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    1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
    4.
    发明授权
    1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents 失效
    1,3,4-恶二唑基 - 苯氧基烷基异恶唑及其作为抗病毒剂的用途

    公开(公告)号：US5110821A

    公开(公告)日：1992-05-05

    申请号：US534917

    申请日：1990-06-07

    Applicant: Guy D. Diana

    Inventor： Guy D. Diana

    IPC: A61K31/42 ,  C07D261/08 ,  C07D413/12

    CPC classification number: C07D413/12 ,  C07D261/08

    Abstract: Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms;R' is lower-alkyl or hydroxy-lower-alkyl or 1-5 carbon atoms;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andR.sub.8 is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when R.sub.8 is hydrogen R' is hydroxy-lower-alkyl,are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.

    Abstract translation: 式IMA的化合物其中：Y是3-9个碳原子的亚烷基桥; R'是低级烷基或羟基 - 低级 - 烷基或1-5个碳原子; R 1和R 2是氢，卤素，低级烷基，低级烷氧基，硝基，低级烷氧基羰基或三氟甲基; 并且R 8为氢或1-5个碳原子的低级烷基，条件是当R 8为氢时R'为羟基 - 低级 - 烷基，可用作抗病毒剂，特别是针对小核糖核酸病毒，包括许多鼻病毒株。

    Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents
    5.
    发明授权
    Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents 失效
    噻唑基苯氧基烷基异恶唑，相关化合物及其作为抗病毒剂的用途

    公开(公告)号：US5051437A

    公开(公告)日：1991-09-24

    申请号：US395837

    申请日：1989-08-18

    Applicant: Guy D. Diana

    Inventor： Guy D. Diana

    IPC: C07D413/12 ,  C07D417/12

    CPC classification number: C07D413/12 ,  C07D417/12

    Abstract: Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms;Z is N or HC;R is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when Z is N, R is lower-alkyl;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andHet is selected from thiazole, benzothiazole and benzoxazole groups,are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.

    Abstract translation: 式IMA的化合物其中：Y是3-9个碳原子的亚烷基桥; Z是N或HC; R为氢或1-5个碳原子的低级烷基，条件是当Z为N时，R为低级烷基; R 1和R 2是氢，卤素，低级烷基，低级烷氧基，硝基，低级烷氧基羰基或三氟甲基; 和Het选自噻唑，苯并噻唑和苯并恶唑基团，可用作抗病毒剂，特别是对小核糖核酸病毒，包括许多鼻病毒株。

    1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
    6.
    发明授权
    1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents 失效
    1,2,4-恶二唑基 - 苯氧基烷基异恶唑及其作为抗病毒剂的用途

    公开(公告)号：US4942241A

    公开(公告)日：1990-07-17

    申请号：US396414

    申请日：1989-08-21

    Applicant: Guy D. Diana ,  Thomas R. Bailey

    Inventor： Guy D. Diana ,  Thomas R. Bailey

    IPC: C07D271/06 ,  C07D413/12

    CPC classification number: C07D271/06 ,  C07D413/12

    Abstract: Compounds of the formulas ##STR1## wherein: Y is an alkylene bridge of 1-9 carbon atoms;R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andR.sub.8 is hydrogen or lower-alkyl of 1-5 carbon atoms,are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.

    Abstract translation: 其中：Y是1-9个碳原子的亚烷基桥; R'是1-5个碳原子的低级烷基或羟基 - 低级 - 烷基; R 1和R 2是氢，卤素，低级烷基，低级烷氧基，硝基，低级烷氧基羰基或三氟甲基; R8是氢或1-5个碳原子的低级烷基，可用作抗病毒剂，特别是对小核糖核酸病毒，包括许多鼻病毒株。

    Isoxazoles as antiviral agents
    8.
    发明授权
    Isoxazoles as antiviral agents 失效
    异恶唑作为抗病毒剂

    公开(公告)号：US4451476A

    公开(公告)日：1984-05-29

    申请号：US542871

    申请日：1983-10-17

    Applicant: Guy D. Diana

    Inventor： Guy D. Diana

    IPC: C07D261/08 ,  A61K31/42

    CPC classification number: C07C255/00 ,  C07D261/08

    Abstract: Compounds of the formulas: ##STR1## wherein R is alkyl, X is O or CH.sub.2, n is an integer from 4 to 8, and Ar is phenyl or substituted phenyl are useful as antiviral agents especially against picornaviruses.

    Abstract translation: 下式的化合物：其中R是烷基，X是O或CH 2，n是4到8的整数，Ar是苯基或取代的苯基可用作抗病毒剂，特别是对小核糖核酸病毒。

    4-(Arylaliphatic)isoxazoles
    9.
    发明授权
    4-(Arylaliphatic)isoxazoles 失效
    4-（芳基脂肪族）异恶唑

    公开(公告)号：US4268678A

    公开(公告)日：1981-05-19

    申请号：US72134

    申请日：1979-09-04

    Applicant: Guy D. Diana ,  Philip M. Carabateas

    Inventor： Guy D. Diana ,  Philip M. Carabateas

    IPC: C07D261/08 ,  A61K31/42

    CPC classification number: C07D261/08

    Abstract: 4-(Arylaliphatic)isoxazoles, having antiviral activity, are prepared by reacting with hydroxylamine a diketone of the formula Ar-Y-CH(CO-R).sub.2, wherein Ar is substituted phenyl, Y is (CH.sub.2).sub.n or O(CH.sub.2).sub.n, and R is lower-alkyl.

    Abstract translation: 具有抗病毒活性的4-（芳基脂族）异恶唑通过与羟胺与式Ar-Y-CH（CO-R）2的二酮（其中Ar是取代的苯基，Y是（CH 2）n或O（CH 2） ）n，R为低级烷基。

    Arylalkyl and aryloxyalkyl phosphonates as antiviral agents
    10.
    发明授权
    Arylalkyl and aryloxyalkyl phosphonates as antiviral agents 失效
    芳基烷基和芳氧基烷基膦酸酯作为抗病毒剂

    公开(公告)号：US4217346A

    公开(公告)日：1980-08-12

    申请号：US27257

    申请日：1979-04-05

    Applicant: Guy D. Diana

    Inventor： Guy D. Diana

    IPC: C07F9/40 ,  A61K31/66

    CPC classification number: C07F9/4056 ,  C07F9/4006

    Abstract: Arylalkyl and aryloxyalkylphosphonates, useful as antiviral agents, are prepared by reacting an arylalkyl or aryloxyalkyl halide with a trialkyl phosphite, or with an alkali metal salt of a dialkyl phosphonate, trialkyl phosphonoalkanoate or dialkyl phosphonoalkanone.

    Abstract translation: 可用作抗病毒剂的芳基烷基和芳氧基烷基膦酸盐通过芳基烷基或芳氧基烷基卤化物与亚磷酸三烷基酯或与膦酸二烷基酯的三烷基膦酸烷基酯或二烷基膦酰基烷酮的碱金属盐反应来制备。

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