公开(公告)号：US08293894B2

公开(公告)日：2012-10-23

申请号：US12312649

申请日：2007-11-20

Applicant: Andrew Gnanaprakasam ,  Nagappan Arumugam ,  Palanisamy Senthilkumar Udayampalayam ,  Pandi Suresh Pandian ,  Venugopal Sivasankaran ,  Ganapathy Veeramani ,  Henry Syril Sudhan ,  Gollapalli Venkateswara Rao

Inventor： Andrew Gnanaprakasam ,  Nagappan Arumugam ,  Palanisamy Senthilkumar Udayampalayam ,  Pandi Suresh Pandian ,  Venugopal Sivasankaran ,  Ganapathy Veeramani ,  Henry Syril Sudhan ,  Gollapalli Venkateswara Rao

IPC: C07D477/20

CPC classification number: C07D477/20 ,  Y02P20/55

Abstract: A process for the preparation of a carbapenem of formula (I): in amorphous form wherein R represents hydrogen or COOM and M represents hydrogen or sodium the process including condensing a compound of formula (II): wherein P′ denotes a carboxy protecting group, with a compound of formula (III): wherein P″ denotes a carboxy protecting group, in the presence of a base to yield a compound of formula (IV): deprotecting both the protecting groups in the compound of formula (IV) in the presence or absence of a sodium ion source, a solvent and in the presence or absence of CO2, gas, extracting the product into an aqueous medium, quenching the aqueous layer of into an alcohol at a temperature, and isolating the carbapenem compound of formula (I) in amorphous form.

Abstract translation: 制备式（I）的碳青霉烯的方法：无定形形式，其中R表示氢或COOM，M表示氢或钠，包括使式（II）化合物缩合的方法：其中P'表示羧基保护基， 与式（III）的化合物反应：其中P“表示羧基保护基，在碱存在下，得到式（IV）化合物：在存在下使式（IV）化合物中的保护基脱保护 或不存在钠离子源，溶剂，并且在存在或不存在CO 2的气体的情况下，将产物萃取到水性介质中，在一定温度下将水层猝灭为醇，并分离出式（I）的碳青霉烯化合物 ）。

公开(公告)号：US20090312539A1

公开(公告)日：2009-12-17

申请号：US12312649

申请日：2007-11-20

Applicant: Andrew Gnanaprakasam ,  Nagappan Arumugam ,  Palanisamy Senthilkumar Udayampalayam ,  Pandi Suresh Pandian ,  Venugopal Sivasankaran ,  Ganapathy Veeramani ,  Henry Syril Sudhan ,  Gollapalli Venkateswara Rao

Inventor： Andrew Gnanaprakasam ,  Nagappan Arumugam ,  Palanisamy Senthilkumar Udayampalayam ,  Pandi Suresh Pandian ,  Venugopal Sivasankaran ,  Ganapathy Veeramani ,  Henry Syril Sudhan ,  Gollapalli Venkateswara Rao

IPC: C07D487/04

CPC classification number: C07D477/20 ,  Y02P20/55

Abstract: The present invention provides a process for the preparation of the carbapenem antibiotic of formula (I) or its salt in amorphous form. Formula (I) wherein R represents hydrogen or COOM and M represents hydrogen or sodium.

Abstract translation: 本发明提供了制备式（I）的碳青霉烯类抗生素或其无定形形式的盐的方法。 式（I）其中R表示氢或COOM，M表示氢或钠。