公开(公告)号：US08923955B2

公开(公告)日：2014-12-30

申请号：US12377819

申请日：2007-08-16

Applicant: Luc Thiberville ,  Charlotte Cave ,  Véronique Dentan ,  Nicolas Boularot ,  Geneviève Bourg-Heckly ,  Eric Peltier

Inventor： Luc Thiberville ,  Charlotte Cave ,  Véronique Dentan ,  Nicolas Boularot ,  Geneviève Bourg-Heckly ,  Eric Peltier

IPC: A61B6/00 ,  A61B1/267 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B1/00 ,  A61B1/018

CPC classification number: A61B1/2676 ,  A61B1/00165 ,  A61B1/018 ,  A61B1/043 ,  A61B1/2736 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

Abstract: A method for imaging a tissue includes collecting a light signal from at least part of said tissue, using a fiber optic probe for fluorescence imaging, wherein the fiber optic probe comprises a plurality of optic fibers, and wherein a distal tip of the fiber optic probe is placed at a distance from said tissue, said imaging being made confocal at a proximal tip of said fiber optic probe. A fluorescence imaging system includes an endoscope equipped with a working channel, in which a fiber optic probe has been inserted, wherein the fiber optic probe is movable between a retracted position and at least one position of extension, said fiber optic probe comprising a plurality of optic fibers for performing imaging of a tissue, said imaging being confocal via a processor located at a proximal tip of said fiber optic probe.

Abstract translation: 用于成像组织的方法包括使用用于荧光成像的光纤探针收集来自所述组织的至少一部分的光信号，其中所述光纤探针包括多个光纤，并且其中所述光纤探针的远端 被放置在离所述组织一定距离处，所述成像在所述光纤探针的近端被共焦。 荧光成像系统包括配备有工作通道的内窥镜，其中插入了光纤探针，其中光纤探头可在缩回位置和至少一个延伸位置之间移动，所述光纤探头包括多个 用于执行组织成像的光纤，所述成像通过位于所述光纤探针的近端处的处理器共焦。

公开(公告)号：US07336990B2

公开(公告)日：2008-02-26

申请号：US10500162

申请日：2002-12-20

Applicant: Magalie Genet ,  Geneviève Bourg-Heckly ,  Sandrine Vilette ,  François Lacombe ,  Alexandre Loiseau ,  Benjamin Abrat

Inventor： Magalie Genet ,  Geneviève Bourg-Heckly ,  Sandrine Vilette ,  François Lacombe ,  Alexandre Loiseau ,  Benjamin Abrat

IPC: A61B6/00

CPC classification number: G01N21/6486 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  G01N21/6456

Abstract: An equipment includes an excitation source (1), elements for injecting (2) an excitation signal produced by the source in an ordered bundle (3) of flexible optical fibers, elements for analyzing (21, 22) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle (3) an optical head (4) designed to be placed in contact with the biological tissue (6), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle (3) to converge into a subsurface analyzing zone (5), the same optical fiber(s) used for excitation of the bundle (3) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements (2) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

Abstract translation: 一种设备包括激励源（1），用于注入（2）由柔性光纤的有序束（3）中的源产生的激励信号的元件，用于分析（21,22）发射的自发荧光信号的元件。 所述设备还包括在所述光纤束（3）的输出端处设计成与所述生物组织（6）接触的光学头（4），所述光学头装备有适于使所述激发信号输出 从束（3）收敛到地下分析区（5）中，用于激发束（3）的相同光纤用于检测由地下分析区发出的信号，元件（D） 放置在注入元件（2）的上游的进一步提供以分离激发信号的波长和自发荧光信号的波长。