公开(公告)号：US20240398783A1

公开(公告)日：2024-12-05

申请号：US18688859

申请日：2022-09-06

Applicant: Gismo Therapeutics, Inc.

Inventor： Paul GREGOR ,  Myung Hee KIM ,  Brian MARRON

IPC: A61K31/4709 ,  A61K31/4164 ,  A61K31/4706 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D215/42 ,  C07D233/64 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14

Abstract: The disclosure provides quinoline and quinazoline derivative compounds and pharmaceutical compositions thereof. These compounds inhibit the interactions between GAG-binding amyloid peptides (GBAPs) and heparan sulfate glycosaminoglycans (HS-GAGs) and thus may be useful as therapeutics for the treatment and prevention of neurodegenerative diseases associated with amyloidosis, for example Alzheimer's Disease, and for other amyloid disorders. The present disclosure further provides methods of treatment and prevention of neurodegenerative and amyloid diseases, and methods for identifying small organic molecule compounds that can inhibit the interaction of glycosaminoglycans (GAGs) with GAG-binding amyloid peptides (GBAPs).