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公开(公告)号：US09469627B2
公开(公告)日：2016-10-18
申请号：US13439511
申请日：2012-04-04
IPC分类号： C07D413/14 , A61K31/506 , C07D271/06
CPC分类号： A61K31/506 , C07D217/06 , C07D271/06 , C07D413/14
摘要： This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
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公开(公告)号：US20120190695A1
公开(公告)日：2012-07-26
申请号：US13439511
申请日：2012-04-04
IPC分类号： A61K31/506 , A61P37/08 , A61P29/00 , A61P11/06 , A61P27/02 , A61P11/00 , C07C259/18 , C07D271/06 , C07D401/14 , C07D413/14 , A61P11/02
CPC分类号： A61K31/506 , C07D217/06 , C07D271/06 , C07D413/14
摘要： This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2和R3如本文所定义，药物组合物包含化合物，中间体和制备所述化合物的方法，以及该化合物用于治疗过敏和/ 特别是诸如过敏性鼻炎，哮喘，慢性阻塞性肺病（COPD）和年龄相关性黄斑变性（AMD）的疾病。
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3.发明申请PROCESS FOR THE PREPARATION OF BENZIMIDAZOL THIENYLAMINE COMPOUNDS AND DERIVATIVES THEREOF USEFUL AS SODIUM/PROTON EXCHANGER TYPE 3 INHIBITORS 审中-公开制备苯并咪唑类三苯胺化合物的方法及其作为钠/原子交换剂类型3抑制剂有用的衍生物公开(公告)号：US20100174088A1
公开(公告)日：2010-07-08
申请号：US12637096
申请日：2009-12-14
申请人： Timothy Allen Ayers , Nakyen Choy , Harpal S. Gill , Andrea Hillegass , John J. Shay, JR. , Volker Derdau
发明人： Timothy Allen Ayers , Nakyen Choy , Harpal S. Gill , Andrea Hillegass , John J. Shay, JR. , Volker Derdau
IPC分类号： C07D409/12 , C07D235/04 , C07D333/04
CPC分类号： C07D409/12 , C07D333/36
摘要： The present invention is an improved process for the preparation of a sodium/proton exchange inhibitor of sub-type 3 (NHE-3) useful in the treatment of sleep apnea and other related respiratory disorders. The improved synthesis of the NHE-3 inhibitor, more specifically a benzimidazol thienylamine, utilizes novel reagents and chemical intermediates and thereby results in an improved yield and purity of the final product with less reaction or synthetic steps required
摘要翻译： 本发明是用于制备用于治疗睡眠呼吸暂停和其它相关呼吸障碍的亚型3型（NHE-3）的钠/质子交换抑制剂的改进方法。 NHE-3抑制剂，更特别是苯并咪唑噻吩胺的改进合成利用新型试剂和化学中间体，从而导致最终产物的产率和纯度提高，反应或合成步骤少
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