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公开(公告)号：US20100266599A1
公开(公告)日：2010-10-21
申请号：US12715848
申请日：2010-03-02
申请人： GERARD T. HARDIMAN , FERNANDO L. ROCK , J. FERNANDO BAZAN , ROBERT A. KASTELEIN , STEPHEN W.K. HO , YONG-JUN LIU
发明人： GERARD T. HARDIMAN , FERNANDO L. ROCK , J. FERNANDO BAZAN , ROBERT A. KASTELEIN , STEPHEN W.K. HO , YONG-JUN LIU
IPC分类号： A61K39/395 , C07K14/00 , C07H21/00 , C12N15/63 , C07K16/00 , A61P31/00 , A61P31/12 , A61P35/02 , A61P35/00 , A61P37/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
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公开(公告)号：US07271248B2
公开(公告)日：2007-09-18
申请号：US10975909
申请日：2004-10-28
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W. K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W. K. Ho , Yong-Jun Liu
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
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公开(公告)号：US06225446B1
公开(公告)日：2001-05-01
申请号：US08759628
申请日：1996-12-05
IPC分类号： C07K1452
CPC分类号： C07K14/5759 , A61K38/00
摘要： Muteins, which are mutational variants of mammalian proteins. Particular positions of natural proteins are identified as critical in providing various different activities. Specific embodiments demonstrate properties of variations at these positions.
摘要翻译： 突变蛋白是突变型哺乳动物蛋白质。 天然蛋白质的特殊位置被认为是提供各种不同活性的关键。 具体实施方式示出了在这些位置处的变化的性质。
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公开(公告)号：US20080199477A1
公开(公告)日：2008-08-21
申请号：US12100088
申请日：2008-04-09
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
IPC分类号： A61K39/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
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公开(公告)号：US20080194800A1
公开(公告)日：2008-08-14
申请号：US12100108
申请日：2008-04-09
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
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6.发明授权公开(公告)号：US07670603B2
公开(公告)日：2010-03-02
申请号：US12100088
申请日：2008-04-09
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W. K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W. K. Ho , Yong-Jun Liu
IPC分类号： A61K39/395 , C12N15/09 , C12P21/06 , C07K14/47
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
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