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公开(公告)号：US20110140298A1
公开(公告)日：2011-06-16
申请号：US12941314
申请日：2010-11-08
申请人： Giovanni POLITI , Erkki HEILAKKA
发明人： Giovanni POLITI , Erkki HEILAKKA
IPC分类号： B29C43/34
CPC分类号： A61K9/2095 , A61J3/10 , A61K31/155 , A61K31/167 , A61K31/192 , B01J2/22 , B07B1/24 , B07B4/02 , B07B4/08 , B07B7/04 , B07B7/06 , B07B7/086 , B29B9/12 , B29L2031/00
摘要： The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
摘要翻译： 本发明尤其提供了一种从粉末中制备颗粒的方法，其特征在于，将压实力施加到粉末上以产生包含细颗粒和颗粒的混合物的压块，并分离和除去细颗粒和/或小颗粒 通过夹带气流中的细颗粒和/或小颗粒从其它颗粒中除去。 还提供了用于该方法的装置和通过压缩所得颗粒形成的片剂。
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公开(公告)号：US20080111269A1
公开(公告)日：2008-05-15
申请号：US11979530
申请日：2007-11-05
申请人： Giovanni Politi , Erkki Heilakka
发明人： Giovanni Politi , Erkki Heilakka
CPC分类号： B01J2/22 , A61J3/10 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/209 , A61K9/2095 , B03C7/06
摘要： The invention provides, inter alia, a method for producing granules from a powder, characterized in that a low compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating fine particles from the granules by entraining the fine particles in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
摘要翻译： 本发明尤其提供了一种从粉末制造颗粒的方法，其特征在于，将低压实力施加到粉末上以产生包含细颗粒和颗粒的混合物的压块，并通过夹带从颗粒中分离细颗粒 气流中的细颗粒。 还提供了用于该方法的装置和通过压缩所得颗粒形成的片剂。
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公开(公告)号：US08951562B2
公开(公告)日：2015-02-10
申请号：US12941314
申请日：2010-11-08
申请人： Giovanni Politi , Erkki Heilakka
发明人： Giovanni Politi , Erkki Heilakka
IPC分类号： A61K9/14 , A61K9/22 , B07B7/086 , A61K9/20 , B01J2/22 , B07B1/24 , B07B4/02 , B07B4/08 , B07B7/04 , B07B7/06 , A61J3/10
CPC分类号： A61K9/2095 , A61J3/10 , A61K31/155 , A61K31/167 , A61K31/192 , B01J2/22 , B07B1/24 , B07B4/02 , B07B4/08 , B07B7/04 , B07B7/06 , B07B7/086 , B29B9/12 , B29L2031/00
摘要： The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
摘要翻译： 本发明尤其提供了一种从粉末中制备颗粒的方法，其特征在于，将压实力施加到粉末上以产生包含细颗粒和颗粒的混合物的压块，并分离和除去细颗粒和/或小颗粒 通过夹带气流中的细颗粒和/或小颗粒从其它颗粒中除去。 还提供了用于该方法的装置和通过压缩所得颗粒形成的片剂。
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公开(公告)号：US08590818B2
公开(公告)日：2013-11-26
申请号：US13127865
申请日：2009-11-04
申请人： Giovanni Politi
发明人： Giovanni Politi
摘要： An apparatus wherein the gas enters from an opening 4 located in a part of a compaction chamber 3 and is dragged through a granulator 5, a fractioning device 12, a special cyclone 11 and a filter system 8A to a suction fan, which creates a gas stream. In such apparatus the bulk to be compacted 1, the fine particles to be compacted again and the compacted bulk have the same flow direction than the carrier gas. Due to its complete or partial impermeability, the structure of the apparatus makes also possible the use of a gas different from normal air. This is important when the bulk is sensible to oxygen.
摘要翻译： 一种装置，其中气体从位于压实室3的一部分的开口4进入，并且通过造粒机5，分馏装置12，特殊旋风分离器11和过滤器系统8A拖到吸风机上，从而产生气体 流。 在这种装置中，要压实的体积1，再次压实的细颗粒和压实块体具有与载气相同的流动方向。 由于其完全或部分不可渗透性，装置的结构也可能使用与正常空气不同的气体。 当体积对氧气敏感时，这很重要。
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公开(公告)号：US20060222703A1
公开(公告)日：2006-10-05
申请号：US11097969
申请日：2005-04-01
申请人： Giovanni Politi
发明人： Giovanni Politi
IPC分类号： A61K31/198 , B27N3/00 , A61K9/20
CPC分类号： A61K9/2077 , A61K9/1652 , A61K9/2013 , A61K9/2054 , A61K9/2059 , A61K31/198
摘要： The invention relates to an oral solid pharmaceutical composition comprising pharmacologically effective amounts of entacapone, levodopa and carbidopa, or a pharmaceutically acceptable salt or hydrate thereof, and one or more pharmaceutically acceptable excipients, wherein the excipients are long-chain polymers having an equilibrium moisture content of at least 2%, and to a preparation method thereof. The compositions can be used for the treatment of Parkinson's disease.
