公开(公告)号：US06504034B2

公开(公告)日：2003-01-07

申请号：US10043732

申请日：2002-01-10

申请人： Yi Chen ,  Apostolos Dermatakis ,  Frederick Martin Konzelmann ,  Jin-Jun Liu ,  Kin-Chun Luk

发明人： Yi Chen ,  Apostolos Dermatakis ,  Frederick Martin Konzelmann ,  Jin-Jun Liu ,  Kin-Chun Luk

IPC分类号： C07D40302

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14

摘要： Disclosed are novel naphthostyrils of formula These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing such compounds, methods for the treatment and/or prevention of cancer using such compositions, and intermediates useful in the preparation of the compounds of formula I.