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    ISOTOPICALLY MARKED QUINOLINE DERIVATIVES AS ADENOSIN A3 RECEPTOR LIGANDS
    3.
    发明申请
    ISOTOPICALLY MARKED QUINOLINE DERIVATIVES AS ADENOSIN A3 RECEPTOR LIGANDS 失效
    同位素标记的喹啉衍生物作为腺苷A3受体配体

    公开(公告)号：US20080027225A1

    公开(公告)日：2008-01-31

    申请号：US11748098

    申请日：2007-05-14

    Applicant: Geza Timari ,  Kinga Boer ,  Geza Toth ,  Csaba Tomboly

    Inventor： Geza Timari ,  Kinga Boer ,  Geza Toth ,  Csaba Tomboly

    IPC: C07D215/42

    CPC classification number: C07D409/12 ,  A61K51/0455 ,  C07D215/54 ,  C07F7/2208

    Abstract: The invention relates to adenozin A3 receptor ligands labeled with iodine isotops of mass number 125, within those favourably to antagonists and their isomers, to the experimental materials containing them, to a process for the preparation of the compounds of the general formula (I) and their isomers, to the new intermediates of the general formula (II) and to the preparation thereof.

    Abstract translation: 本发明涉及使用质量数为125的碘异构体标记的腺苷A 3 N 3受体配体，其中有益于拮抗剂及其异构体，含有它们的实验材料，涉及制备化合物的方法 通式（I）的化合物及其异构体与通式（II）的新中间体及其制备方法。

    Isotopically marked quinoline derivatives as adenosin A3 receptor ligands
    5.
    发明授权
    Isotopically marked quinoline derivatives as adenosin A3 receptor ligands 失效
    同位素标记喹啉衍生物作为腺苷A3受体配体

    公开(公告)号：US07964731B2

    公开(公告)日：2011-06-21

    申请号：US11748098

    申请日：2007-05-14

    Applicant: Geza Timari ,  Kinga Boer ,  Geza Toth ,  Csaba Tomboly

    Inventor： Geza Timari ,  Kinga Boer ,  Geza Toth ,  Csaba Tomboly

    IPC: C07D215/38

    CPC classification number: C07D409/12 ,  A61K51/0455 ,  C07D215/54 ,  C07F7/2208

    Abstract: The invention relates to adenozin A3 receptor ligands labeled with iodine isotops of mass number 125, within those favorably to antagonists and their isomers, to the experimental materials containing them, to a process for the preparation of the compounds of the general formula (I) and their isomers, to the new intermediates of the general formula (II) and to the preparation thereof.

    Abstract translation: 本发明涉及通过质量数为125的碘异构体标记的腺苷A3受体配体，其中有益于拮抗剂及其异构体，含有它们的实验材料，涉及制备通式（I）的化合物和 它们的异构体，通式（II）的新中间体及其制备。

    Process for the preparation of carbamate derivatives
    7.
    发明授权
    Process for the preparation of carbamate derivatives 失效
    制备氨基甲酸酯衍生物的方法

    公开(公告)号：US4086246A

    公开(公告)日：1978-04-25

    申请号：US682033

    申请日：1976-04-30

    Applicant: Geza Toth ,  Istvan Toth ,  Tibor Montay

    Inventor： Geza Toth ,  Istvan Toth ,  Tibor Montay

    IPC: C07C275/30 ,  C07C67/00 ,  C07C239/00 ,  C07C271/08 ,  C07C273/02 ,  C07C273/18 ,  C07C275/40 ,  C07D235/32 ,  C07D277/28 ,  C07D307/86 ,  C07D317/24 ,  C07D307/87

    CPC classification number: C07D235/32 ,  C07C273/1809 ,  C07D307/86 ,  C07D317/24

    Abstract: A process for the preparation of a compound of the formula: ##STR1## wherein R.sup.1 is alkyl, alkyl substituted by halogen, alkyl substituted by alkoxy, aryl, aryl substituted by halogen, aryl substituted by alkyl, aryl substituted by alkoxy, aralkyl, aralkyl substituted by alkoxy, cycloalkyl, cycloalkyl substituted by halogen, cycloalkyl substituted by alkyl or cycloalkyl substituted by alkoxy, andR.sup.2 is an aromatic group, an aromatic group substituted by alkyl, an aromatic group substituted by halogen, an aromatic group substituted by alkoxy, a heteroaromatic group, a heteroaromatic group substituted by alkyl, a heteroaromatic group substituted by halogen, or a heteroaromatic group substituted by alkoxy, by the reaction of phosgene with a phenol of the formula:R.sup.2 -OHand further by the reaction of a primary amine of the formula:R'--NH.sub.2,reacting all three of the abovementioned reactants solution in a common water-immiscible organic solvent in the same reaction vessel at the same time in the presence of an acid binding agent to yield the compound of formula ##STR2##

    Abstract translation: 一种制备下式化合物的方法：其中R1是烷基，被卤素取代的烷基，被烷氧基取代的烷基，芳基，被卤素取代的芳基，被烷基取代的芳基，被烷氧基取代的芳基，芳烷基，芳烷基 被烷氧基取代的环烷基，被烷基取代的环烷基或被烷氧基取代的环烷基，R2是芳基，被烷基取代的芳基，被卤素取代的芳基，被烷氧基取代的芳基， 杂芳基，被烷基取代的杂芳基，被卤素取代的杂芳基或被烷氧基取代的杂芳基，通过光气与下式的苯酚反应：

    Process for the preparation of polyhalogenphenyl carbamates
    10.
    发明授权
    Process for the preparation of polyhalogenphenyl carbamates 失效
    制备多卤代苯基氨基甲酸酯的方法

    公开(公告)号：US4347377A

    公开(公告)日：1982-08-31

    申请号：US188966

    申请日：1980-09-19

    Applicant: Istvan Bitter ,  Rudolf Soos ,  Geza Toth ,  Laszlo Toke ,  Gabor Szabo

    Inventor： Istvan Bitter ,  Rudolf Soos ,  Geza Toth ,  Laszlo Toke ,  Gabor Szabo

    IPC: C07C271/08 ,  C07C67/00 ,  C07C239/00 ,  C07C257/08 ,  C07C271/06 ,  C07C125/067

    CPC classification number: C07C271/06

    Abstract: The invention concerns a new process for the preparation of polyhalogenphenyl carbamates of the formula (I)R.sup.2 -OCONHR.sup.1 (I)whereinR.sup.1 is alkyl, aralkyl or aryl, where the aromatic rings may optionally be substituted; andR.sup.2 is phenyl substituted with three, four or five halogens, through intermediates of the formula (IV)(R.sup.2 --O).sub.2 C.dbd.NR.sup.1 (IV)wherein R.sup.1 and R.sup.2 are as defined above.The compounds of the formula (I) are valuable acylating agents. The intermediates of the formula (IV) are new compounds, which are also encompassed by the invention.

    Abstract translation: 本发明涉及一种制备式（I）的多卤代苯基氨基甲酸酯的新方法，其中R 1为烷基，芳烷基或芳基，其中芳环可任选被取代; R2为通过式（IV）中间体（R2-O）2C = NR1（Ⅳ）取代的苯基，其中R1和R2如上定义。 式（I）的化合物是有价值的酰化剂。 式（IV）的中间体是新化合物，其也包括在本发明中。

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