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18 条记录 (耗时 0.021 秒)

    Compositions and methods for reducing inflammation
    1.
    发明授权
    Compositions and methods for reducing inflammation 有权
    减轻炎症的组合物和方法

    公开(公告)号：US09370537B2

    公开(公告)日：2016-06-21

    申请号：US13259405

    申请日：2010-04-02

    申请人： Gitte S. Jensen

    发明人： Gitte S. Jensen

    IPC分类号： A61K35/748 ,  A61K35/74

    CPC分类号： A61K35/74 ,  A61K35/748

    摘要： Blue-green algae, such as Aphanizomenon flos aquae (AFA) or Spirulina (Arthrospira) can be fractionated. Anti-inflammatory aqueous fractions of blue-green algae are described herein that include low molecular weight molecules. Methods for reducing inflammation in a subject are also described. These methods include administering to the subject compositions comprising a therapeutically effective amount of the anti-inflammatory aqueous fraction blue-green algae, or dried form thereof, thereby reducing inflammation.

    摘要翻译： 可以分离蓝绿色藻类，如Aphanizomenon flos aquae（AFA）或螺旋藻（Arthrospira）。 本文描述了蓝绿色藻类的抗炎水性级分，其包括低分子量分子。 还描述了减少受试者中炎症的方法。 这些方法包括对包含治疗有效量的抗炎水性级分蓝绿色藻类或其干燥形式的受试者组合物施用，从而减少炎症。

    CELL-BASED ANTIOXIDANT PROTECTION ASSAY
    4.
    发明申请
    CELL-BASED ANTIOXIDANT PROTECTION ASSAY 有权
    基于细胞的抗氧化剂保护测定

    公开(公告)号：US20130260418A1

    公开(公告)日：2013-10-03

    申请号：US13902556

    申请日：2013-05-24

    申请人： Gitte S. Jensen

    发明人： Gitte S. Jensen

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6486 ,  G01N33/5014 ,  G01N33/52 ,  Y10T436/105831 ,  Y10T436/13 ,  Y10T436/25125 ,  Y10T436/25375

    摘要： Methods are provided herein for determining antioxidant activity of a test sample in intact cells. The method includes determining the antioxidant capacity of a test sample in intact red blood cells, wherein the test sample is added to intact red blood cells and oxidative damage is measured by alteration of fluorescence intensity of an oxidation-sensitive fluorescent indicator dye.

    摘要翻译： 本文提供了用于测定完整细胞中测试样品的抗氧化活性的方法。 该方法包括确定完整红细胞中测试样品的抗氧化能力，其中将测试样品加入到完整的红细胞中，氧化损伤通过氧化敏感荧光指示剂染料的荧光强度的改变来测量。

    Purified component of blue-green algae and method of use
    5.
    发明授权
    Purified component of blue-green algae and method of use 有权
    蓝藻的净化成分和使用方法

    公开(公告)号：US07947284B2

    公开(公告)日：2011-05-24

    申请号：US12636653

    申请日：2009-12-11

    申请人： Gitte S. Jensen ,  Christian Drapeau

    发明人： Gitte S. Jensen ,  Christian Drapeau

    IPC分类号： A61K36/02

    CPC分类号： A61K35/748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/195

    摘要： Disclosed herein are extracts of blue green algae, such as Aphanizomenon flos aquae, that are enriched for a selectin ligand, such as an L-selectin ligand. Selectin ligands isolated from blue-green algae cells are disclosed herein. Methods are described for isolating these selectin ligands. The purified selectin ligands are of use in inducing stem cell mobilization in a subject. Thus, methods for inducing stem cell isolation that include administering a therapeutically effective amount of the extract enriched form the selectin ligand, or an isolated selectin ligand, are disclosed herein.

    摘要翻译： 本文公开了富集选择素配体例如L-选择蛋白配体的蓝绿色藻类（例如Aphanizomenon flos aquae）的提取物。 本文公开了从蓝绿藻细胞分离的选择素配体。 描述了分离这些选择蛋白配体的方法。 纯化的选择蛋白配体可用于诱导受试者的干细胞移动。 因此，本文公开了诱导干细胞分离的方法，包括施用治疗有效量的选自蛋白配体富集的提取物或分离的选择蛋白配体。

    Methods and compositions for enhancing stem cell mobilization
    6.
    发明授权
    Methods and compositions for enhancing stem cell mobilization 有权

