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    Aniline type compounds
    1.
    发明授权
    Aniline type compounds 有权
    苯胺型化合物

    公开(公告)号：US09006485B2

    公开(公告)日：2015-04-14

    申请号：US14236362

    申请日：2012-08-10

    申请人： Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frasetto ,  Gemma Veitch ,  Markus Kordes ,  Marco Naujok

    发明人： Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frasetto ,  Gemma Veitch ,  Markus Kordes ,  Marco Naujok

    IPC分类号： C07C313/00 ,  A01N41/12 ,  A01N43/50 ,  A01N43/56 ,  A01N43/80 ,  C07D401/04 ,  C07C381/10 ,  C07D401/14 ,  C07D413/14 ,  C07D409/14 ,  A01N37/28

    CPC分类号： A01N43/56 ,  A01N37/28 ,  A01N41/12 ,  A01N43/50 ,  A01N43/80 ,  C07B2200/13 ,  C07C381/10 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

    摘要： The present invention relates to compounds of the formula (I) wherein R1 and R2 independently of one another are hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C10-cycloalkyl, C3-C10-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl or together represent an aliphatic chain, or the like; R3 is halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C8-alkenyl, C2-C8-haloalkenyl, C1-C8-alkoxy, phenyl, or the like; R4 is hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl, phenyl, or the like; t is 0 or 1; p is 0, 1, 2, 3 or 4. The present invention also relates to a process for preparing a compound of the formula (I) which comprises reacting a compound of the formula II with a compound of the formulae III or IV: where t, p, R1 R3, R3 and R4 are as defined in any of claims 1 to 6 and where A− is an equivalent of an anion having a pKB of at least 10 (determined under standard conditions in water).

    摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 2彼此独立地是氢，C 1 -C 10 - 烷基，C 1 -C 10 - 卤代烷基，C 3 -C 10 - 环烷基，C 3 -C 10 - 卤代环烷基，C 2 -C 10 烯基，C 2 -C 10 - 卤代链烯基或一起代表脂族链等; R3是卤素，氰基，C1-C8-烷基，C1-C8-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C8-烯基，C2-C8-卤代烯基，C1-C8-烷氧基，苯基， 或类似物; R4是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基，苯基等; t为0或1; 本发明还涉及制备式（I）化合物的方法，其包括使式II化合物与式III或IV化合物反应：其中 t，p，R 1，R 3，R 3和R 4如权利要求1至6中任一项所定义，其中A-是pKB为至少10（在水中标准条件下测定）的阴离子的当量。

    Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds
    5.
    发明授权
    Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds 有权
    制备N-取代的1H-吡唑-5-碳酰氯化合物的方法

    公开(公告)号：US08921567B2

    公开(公告)日：2014-12-30

    申请号：US14235556

    申请日：2012-08-10

    申请人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

    发明人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04

    摘要： The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carbonylchloride compound of the formula (I) in which R1 is hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, C1-C4-fluoroalkoxy-C1-C4-alkyl, phenyl and the like; each R2 is independently selected from halogen, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, phenyl and the like; r is 0, 1, 2, 3 or 4; comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined above, with a base selected from lithium-organic base having a carbon or nitrogen bound lithium or with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a chlorocarbonylation by reacting it with a reagent selected from the group consisting of phosgene or a phosgene equivalent, to obtain a compound of formula (I).

    摘要翻译： 本发明涉及制备式（I）的N-取代的1H-吡唑-5-碳酰氯化合物的方法，其中R1是氢，卤素，氰基，C1-C6-烷基，C1-C6-氟烷基，C3 C 1-8 - 环烷基，C 3 -C 8 - 氟代环烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 氟烯基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 氟烷氧基，C 1 -C 4 - 氟烷氧基-C 1 -C 4烷基，苯基和 喜欢; 每个R 2独立地选自卤素，C 1 -C 6 - 烷基，C 1 -C 6 - 氟代烷基，C 3 -C 8 - 环烷基，C 3 -C 8 - 氟代环烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 氟烯基，C 1 -C 6烷氧基， 苯基等; r为0,1,2,3或4; 包括以下步骤：i）将其中变量R1，R2和r各自如上定义的式（II）化合物与选自具有碳或氮键合的锂的锂基或与镁结合的碱的碱 具有碳结合镁的无机碱; 和ii）通过使步骤（i）中获得的产物与选自光气或光气当量的试剂反应来进行氯羰化反应，得到式（I）化合物。

    Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds
    8.
    发明申请
    Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds 有权

    公开(公告)号：US20140163234A1

    公开(公告)日：2014-06-12

    申请号：US14235556

    申请日：2012-08-10

    申请人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

    发明人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04

    摘要： The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carbonylchloride compound of the formula (I) in which R1 is hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, C1-C4-fluoroalkoxy-C1-C4-alkyl, phenyl and the like; each R2 is independently selected from halogen, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, phenyl and the like; r is 0, 1, 2, 3 or 4; comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined above, with a base selected from lithium-organic base having a carbon or nitrogen bound lithium or with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a chlorocarbonylation by reacting it with a reagent selected from the group consisting of phosgene or a phosgene equivalent, to obtain a compound of formula (I).

    Aniline Type Compounds
    10.
    发明申请
    Aniline Type Compounds 有权
    苯胺类化合物

    公开(公告)号：US20140155451A1

    公开(公告)日：2014-06-05

    申请号：US14236362

    申请日：2012-08-10

    申请人： Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frasetto ,  Gemma Veitch ,  Markus Kordes ,  Marco Naujok

    发明人： Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frasetto ,  Gemma Veitch ,  Markus Kordes ,  Marco Naujok

    IPC分类号： A01N43/50 ,  A01N41/12

    CPC分类号： A01N43/56 ,  A01N37/28 ,  A01N41/12 ,  A01N43/50 ,  A01N43/80 ,  C07B2200/13 ,  C07C381/10 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

    摘要： The present invention relates to compounds of the formula (I) wherein R1 and R2 independently of one another are hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C10-cycloalkyl, C3-C10-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl or together represent an aliphatic chain, or the like; R3 is halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C8-alkenyl, C2-C8-haloalkenyl, C1-C8-alkoxy, phenyl, or the like; R4 is hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl, phenyl, or the like; t is 0 or 1; p is 0, 1, 2, 3 or 4. The present invention also relates to a process for preparing a compound of the formula (I) which comprises reacting a compound of the formula II with a compound of the formulae III or IV: where t, p, R1 R3, R3 and R4 are as defined in any of claims 1 to 6 and where A− is an equivalent of an anion having a pKB of at least 10 (determined under standard conditions in water).

    摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 2彼此独立地是氢，C 1 -C 10 - 烷基，C 1 -C 10 - 卤代烷基，C 3 -C 10 - 环烷基，C 3 -C 10 - 卤代环烷基，C 2 -C 10 烯基，C 2 -C 10 - 卤代链烯基或一起代表脂族链等; R3是卤素，氰基，C1-C8-烷基，C1-C8-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C8-烯基，C2-C8-卤代烯基，C1-C8-烷氧基，苯基， 或类似物; R4是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基，苯基等; t为0或1; 本发明还涉及制备式（I）化合物的方法，其包括使式II化合物与式III或IV化合物反应：其中 t，p，R 1，R 3，R 3和R 4如权利要求1至6中任一项所定义，其中A-是pKB为至少10（在水中标准条件下测定）的阴离子的当量。