/05 , C07C211/27 , C07C215/08 , C07C215/10 , C07C215/40 , C07C279/14 , C07D295/027 , C07D405/12 , C07D409/12
摘要： The pharmaceutically acceptable salts of bicycle-substituted pyrazolon azo derivatives represented by the general formula (I), their preparation methods, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definitions of substituents in the general formula (I) are the same as the description.
摘要翻译： 由通式（I）表示的自行车取代的吡唑啉偶氮衍生物的药学上可接受的盐，其制备方法，含有它们的药物组合物及其作为治疗剂的用途，特别是血小板生成素（TPO）模拟物及其作为激动剂的用途 血小板生成素受体。 通式（I）中的取代基的定义与说明书相同。
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3.发明授权Bicyclo-substituted pyrazolon azo derivatives, preparation process and pharmaceutical use thereof 有权双环取代的吡唑啉偶氮衍生物，其制备方法和药物用途公开(公告)号：US08367710B2
公开(公告)日：2013-02-05
申请号：US12812119
申请日：2009-01-04
申请人： Peng Cho Tang , Hejun Lü , Hao Zheng , Yiqian Chen , Hongbo Fei , Shenglan Wang , Li Wang
发明人： Peng Cho Tang , Hejun Lü , Hao Zheng , Yiqian Chen , Hongbo Fei , Shenglan Wang , Li Wang
IPC分类号： A61K31/4196 , A61K31/41 , A61K38/20 , C07D231/46 , C07D403/12 , C07D405/10 , C07D231/26 , A61P7/00
CPC分类号： C07D417/12 , C07D231/08 , C07D231/22 , C07D231/38 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/12
摘要： The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.
摘要翻译： 式（I）的双环取代的吡唑并 - 偶氮衍生物或其药学上可接受的盐，水合物或溶剂合物，其制备方法，含有它们的药物组合物及其作为治疗剂的用途，特别是血小板生成素（TPO）模拟物及其 用作血小板生成素受体的激动剂。 式（I）中取代基的定义与描述中定义相同。
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4.发明授权Dicycloazaalkane derivatives, preparation processes and medical uses thereof 有权二环烷基烷烃衍生物，其制备方法和医疗用途公开(公告)号：US08415349B2
公开(公告)日：2013-04-09
申请号：US13619138
申请日：2012-09-14
申请人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
发明人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
IPC分类号： A61K31/5377 , A61K31/403 , A61K31/454 , C07D403/12 , C07D401/14 , C07D413/14
CPC分类号： C07D209/52 , C07D403/12
摘要： The invention provides derivatives of azabicyclo alkane having formula (ID), and the method for making them, wherein each substitute in formula (ID) is same as defined in the description.
摘要翻译： 本发明提供具有式（ID）的氮杂双环烷烃衍生物及其制备方法，其中式（ID）中的每个取代基与说明书中定义相同。
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5.发明申请DERIVATIVES OF AZABICYCLO OCTANE, THE METHOD OF MAKING THEM AND THE USES THEREOF AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV 有权亚硫酸氢钙衍生物，其制备方法及其作为DIPEPTIDYL PEPTIDASE IV的抑制剂的用途公开(公告)号：US20100016314A1
公开(公告)日：2010-01-21
申请号：US12518259
申请日：2007-10-30
申请人： Pengcho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li
发明人： Pengcho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li
IPC分类号： A61K31/5377 , C07D209/02 , A61K31/403 , C07D401/14 , A61K31/454 , C07D413/14 , A61P3/10
CPC分类号： C07D403/12 , C07D209/52
摘要： Derivatives of azabicyclo octane presented by formula (I), the method of making them, and the compositions containing the same and the uses thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV), wherein the substitutes in formula (I) have the same meanings as what is mentioned in the descriptions.
