公开(公告)号：US20090105461A1

公开(公告)日：2009-04-23

申请号：US12221551

申请日：2008-08-04

申请人： Arthur Kunz ,  Justin Keith Moran ,  Joseph Thomas Rubino ,  Neera Jain ,  Erwin Raymond Arsene Boghaert ,  Philip Ross Hamann ,  Mark Edward Ruppen ,  Nitin Krishnaji Damle ,  Eugene Vidunas ,  Lyka Kalyandrug

发明人： Arthur Kunz ,  Justin Keith Moran ,  Joseph Thomas Rubino ,  Neera Jain ,  Erwin Raymond Arsene Boghaert ,  Philip Ross Hamann ,  Mark Edward Ruppen ,  Nitin Krishnaji Damle ,  Eugene Vidunas ,  Lyka Kalyandrug

IPC分类号： C07K16/00

CPC分类号： C07K16/30 ,  A61K39/395 ,  A61K47/6829 ,  A61K47/6849 ,  A61K47/6851 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/73

摘要： Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

摘要翻译： 描述了抗Lewis Y抗体。 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。 具体地，还描述了单体加利车霉素衍生物/抗 - 路易斯Y抗体缀合物，包含缀合物的组合物和缀合物的用途。