公开(公告)号：US5015736A

公开(公告)日：1991-05-14

申请号：US437414

申请日：1989-11-15

申请人： Juan Cabre Castellvi ,  Jose Diago Meseguer ,  Asuncion Esteve Bianchini ,  Carlos E. Lenhardt Padro ,  Esteve Sans Pitarch

发明人： Juan Cabre Castellvi ,  Jose Diago Meseguer ,  Asuncion Esteve Bianchini ,  Carlos E. Lenhardt Padro ,  Esteve Sans Pitarch

IPC分类号： C07D241/08 ,  C07D499/00 ,  C07D499/68 ,  C07D501/20 ,  C07D501/36

CPC分类号： C07D499/00 ,  C07D241/08

摘要： A new compound called N,N'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine of Formula I ##STR1## A process for the preparation thereof based on the reaction of 4-ethyl-2,3-dioxo-piperazine or a trimethylsilyl derivative thereof with carbonyl chloride or a derivative thereof.The use of the compound of Formula I as an intermediate in the preparation of compounds of Formula II ##STR2## where R is a radical, substituted in alpha position, of a molecule of an acid selected from the group formed by phenylacetic acid, p-hydroxy phenylacetic acid, a 6-(phenylacetamido)-penicillanic acid and a 7-(phenylacetamido)-cephalosporanic acid.

公开(公告)号：US4965358A

公开(公告)日：1990-10-23

申请号：US269916

申请日：1988-11-10

申请人： Juan Cabre Castellvi ,  Jose Diago Meseguer ,  Asuncion Esteve Bianchini ,  Carlos E. Lenhardt Padro ,  Esteve Sans Pitarch

发明人： Juan Cabre Castellvi ,  Jose Diago Meseguer ,  Asuncion Esteve Bianchini ,  Carlos E. Lenhardt Padro ,  Esteve Sans Pitarch

IPC分类号： C07D241/08 ,  C07D499/00 ,  C07D499/68 ,  C07D501/20 ,  C07D501/36

CPC分类号： C07D499/00 ,  C07D241/08

摘要： A new compound called N,N'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine of Formula I ##STR1## A process for the preparation thereof based on the reaction of 4-ethyl-2,3-dioxo-piperazine or a trimethylsilyl derivative thereof with carbonyl chloride or a derivative thereof.The use of the compound of Formula I as an intermediate in the preparation of compounds of Formula II ##STR2## where R is a radical, substituted in alpha position, of a molecule of an acid selected from the group formed by phenylacetic acid, p-hydroxy phenylacetic acid, a 6-(phenylacetamido)-penicillanic acid and a 7-(phenylacetamido)-cephalosporanic acid.

公开(公告)号：US5037988A

公开(公告)日：1991-08-06

申请号：US367656

申请日：1989-06-19

申请人： Jose Diago Meseguer ,  Asuncion Esteve Bianchini ,  Carlos E. Lenhardt Padro ,  Esteve Sans Pitarch

发明人： Jose Diago Meseguer ,  Asuncion Esteve Bianchini ,  Carlos E. Lenhardt Padro ,  Esteve Sans Pitarch

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/40 ,  C07D277/587 ,  C07D501/06 ,  C07D501/20 ,  C07D501/22 ,  C07D501/32 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56

CPC分类号： C07D277/587

摘要： The invention relates to activated aminothiazolyl-oximinoacetic acid derivatives, their production and their use in the production of e.g. amides, in particular cephalosporin antibiotics.