    公开(公告)号：US10159705B2

    公开(公告)日：2018-12-25

    申请号：US13807097

    申请日：2011-06-28

    申请人： Christian Drapeau ,  Gitte S. Jensen

    发明人： Christian Drapeau ,  Gitte S. Jensen

    IPC分类号： A61K36/81 ,  A61K36/07 ,  A61K35/20 ,  A61K36/074 ,  A61K36/02 ,  A61K36/06 ,  A61K36/03 ,  A61K36/068 ,  A61K36/815 ,  A61K31/737 ,  A61K35/748

    摘要： A method of using fucoidan to enhance stem cell mobilization in a subject, including hematopoietic stem cells (HSCs) and bone marrow stem cells (BMSCs) is provided. In the method, a blended composition of fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote trafficking of stem cells, resulting in migration of the stem cells to specific sties of maintenance an and repair within tissues and/or organs. The method also involves the use of fucoidan obtained from particular algae species to support release and circulation of HSCs, as demonstrated by significantly increase circulation of HSCs in the peripheral blood. Increased circulation of HSCs and/or BMSCs and migration towards sites of maintenance and the natural regeneration mechanisms in the body. Further provided is a dosing regimen for the administration of fucoidan and a method of enhancing release and circulation of stem cells.

    Method for enhancing stem cell trafficking
    7.
    发明授权
    Method for enhancing stem cell trafficking 有权
    增强干细胞运输的方法

    公开(公告)号：US08034328B2

    公开(公告)日：2011-10-11

    申请号：US12033801

    申请日：2008-02-19

    申请人： Gitte S. Jensen ,  Christian Drapeau

    发明人： Gitte S. Jensen ,  Christian Drapeau

    IPC分类号： A01N63/00 ,  A01N63/02 ,  C12N1/12

    CPC分类号： A61K35/748 ,  Y10S435/946

    摘要： Consumption of blue-green algae, or extracts thereof, enhances trafficking or homing of stem cells in animals by inducing a transient increase in the population of stem cells present in the animal's circulatory system. The animal may be healthy or suffering some disease or physiological condition.

    摘要翻译： 通过诱导存在于动物循环系统中的干细胞群体的瞬时增加，蓝绿藻或其提取物的消耗增加了动物中干细胞的运输或归巢。 动物可能健康或患有某种疾病或生理状况。

    PURIFIED COMPONENT OF BLUE-GREEN ALGAE AND METHOD OF USE
    8.
    发明申请
    PURIFIED COMPONENT OF BLUE-GREEN ALGAE AND METHOD OF USE 有权

    公开(公告)号：US20100092507A1

    公开(公告)日：2010-04-15

    申请号：US12636653

    申请日：2009-12-11

    申请人： Gitte S. Jensen ,  Christian Drapeau

    发明人： Gitte S. Jensen ,  Christian Drapeau

    IPC分类号： A61K36/02 ,  A61P25/28

    CPC分类号： A61K35/748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/195

    摘要： Disclosed herein are extracts of blue green algae, such as Aphanizomenon flos aquae, that are enriched for a selectin ligand, such as an L-selectin ligand. Selectin ligands isolated from blue-green algae cells are disclosed herein. Methods are described for isolating these selectin ligands. The purified selectin ligands are of use in inducing stem cell mobilization in a subject. Thus, methods for inducing stem cell isolation that include administering a therapeutically effective amount of the extract enriched form the selectin ligand, or an isolated selectin ligand, are disclosed herein.

    Method for enhancing stem cell trafficking
    10.
    发明授权
    Method for enhancing stem cell trafficking 有权
    增强干细胞运输的方法

    公开(公告)号：US06814961B1

    公开(公告)日：2004-11-09

    申请号：US10145081

    申请日：2002-05-13

    申请人： Gitte S. Jensen ,  Christian Drapeau

    发明人： Gitte S. Jensen ,  Christian Drapeau

    IPC分类号： A01N6300

    CPC分类号： A61K35/748 ,  Y10S435/946

    摘要： Consumption of blue-green algae, or extracts thereof, enhances trafficking or homing of stem cells in animals by inducing a transient increase in the population of stem cells present in the animal's circulatory system. The animal may be healthy or suffering some disease or physiological condition.

    摘要翻译： 通过诱导存在于动物循环系统中的干细胞群体的瞬时增加，蓝绿藻或其提取物的消耗增加了动物中干细胞的运输或归巢。 动物可能健康或患有某种疾病或生理状况。