HYDROGEL PREPARATION METHOD USING CROSSLINKING STRUCTURE CONTROL BY ELECTRON BEAM IRRADIATION AND NATURAL POLYSACCHARIDE HYDROGEL PREPARED BY THE SAME

    公开(公告)号:US20230331936A1

    公开(公告)日:2023-10-19

    申请号:US18134107

    申请日:2023-04-13

    CPC classification number: C08J3/075 C08J3/246 C08J3/28 C08J2305/00 C08J2405/00

    Abstract: Disclosed is a hydrogel preparation method using crosslinking structure control by electron beam irradiation and a hydrogel prepared by the same, and the hydrogel preparation method includes: (A) mixing two or more natural polysaccharides and a solvent at room temperature to prepare a preliminary hydrogel composition; (B) heating the preliminary hydrogel composition to a predetermined temperature or higher to cause the preliminary hydrogel composition to be loosened linearly with respect to a chain-coil structure of the natural polysaccharides, resulting in uniform mixing; (C) lowering the temperature of the preliminary hydrogel composition to room temperature to gel the preliminary hydrogel composition into a hydrogel, and allowing the two or more natural polysaccharides to form a mesh structure by chain entanglement to form an Interpenetrating Polymer Network (IPN) structure; and (D) selectively irradiating the hydrogel with a high-energy electron beam to control a crosslinking structure by using chain scission reaction in the IPN structure of the hydrogel. According to the present invention, it is possible to prepare a hydrogel composed of only two or more kinds of natural polysaccharides, and increase functionality, such as moisturizing effect, while maintaining sufficient physical strength by controlling the crosslinking structure by using a chain scission reaction through high-energy electron beam irradiation, it is possible to use excellent functionality, such as biocompatibility and biodegradability, and in particular, it is possible to adjust a mesh size to provide a natural polysaccharide hydrogel which enables the moisture or active substance entrapped in the natural polysaccharides to escape to the outside and be well delivered to the desired area.

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