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1.发明授权Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US08357684B2
公开(公告)日：2013-01-22
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Eugene Y. Cheung , Christa C. Chrovian , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener
发明人： Genesis M. Bacani , Eugene Y. Cheung , Christa C. Chrovian , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/506 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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2.发明申请Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20110159563A1
公开(公告)日：2011-06-30
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： C12N9/99 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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公开(公告)号：US07939527B2
公开(公告)日：2011-05-10
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/516 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
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4.发明申请Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 审中-公开噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20110190503A1
公开(公告)日：2011-08-04
申请号：US13039105
申请日：2011-03-02
申请人： Genesis M. BACANI , Diego BROGGINI , Eugene Y. CHEUNG , Christa C. CHROVIAN , Xiaohu DENG , Anne M. FOURIE , Laurent GOMEZ , Cheryl A. GRICE , Aaron M. KEARNEY , Adrienne M. LANDRY-BAYLE , Alice LEE-DUTRA , Jimmy T. LIANG , Susanne LOCHNER , Neelakandha S. MANI , Alejandro SANTILLÁN, JR. , Kathleen SAPPEY , Kia SEPASSI , Virginia M. TANIS , Alvah T. WICKBOLDT , John J. M. WIENER , Hartmut ZINSER
发明人： Genesis M. BACANI , Diego BROGGINI , Eugene Y. CHEUNG , Christa C. CHROVIAN , Xiaohu DENG , Anne M. FOURIE , Laurent GOMEZ , Cheryl A. GRICE , Aaron M. KEARNEY , Adrienne M. LANDRY-BAYLE , Alice LEE-DUTRA , Jimmy T. LIANG , Susanne LOCHNER , Neelakandha S. MANI , Alejandro SANTILLÁN, JR. , Kathleen SAPPEY , Kia SEPASSI , Virginia M. TANIS , Alvah T. WICKBOLDT , John J. M. WIENER , Hartmut ZINSER
IPC分类号： C07D451/02
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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5.发明申请Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20090258854A1
公开(公告)日：2009-10-15
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/437 , C07D513/04 , A61K31/506 , A61K31/5377 , A61K31/4985 , A61P29/00 , C12N9/50 , C07D453/02
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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