摘要翻译： 本发明涉及包含药理学有效量的恩他卡朋，左旋多巴和卡比多巴或其药学上可接受的盐或水合物以及一种或多种药学上可接受的赋形剂的口服固体药物组合物，其中所述赋形剂是具有平衡含水量的长链聚合物 至少为2％，及其制备方法。 该组合物可用于治疗帕金森病。
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公开(公告)号：US08581134B2
公开(公告)日：2013-11-12
申请号：US12580558
申请日：2009-10-16
申请人： Giovanni Politi , Erkki Heilakka
发明人： Giovanni Politi , Erkki Heilakka
摘要： The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
摘要翻译： 本发明尤其提供了一种从粉末中制备颗粒的方法，其特征在于，将压实力施加到粉末上以产生包含细颗粒和颗粒的混合物的压块，并分离和除去细颗粒和/或小颗粒 通过夹带气流中的细颗粒和/或小颗粒从其它颗粒中除去。 还提供了用于该方法的装置和通过压缩所得颗粒形成的片剂。
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公开(公告)号：US08052999B2
公开(公告)日：2011-11-08
申请号：US11979530
申请日：2007-11-05
申请人： Giovanni Politi , Erkki Heilakka
发明人： Giovanni Politi , Erkki Heilakka
CPC分类号： B01J2/22 , A61J3/10 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/209 , A61K9/2095 , B03C7/06
摘要： The invention provides, inter alia, a method for producing granules from a powder, characterized in that a low compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating fine particles from the granules by entraining the fine particles in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
摘要翻译： 本发明尤其提供了一种从粉末制造颗粒的方法，其特征在于，将低压实力施加到粉末上以产生包含细颗粒和颗粒的混合物的压块，并通过夹带从颗粒中分离细颗粒 气流中的细颗粒。 还提供了用于该方法的装置和通过压缩所得颗粒形成的片剂。
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公开(公告)号：US20110220745A1
公开(公告)日：2011-09-15
申请号：US13127865
申请日：2009-11-04
申请人： Giovanni Politi
发明人： Giovanni Politi
IPC分类号： B02C23/24
摘要： An apparatus wherein the gas enters from an opening 4 located in a part of a compaction chamber 3 and is dragged through a granulator 5, a fractioning device 12, a special cyclone 11 and a filter system 8A to a suction fan, which creates a gas stream. In such apparatus the bulk to be compacted 1, the fine particles to be compacted again and the compacted bulk have the same flow direction than the carrier gas. Due to its complete or partial impermeability, the structure of the apparatus makes also possible the use of a gas different from normal air. This is important when the bulk is sensible to oxygen.
摘要翻译： 一种装置，其中气体从位于压实室3的一部分的开口4进入，并且通过造粒机5，分馏装置12，特殊旋风分离器11和过滤器系统8A拖到吸风机上，从而产生气体 流。 在这种装置中，要压实的体积1，再次压实的细颗粒和压实块体具有与载气相同的流动方向。 由于其完全或部分不可渗透性，装置的结构也可能使用与正常空气不同的气体。 当体积对氧气敏感时，这很重要。
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公开(公告)号：US20110089087A1
公开(公告)日：2011-04-21
申请号：US12977332
申请日：2010-12-23
申请人： Giovanni POLITI , Erkki Heilakka
发明人： Giovanni POLITI , Erkki Heilakka
IPC分类号： B07B7/06
CPC分类号： B01J2/22 , A61J3/10 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/209 , A61K9/2095 , B03C7/06
摘要： The invention provides, inter alia, a method for producing granules from a powder, characterized in that a low compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating fine particles from the granules by entraining the fine particles in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
摘要翻译： 本发明尤其提供了一种从粉末制造颗粒的方法，其特征在于，将低压实力施加到粉末上以产生包含细颗粒和颗粒的混合物的压块，并通过夹带从颗粒中分离细颗粒 气流中的细颗粒。 还提供了用于该方法的装置和通过压缩所得颗粒形成的片剂。
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公开(公告)号：US20100184861A1
公开(公告)日：2010-07-22
申请号：US12580558
申请日：2009-10-16
申请人： Giovanni Politi , Erkki Heilakka
发明人： Giovanni Politi , Erkki Heilakka
IPC分类号： A61K31/192 , A61K31/167 , A61K31/138 , A61K31/155 , B07B4/00 , B07B9/00
摘要： The invention provides, inter alia, a method for producing granules from a powder, characterized in that compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the other granules by entraining the fine particles and/or small granules in a gas stream. Also provided are apparatus for use in the process and tablets formed by compression of the resultant granules.
摘要翻译： 本发明尤其提供了一种从粉末中制备颗粒的方法，其特征在于，将压实力施加到粉末上以产生包含细颗粒和颗粒的混合物的压块，并分离和除去细颗粒和/或小颗粒 通过夹带气流中的细颗粒和/或小颗粒从其它颗粒中除去。 还提供了用于该方法的装置和通过压缩所得颗粒形成的片剂。
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