公开(公告)号：US07648709B2

公开(公告)日：2010-01-19

申请号：US10513493

申请日：2003-05-08

申请人： Miriam de San Juan Bosco Lastre González ,  Oliver Germán Pérez Martín ,  Alexis Labrada Rosado ,  Igor Bidot Martínez ,  Gustavo Rafael Bracho Granado ,  Judith Mónica Del Campo Alonso ,  Dainerys Aleida Pérez Lastre ,  Elisa Facenda Ramos ,  Caridad Zayas Vignier ,  Claudio Rodríguez Martínez ,  Victoriano Gustavo Sierra González ,  Jorge Ernesto Pérez Lastre

发明人： Miriam de San Juan Bosco Lastre González ,  Oliver Germán Pérez Martín ,  Alexis Labrada Rosado ,  Igor Bidot Martínez ,  Gustavo Rafael Bracho Granado ,  Judith Mónica Del Campo Alonso ,  Dainerys Aleida Pérez Lastre ,  Elisa Facenda Ramos ,  Caridad Zayas Vignier ,  Claudio Rodríguez Martínez ,  Victoriano Gustavo Sierra González ,  Jorge Ernesto Pérez Lastre

IPC分类号： A61K39/095 ,  A61K39/35

CPC分类号： A61K39/35 ,  A61K2039/55505 ,  A61K2039/55583 ,  A61K2039/55594 ,  A61K2039/57 ,  A61K2039/6018

摘要： The present invention relates to the field of Immunology, specifically with the branch of Immuno-Allergy and in particular with the use of adjuvant or carrier compounds, capable of modulating the immune response to allergens. The technical objective that is pursued is to obtain a pharmaceutical preparation of therapeutic or prophylactic use using bacterial proteoliposomes, which transform the allergic response Th2 and IgE when being applied in allergic individuals, toward a protector response Th1; as well as it is able to prevent the appearance and the development of allergies in individuals non-allergic yet. The vaccine composition consists of proteoliposomes derived from Gram-negative bacteria coupled to allergens and optionally contains other adjuvants or antigens. The method for its preparation and an immunization scheme of two doses are provided.

摘要翻译： 本发明涉及免疫学领域，特别是与免疫过敏的分支，特别涉及能够调节对变应原的免疫应答的佐剂或载体化合物的使用。 所追求的技术目标是使用细菌蛋白脂质体获得治疗或预防用药的药物制剂，其在过敏性个体中应用时将变应原反应Th2和IgE转变为保护剂应答Th1; 以及它能够防止个人的过敏症的出现和发展也不过敏。 疫苗组合物由衍生自与变应原偶联的革兰氏阴性细菌的蛋白脂质体组成，并任选地含有其它佐剂或抗原。 提供了其制备方法和两种剂量的免疫方案。