公开(公告)号：US20250052739A1

公开(公告)日：2025-02-13

申请号：US18717767

申请日：2022-12-05

Applicant: Firmenich Incorporated

Inventor： Guy Servant ,  Mark E. Williams ,  Joseph R. Fotsing ,  Lan Zhang

IPC: G01N33/50 ,  G01N33/566

Abstract: The present disclosure generally provides methods for identifying compounds that attenuate the bitter taste of plant proteins. In some particular aspects, the disclosure provides methods of identifying compounds that attenuate the bitter taste of plant proteins by determining whether the compounds modulate certain T2R bitter taste receptors. In some other aspects, the disclosure provides uses of such identified compounds to attenuate the bitter taste of an ingestible composition that comprises one or more plant proteins. In some further aspects, the disclosure provides flavored products, such as food or beverage products, that incorporate such ingestible compositions. Such food products include meat and dairy analogues.

公开(公告)号：US20240225066A1

公开(公告)日：2024-07-11

申请号：US18563462

申请日：2022-06-23

Applicant: Firmenich Incorporated

Inventor： Chris Edano NORIEGA ,  Rama Rao MANAM ,  Mark WILLIAMS ,  Tanya DITSCHUN

IPC: A23L27/30 ,  A23L27/00 ,  C07J17/00

CPC classification number: A23L27/36 ,  A23L27/88 ,  C07J17/005

Abstract: The present disclosure generally relates to certain mogroside compounds and the use of such compounds as sweeteners or to enhance sweetness when used in combination with other sweeteners. In certain aspects, the disclosure provides ingestible compositions and that include such mogroside compounds. In some embodiments, such ingestible compositions comprise monk fruit juice, monk fruit extract, or a combination thereof. In some related aspects, the ingestible compositions are, or are included within, various flavored products, such as food products, beverage products, or oral care products.

公开(公告)号：US20240114942A1

公开(公告)日：2024-04-11

申请号：US18506526

申请日：2023-11-10

Applicant: Firmenich Incorporated

Inventor： Joseph R. Fotsing ,  Andrew Patron ,  Guy Servant ,  Lan Zhang ,  Mark Williams ,  Qing Chen ,  Kenneth Simone ,  Vincent Darmohusodo ,  Chad Priest ,  Melissa S. Wong ,  Thomas Brady

IPC: A23L27/00 ,  C07D317/66 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: A23L27/86 ,  C07D317/66 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.

公开(公告)号：US20240108040A1

公开(公告)日：2024-04-04

申请号：US18363597

申请日：2023-08-01

Applicant: Firmenich Incorporated

Inventor： Andrew Patron ,  Rama Manam ,  Justin Colquitt ,  Nicole Servant ,  Chris Edano Noriega ,  Jeffrey R. Hammaker ,  Nicole Gonsalves ,  Tanya Ditschun

IPC: A23L27/20 ,  A23L2/385 ,  A23L2/52 ,  A23L2/60 ,  A23L27/00 ,  A23L27/30 ,  A23P10/20 ,  C07J9/00 ,  C07J17/00

CPC classification number: A23L27/204 ,  A23L2/385 ,  A23L2/52 ,  A23L2/60 ,  A23L27/00 ,  A23L27/36 ,  A23P10/20 ,  C07J9/00 ,  C07J17/005 ,  A23V2002/00

Abstract: Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods of increasing the sweet taste of ingestible compositions. Furthermore, methods for preparing the compounds are also disclosed.

公开(公告)号：US20240065302A1

公开(公告)日：2024-02-29

申请号：US18271414

申请日：2022-01-13

Applicant: Firmenich Incorporated

Inventor： Rama Manam ,  Tanya Ditschun ,  Dattatreya Banavara ,  Priti Jha ,  Imad Farhat

IPC: A23L27/30 ,  A23C9/156 ,  A23L2/54 ,  A23L2/60 ,  A23L27/00

CPC classification number: A23L27/36 ,  A23C9/156 ,  A23L2/54 ,  A23L2/60 ,  A23L27/86 ,  A23L27/88

Abstract: Formulations comprising siratose are provided herein, wherein the formulation is provided for use in ingestible products, such as food or beverage products or pharmaceutical, or for use in non-comestible products, such as cosmetic or hygienic products.

公开(公告)号：US20220236254A1

公开(公告)日：2022-07-28

申请号：US17630757

申请日：2020-09-04

Applicant: Firmenich Incorporated

Inventor： Guy Servant ,  Mark Williams ,  Lan Zhang

IPC: G01N33/50 ,  G01N33/566 ,  G01N33/68

Abstract: The present disclosure generally provides methods for identifying compounds that block bitter receptors, particularly the bitter receptors activated by certain compounds commonly present in Citrus extracts. The disclosure also provides compositions comprising such compounds and methods of their use.

公开(公告)号：US11339128B2

公开(公告)日：2022-05-24

申请号：US14925793

申请日：2015-10-28

Applicant: Firmenich Incorporated

Inventor： Goran Petrovic ,  Joseph R. Fotsing ,  Guy Servant ,  Catherine Tachdjian ,  Donald Karanewsky ,  Binh Vong ,  Brant Clayton Boren ,  Qing Chen ,  Hong Zhang ,  Brett Weylan Ching ,  Stephanie Lapera

IPC: C07D215/54 ,  C07D401/12 ,  C07D405/12 ,  A23L27/20 ,  A23L27/00 ,  A23L2/56 ,  A23L2/60

Abstract: Disclosed herein are 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acid compounds having useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener.

公开(公告)号：US20210324439A1

公开(公告)日：2021-10-21

申请号：US17355912

申请日：2021-06-23

Applicant: Firmenich Incorporated

Inventor： Andrew P. Patron ,  Chris Edano Noriega ,  Rama R. Manam ,  Justin Colquitt ,  Nathan Faber ,  Helge Zieler ,  Justin Stege

IPC: C12P33/00 ,  C12P33/12 ,  A23L27/30 ,  C07J17/00 ,  C12N9/02 ,  C12N9/42 ,  C12N9/90 ,  C12P33/20

Abstract: Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions (for example, cell lysates) and recombinant cells comprising the mogroside compounds (e.g., Compound 1). Also provided herein are novel cucurbitadienol synthases and the use thereof.

公开(公告)号：US11129397B2

公开(公告)日：2021-09-28

申请号：US16352430

申请日：2019-03-13

Applicant: Firmenich Incorporated

Inventor： Catherine Tachdjian ,  Donald Karanewsky ,  Xiao Qing Tang ,  Hanghui Liu

IPC: A23L2/56 ,  A23L27/00 ,  A23L27/20 ,  A61K47/26 ,  A61K47/22

Abstract: The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

公开(公告)号：US11060124B2

公开(公告)日：2021-07-13

申请号：US15969616

申请日：2018-05-02

Applicant: Firmenich Incorporated

Inventor： Andrew P. Patron ,  Chris Edano Noriega ,  Rama R. Manam ,  Justin Colquitt ,  Nathan Faber ,  Helge Zieler ,  Justin Stege

IPC: C12P33/00 ,  C12P33/20 ,  C12N9/02 ,  C12N9/90 ,  C12P33/12 ,  A23L27/30 ,  C07J17/00 ,  C12N9/42 ,  C12P19/18 ,  C12P19/56

Abstract: Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions (for example, cell lysates) and recombinant cells comprising the mogroside compounds (e.g., Compound 1). Also provided herein are novel cucurbitadienol synthases and the use thereof.