摘要翻译： 由式（I）表示的氮杂二环辛烷衍生物，其制备方法和含有该衍生物的组合物及其作为二肽基肽酶IV（DPP-IV）抑制剂的用途，其中式（I）中的取代基具有相同 意义与描述中提到的相同。
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6.发明授权Salts of bicyclo-substituted pyrazolon azo derivatives, preparation method and use thereof 有权双环取代的吡唑啉偶氮衍生物的盐，其制备方法和用途公开(公告)号：US08642637B2
公开(公告)日：2014-02-04
申请号：US13377342
申请日：2010-05-28
申请人： Peng Cho Tang , Hejun Lü , Hongbo Fei , Yiqian Chen
发明人： Peng Cho Tang , Hejun Lü , Hongbo Fei , Yiqian Chen
IPC分类号： A61K31/4152 , C07D231/08
CPC分类号： C07D231/46 , A61K31/4152 , A61K31/4155 , A61K45/06 , C07C211/05 , C07C211/27 , C07C215/08 , C07C215/10 , C07C215/40 , C07C279/14 , C07D295/027 , C07D405/12 , C07D409/12
摘要： The pharmaceutically acceptable salts of bicyclo-substituted pyrazolon azo derivatives represented by the general formula (I), their preparation methods, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definitions of substituents in the general formula (I) are the same as the description.
摘要翻译： 由通式（I）表示的双环取代的吡唑啉偶氮衍生物的药学上可接受的盐，其制备方法，含有它们的药物组合物及其作为治疗剂的用途，特别是血小板生成素（TPO）模拟物及其作为激动剂的用途 血小板生成素受体。 通式（I）中的取代基的定义与说明书相同。
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7.发明申请DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF 有权DICYCLOAZAALKANE衍生物，其制备方法及其医疗用途公开(公告)号：US20130012705A1
公开(公告)日：2013-01-10
申请号：US13619138
申请日：2012-09-14
申请人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
发明人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
IPC分类号： C07D209/52 , C07D413/06 , C07D403/06 , C07D401/06
CPC分类号： C07D209/52 , C07D403/12
摘要： Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.
摘要翻译： 公开了由通式（I）表示的新的二环唑烷衍生物，其制备方法和含有它们的药物组合物，以及特别用于二肽基肽酶抑制剂（DPP-IV）的用途，其中通式（I）的每个取代基为 在规范中定义。
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8.发明授权Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV 有权氮杂二环辛烷的衍生物，其制备方法及其作为二肽基肽酶IV抑制剂的用途公开(公告)号：US08178575B2
公开(公告)日：2012-05-15
申请号：US12518259
申请日：2007-10-30
申请人： Pengcho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li
发明人： Pengcho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li
IPC分类号： A61K31/40 , C07D209/00
CPC分类号： C07D403/12 , C07D209/52
摘要： Derivatives of azabicyclo octane presented by formula (I), the method of making them, and the compositions containing the same and the uses thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV), wherein the substitutes in formula (I) have the same meanings as what is mentioned in the descriptions.
摘要翻译： 由式（I）表示的氮杂二环辛烷衍生物，其制备方法和含有该衍生物的组合物及其作为二肽基肽酶IV（DPP-IV）抑制剂的用途，其中式（I）中的取代基具有相同 意义与描述中提到的相同。
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9.发明申请BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF 有权双羟基取代的吡唑啉偶氮衍生物，其制备方法和药物用途公开(公告)号：US20100316601A1
公开(公告)日：2010-12-16
申请号：US12812119
申请日：2009-01-04
申请人： Peng Cho Tang , Hejun Lü , Hao Zheng , Yiqian Chen , Hongbo Fel , Shenglan Wang , Li Wang
发明人： Peng Cho Tang , Hejun Lü , Hao Zheng , Yiqian Chen , Hongbo Fel , Shenglan Wang , Li Wang
IPC分类号： A61K31/4196 , C07D231/46 , C07D403/12 , C07D405/10 , C07D231/26 , A61K31/41 , A61K38/20 , A61P7/00
CPC分类号： C07D417/12 , C07D231/08 , C07D231/22 , C07D231/38 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/12
摘要： The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.
摘要翻译： 式（I）的双环取代的吡唑并 - 偶氮衍生物或其药学上可接受的盐，水合物或溶剂合物，其制备方法，含有它们的药物组合物及其作为治疗剂的用途，特别是血小板生成素（TPO）模拟物及其 用作血小板生成素受体的激动剂。 式（I）中取代基的定义与描述中定义相同。
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