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![USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE AND ALCOHOL-RELATED DISORDERS](/abs-image/US/2017/08/03/US20170216251A1/abs.jpg.150x150.jpg)
1.发明申请公开(公告)号：US20170216251A1
公开(公告)日：2017-08-03
申请号：US15257731
申请日：2016-09-06
IPC分类号： A61K31/403 , A61K45/06
CPC分类号： A61K31/403 , A61K45/06
摘要： The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing an alcohol-related or addictive disorder. The (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof is preferably substantially free of its corresponding (−)-enantiomer
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公开(公告)号：US5968926A
公开(公告)日：1999-10-19
申请号：US463615
申请日：1995-06-05
申请人： Franklin Porter Bymaster , Harlan E. Shannon , Per Sauerberg , Preben Olesen , John Stanley Ward , Charles H. Mitch
发明人： Franklin Porter Bymaster , Harlan E. Shannon , Per Sauerberg , Preben Olesen , John Stanley Ward , Charles H. Mitch
IPC分类号： A61K31/41 , A61K31/4192 , A61K31/4245 , A61K31/435 , A61K31/439 , A61P25/18 , C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08 , A61K31/46 , A61K31/44
CPC分类号： C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08
摘要： The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases.
摘要翻译： 本发明涉及一种治疗患有或易患精神分裂症和精神分裂症样疾病的哺乳动物的新方法。
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![USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE AND ALCOHOL-RELATED DISORDERS](/abs-image/US/2018/10/18/US20180296527A1/abs.jpg.150x150.jpg)
3.发明申请公开(公告)号：US20180296527A1
公开(公告)日：2018-10-18
申请号：US15813703
申请日：2017-11-15
IPC分类号： A61K31/403 , A61K45/06
摘要： The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing an alcohol-related or addictive disorder. The (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof is preferably substantially free of its corresponding (−)-enantiomer
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![USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE AND ALCOHOL-RELATED DISORDERS](/abs-image/US/2014/10/23/US20140315892A1/abs.jpg.150x150.jpg)
4.发明申请USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE AND ALCOHOL-RELATED DISORDERS 审中-公开（+） - 1-（3,4-二氯苯基）-3-亚甲基[[3.1.0] HEXANE用于治疗残疾和酒精相关疾病的用途公开(公告)号：US20140315892A1
公开(公告)日：2014-10-23
申请号：US14170290
申请日：2014-01-31
IPC分类号： A61K31/403 , A61K45/06
CPC分类号： A61K31/403 , A61K45/06
摘要： The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing an alcohol-related or addictive disorder. The (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof is preferably substantially free of its corresponding (+)-enantiomer
摘要翻译： 本发明涉及（+） - 1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷及其药学上可接受的盐，其包含（+） - 1-（3,4-二氯苯基） 3-氮杂二环[3.1.0]己烷或其药学上可接受的盐，以及用于治疗或预防酒精相关或成瘾性疾病的方法。 （+） - 1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或其药学上可接受的盐优选基本上不含相应的（+） - 对映体
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![USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE AND ALCOHOL-RELATED DISORDERS](/abs-image/US/2021/02/18/US20210046044A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210046044A1
公开(公告)日：2021-02-18
申请号：US16865903
申请日：2020-05-04
IPC分类号： A61K31/403 , A61K45/06
摘要： The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing an alcohol-related or addictive disorder. The (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof is preferably substantially free of its corresponding (−)-enantiomer
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公开(公告)号：US5980933A
公开(公告)日：1999-11-09
申请号：US942141
申请日：1997-09-29
申请人： Franklin Porter Bymaster , Michael Horstmann , Harlan E. Shannon , Lisa A. Shipley , Kirti H. Valia
发明人： Franklin Porter Bymaster , Michael Horstmann , Harlan E. Shannon , Lisa A. Shipley , Kirti H. Valia
CPC分类号： A61K9/7061 , A61K31/4439 , A61K9/7084
摘要： The present invention provides a method for treating Alzheimer's Disease using a xanomeline transdermal formulation. The invention provides desired transdermal xanomeline patch formulations.
摘要翻译： 本发明提供了使用xanomeline透皮制剂治疗阿尔茨海默病的方法。 本发明提供所需的透皮皮肤贴剂制剂。
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公开(公告)号：US5679686A
公开(公告)日：1997-10-21
申请号：US465215
申请日：1995-06-05
申请人： Franklin Porter Bymaster , Harlan E. Shannon , Per Sauerberg , Preben H. Olesen , John Stanley Ward , Charles H. Mitch
发明人： Franklin Porter Bymaster , Harlan E. Shannon , Per Sauerberg , Preben H. Olesen , John Stanley Ward , Charles H. Mitch
IPC分类号： A61K31/41 , A61K31/4192 , A61K31/4245 , A61K31/435 , A61K31/439 , A61P25/18 , C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08 , A61K31/46 , A61K31/44
CPC分类号： C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08
摘要： The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases.
摘要翻译： 本发明涉及用于治疗患有或易患精神分裂症和精神分裂症样疾病的哺乳动物的新方法。
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公开(公告)号：US5677313A
公开(公告)日：1997-10-14
申请号：US462931
申请日：1995-06-05
申请人： Franklin Porter Bymaster , Harlan E. Shannon , Per Sauerberg , Preben H. Olesen , John Stanley Ward , Charles H. Mitch
发明人： Franklin Porter Bymaster , Harlan E. Shannon , Per Sauerberg , Preben H. Olesen , John Stanley Ward , Charles H. Mitch
IPC分类号： A61K31/41 , A61K31/4192 , A61K31/4245 , A61K31/435 , A61K31/439 , A61P25/18 , C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08 , A61K31/46 , A61K31/44
CPC分类号： C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08
摘要： The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases.
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公开(公告)号：US5663182A
公开(公告)日：1997-09-02
申请号：US633685
申请日：1996-04-17
申请人： Franklin Porter Bymaster , Harlan E. Shannon , Per Sauerberg , Preben H. Olesen , John Stanley Ward , Charles H. Mitch
发明人： Franklin Porter Bymaster , Harlan E. Shannon , Per Sauerberg , Preben H. Olesen , John Stanley Ward , Charles H. Mitch
IPC分类号： C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08 , A16K31/44
CPC分类号： C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08
摘要： The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases.
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公开(公告)号：US5858393A
公开(公告)日：1999-01-12
申请号：US918141
申请日：1997-08-25
IPC分类号： A61K9/70 , A61K31/435 , A61K31/439 , A61K47/06 , A61P25/04 , A61P25/28 , A61F13/02
CPC分类号： A61K9/7061 , A61K31/439 , A61K9/7084
摘要： The present invention provides a method for treating a condition associated with muscarinic receptor modulation using a 3-�4-(butylthio)-1,2,5-thiadiazol-3-yl!-1-azabicyclo-�2.2.2!octane transdermal formulation. The invention provides desired transdermal 3-�4-(butylthio)-1,2,5-thiadiazol-3-yl!-1-azabicyclo�2.2.2!octane patch formulations.
摘要翻译： 本发明提供了使用3- [4-（丁硫基）-1,2,5-噻二唑-3-基] -1-氮杂双环[2.2.2]辛烷经皮处理与毒蕈碱受体调节有关的病症的方法 公式。 本发明提供所需的透皮3- [4-（丁硫基）-1,2,5-噻二唑-3-基] -1-氮杂双环[2.2.2]辛烷贴片制剂。
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