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公开(公告)号：US20070293573A1
公开(公告)日：2007-12-20
申请号：US11678396
申请日：2007-02-23
申请人： ERIC GOUAUX , Langzhou SONG , Yuli XIE , Donald LANDRY
发明人： ERIC GOUAUX , Langzhou SONG , Yuli XIE , Donald LANDRY
IPC分类号： A61K31/195 , A61K31/10 , A61P25/24 , C07C233/00 , C07C317/00 , C07C311/00 , C07C229/00 , A61K31/145
CPC分类号： C07C311/03
摘要： The present invention provides for compositions and methods for modulating the GluR2 receptor. It is based, at least in part, on the discovery, by X-ray crystallography, that a known GluR2 agonist binds to the receptor in two different orientations, thereby diminishing its potency. The present invention provides for structural alternatives in which alternative binding possibilities are substantially eliminated.
摘要翻译： 本发明提供了用于调节GluR2受体的组合物和方法。 至少部分地基于X射线晶体学发现，已知的GluR2激动剂以两种不同取向与受体结合，从而降低其效力。 本发明提供了其中基本上消除了替代结合可能性的结构替代方案。
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公开(公告)号：US20090270508A1
公开(公告)日：2009-10-29
申请号：US12322274
申请日：2009-01-30
申请人： James Eric Gouaux , Langzhou Song , Yuli Xie , Donald W. Landry
发明人： James Eric Gouaux , Langzhou Song , Yuli Xie , Donald W. Landry
IPC分类号： A61K31/18 , C07C311/01 , A61P25/24
CPC分类号： C07C311/03
摘要： The present invention provides for compositions and methods for modulating the GluR2 receptor. It is based, at least in part, on the discovery, by X-ray crystallography, that a known GluR2 agonist binds to the receptor in two different orientations, thereby diminishing its potency. The present invention provides for structural alternatives in which alternative binding possibilities are substantially eliminated.
摘要翻译： 本发明提供了用于调节GluR2受体的组合物和方法。 至少部分地基于X射线晶体学发现，已知的GluR2激动剂以两种不同取向与受体结合，从而降低其效力。 本发明提供了其中基本上消除了替代结合可能性的结构替代方案。
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公开(公告)号：US06824659B2
公开(公告)日：2004-11-30
申请号：US09784985
申请日：2001-02-15
申请人： Hagan Bayley , Orit Braha , John Kasianowicz , Eric Gouaux
发明人： Hagan Bayley , Orit Braha , John Kasianowicz , Eric Gouaux
IPC分类号： G01N27327
CPC分类号： C07K14/31 , G01N33/48721
摘要： A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
摘要翻译： 在野生型葡萄球菌α溶血素多肽，数字生物传感器以及检测，鉴定和定量分析物的方法中，含有异源分析物结合氨基酸的突变型葡萄球菌α溶血素多肽组装成分析物响应性七聚体孔组件， 描述。
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4.发明申请公开(公告)号：US20090104645A1
公开(公告)日：2009-04-23
申请号：US12187911
申请日：2008-08-07
IPC分类号： C12Q1/02
CPC分类号： G01N33/6809
摘要： The present invention provides for methods, systems and materials that may be used to identify and select proteins that are amenable to crystallization. While previous methods of screening proteins for crystallization required at least microgram quantities of purified protein, the inventive method can be practiced using nanogram quantities of unpurified protein.
摘要翻译： 本发明提供可用于鉴定和选择适于结晶的蛋白质的方法，系统和材料。 虽然筛选蛋白质用于结晶的先前方法需要至少微克量的纯化蛋白质，但本发明的方法可以使用纳克数量的未纯化蛋白质来实施。
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公开(公告)号：US20050131211A1
公开(公告)日：2005-06-16
申请号：US10946802
申请日：2004-09-21
申请人： Hagan Bayley , Orit Braha , John Kasianowicz , Eric Gouaux
发明人： Hagan Bayley , Orit Braha , John Kasianowicz , Eric Gouaux
CPC分类号： C07K14/31 , G01N33/48721
摘要： A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
摘要翻译： 在野生型葡萄球菌α溶血素多肽，数字生物传感器以及检测，鉴定和定量分析物的方法中，含有异源分析物结合氨基酸的突变体葡萄球菌α溶血素多肽组装成分析物响应性七聚体孔组件， 描述。
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