公开(公告)号：US20110165086A1

公开(公告)日：2011-07-07

申请号：US12981389

申请日：2010-12-29

申请人： Chulhyun Lee ,  Sung Lan Jeon ,  Min Kyung Chae ,  Jee-Hyun Cho ,  Eun Ju Jang

发明人： Chulhyun Lee ,  Sung Lan Jeon ,  Min Kyung Chae ,  Jee-Hyun Cho ,  Eun Ju Jang

IPC分类号： A61B5/055 ,  A61K9/50 ,  B05D3/10 ,  C01G49/02 ,  B82Y5/00

CPC分类号： A61B5/055 ,  A61K9/51 ,  A61K9/5115 ,  A61K49/1836 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C01G49/04 ,  C01G49/08 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/34 ,  C01P2004/64 ,  C09C1/24 ,  Y10S977/773 ,  Y10S977/788 ,  Y10S977/81 ,  Y10S977/906 ,  Y10S977/93

摘要： Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron oxide nano contrast agents can be prepared by the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe3O4 nanoparticles having an interior space.

摘要翻译： 公开了具有优异T2对比效果的磁共振成像用氧化铁纳米造影剂，也可用作药物的储存或载体等。 氧化铁纳米造影剂可以通过以下步骤制备：用有机溶剂中的选自聚乙二醇 - 磷脂缀合物，葡聚糖，壳聚糖，二巯基琥珀酸及其混合物的涂层材料涂覆疏水性FeO纳米颗粒的表面， 形成具有亲水表面和在水中分散性的亲水性FeO纳米颗粒; 将亲水性FeO纳米颗粒分散在水中以氧化FeO; 并将氧化的亲水性FeO纳米颗粒暴露于酸性缓冲液以溶解和除去内部未氧化的FeO部分，从而形成具有内部空间的Fe 3 O 4纳米颗粒。

公开(公告)号：US20220087470A1

公开(公告)日：2022-03-24

申请号：US17425557

申请日：2019-05-21

申请人： Sang Hyuk HAN ,  Eun Ju JANG

发明人： Sang Hyuk HAN ,  Eun Ju JANG

IPC分类号： A47J36/02 ,  A47J27/00

摘要： Provided is a cooking utensil for cooking by variously combining multi-structured composite bases according to a user's selection. The cooking utensil includes: a base portion made of a composite material and formed to have different thermal conductivities of a heat source according to cooking ingredients and cooking methods; a body portion into which the cooking ingredients are put and to which the base portion is detachably coupled; and a lid configured to seal an upper part of the body portion.

公开(公告)号：US08524195B2

公开(公告)日：2013-09-03

申请号：US12981389

申请日：2010-12-29

申请人： Chulhyun Lee ,  Sung Lan Jeon ,  Min Kyung Chae ,  Jee-Hyun Cho ,  Eun Ju Jang

发明人： Chulhyun Lee ,  Sung Lan Jeon ,  Min Kyung Chae ,  Jee-Hyun Cho ,  Eun Ju Jang

IPC分类号： A61B5/055 ,  A61K51/00

CPC分类号： A61B5/055 ,  A61K9/51 ,  A61K9/5115 ,  A61K49/1836 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C01G49/04 ,  C01G49/08 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/34 ,  C01P2004/64 ,  C09C1/24 ,  Y10S977/773 ,  Y10S977/788 ,  Y10S977/81 ,  Y10S977/906 ,  Y10S977/93

摘要： Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron oxide nano contrast agents can be prepared by the steps of: coating surfaces of hydrophobic FeO nanoparticles with a coating material selected from the group consisting of polyethylene glycol-phospholipid conjugate, dextran, chitosan, dimercaptosuccinic acid and mixtures thereof in an organic solvent to form hydrophilic FeO nanoparticles having hydrophilic surfaces and dispersibility in water; dispersing the hydrophilic FeO nanoparticles in water to oxidize FeO; and exposing the oxidized hydrophilic FeO nanoparticles to an acidic buffer to dissolve and remove interior unoxidized FeO portions, and thereby to form Fe3O4 nanoparticles having an interior space.

摘要翻译： 公开了具有优异T2对比效果的磁共振成像用氧化铁纳米造影剂，也可用作药物的储存或载体等。 氧化铁纳米对比剂可以通过以下步骤制备：用有机溶剂中的选自聚乙二醇 - 磷脂缀合物，葡聚糖，壳聚糖，二巯基琥珀酸及其混合物的涂层材料涂覆疏水性FeO纳米颗粒的表面， 形成具有亲水表面和在水中分散性的亲水性FeO纳米颗粒; 将亲水性FeO纳米颗粒分散在水中以氧化FeO; 并将氧化的亲水性FeO纳米颗粒暴露于酸性缓冲液以溶解和除去内部未氧化的FeO部分，从而形成具有内部空间的Fe 3 O 4纳米颗粒。