摘要:
Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.
摘要:
Embodiments related to cryogenically ablating a portion of the inner surface of a vessel by constraining a cryoballoon using various apparatuses and methods are disclosed. For example, a catheter can include a cryoballoon for ablation of the vessel wall and a constraining element disposed substantially in parallel with the cryoballoon to deflect or offset a portion of the cryoballoon away from non-target tissue of the vessel wall and prevent ablation of the non-target tissue. Partial circumferential, non-continuous, or helical ablation can be effective for treating a variety of renal, cardio-renal, and other diseases including but not limited to hypertension, heart failure, renal disease, renal failure, contrast nephropathy, arrhythmia, and myocardial infarction. The constraining element may be, for example, a second inflatable balloon or one or more self-expanding prongs.
摘要:
Embodiments related to cryogenically ablating a vessel wall in a partial circumferential, non-continuous, or helical ablation pattern are disclosed. A catheter is disclosed that includes a cryoballoon for ablation of the vessel wall. A radially expandable insulative element is disposed over the cryoballoon to shield non-targeted tissue of the vessel wall from the cryoballoon and prevent ablation of the non-targeted tissue. Partial circumferential, non-continuous, and helical ablation can be effective for treating a variety of renal, cardio-renal, and other diseases including but not limited to hypertension, heart failure, renal disease, renal failure, contrast nephropathy, arrhythmia, and myocardial infarction. The insulative element may be, for example, a sheath component having opening(s) formed therethrough or may be an outer balloon within which the cryoballoon is disposed.
摘要:
Systems and methods related to selective heating of cryogenic balloons for targeted cryogenic neuromodulation are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having a proximal portion and a distal portion. The shaft can be configured to locate the distal portion in a vessel. The cryotherapeutic device can further include a cryoballoon extending from the distal portion and a plurality of heating elements arranged about the cryoballoon. The plurality of heating elements can be individually controlled to selectively deliver heat to tissue of a wall of the vessel proximate the outer surface of the cryoballoon.
摘要:
A connector block for retaining at least one shock tube in signal transfer relationship with a detonator. The connector block comprises a housing (2, 21) having a bore (4, 23) formed therein for receiving a detonator (6, 36) provided with a percussion-actuation end (7, 25), a shock tube retention means (8, 28) defining with the housing a slot (9, 29) for receiving therein at least one shock tube (10, 30) and holding the at least one shock tube in signal transfer relationship with the percussion-actuation end of the detonator present in the bore, the slot having an entrance (12, 32) for allowing insertion of the at least one shock tube into the slot, and a flexible and resilient closure member (11, 31) or an inflexible closure member (50) pivotable on a sprung hinge (51) extending partially or fully into the entrance. The closure member and the shock tube retention means resiliently flex to allow entry of the at least one shock tube through the entrance and into the slot, the closure member flexing through a distance at least 30% the diameter of the shock tube.
摘要:
A guide for a strand of electric lights having a plurality of light elements spaced along an electric conductor. The guide includes a tubular body having an inlet end, an outlet end, and an oblong shaped passage extending through the tubular body from the inlet end to the outlet end. The passage dimensioned to slidably receive the light elements in a way that causes the light elements to be generally oriented along a major width of the passage as the light elements pass through the tubular body.
摘要:
Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.
摘要:
Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.
摘要:
A connector block for retaining at least one shock tube in signal transfer relationship with a detonator. The connector block comprises a housing (2, 21) having a bore (4, 23) formed therein for receiving a detonator (6, 36) provided with a percussion-actuation end (7, 25), a shock tube retention means (8, 28) defining with the housing a slot (9, 29) for receiving therein at least one shock tube (10, 30) and holding the at least one shock tube in signal transfer relationship with the percussion-actuation end of the detonator present in the bore, the slot having an entrance (12, 32) for allowing insertion of the at least one shock tube into the slot, and a flexible and resilient closure member (11, 31) or an inflexible closure member (50) pivotable on a sprung hinge (51) extending partially or fully into the entrance. The closure member and the shock tube retention means resiliently flex to allow entry of the at least one shock tube through the entrance and into the slot, the closure member flexing through a distance at least 30% the diameter of the shock tube.
摘要:
Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.